Isolated Left Ventricular Noncompaction: Unusual Cause of Decompensated Heart Failure and Indication of Heart Transplantation in the Early Infancy - Case Report and Literature Review

Barbosa, Natasha Damásio Fairbanks; Azeka, Estela; Aiello, Vera Demarchi; Viana, Fernanda; Jatene, Marcelo Biscegli; Tanamati, Carla; Marcial, Miguel Barbero

doi:10.1590/s1807-59322008000100022

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…Histological examination shows that trabeculations are built up of myocardiocytes, vessels, axons, and fibrocytes and are all lined with endocardium to form the layered sponge-like convolute attached to the inner apical LV myocardium (Fig. 4) [47]. Though nuclei of cardiomyocytes are irregular and abnormal, arrangement and appearance of muscle bundles is normal, and cell nuclei are evenly distributed within the trabeculations [45].…”

Section: Explanted Hearts and Autopsymentioning

confidence: 99%

“…The most widely discussed speculation explains LVHT by a disturbed embryonic involutionary compaction process, which starts by day 35 and is usually completed by day 70 of gestation [24,47]. Trabeculations in the embryonic heart are first evident by the end of the fourth gestational week.…”

Section: Congenital Lvhtmentioning

confidence: 99%

“…Predictors of mortality in adults are advanced [121] and heart failure [122]. The commonest cause of death in most of the studies is intractable heart failure or sudden cardiac death [47]. At the moment, there is a general agreement that the outcome of LVHT is quite variable, depending on cardiac and neurologic comorbidities [123].…”

Section: Outcome and Prognostic Stratificationmentioning

confidence: 99%

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Left ventricular non-compaction and its cardiac and neurologic implications

Finsterer

2010

Heart Fail Rev

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Left ventricular non-compaction, also known as left ventricular hypertrabeculation (LVHT), is a morphological abnormality of the left ventricular myocardium, characterised by a meshwork of myocardial strings, interlacing, and orderless in arrangement. LVHT is most frequently located in the apex and the lateral wall and may occur with or without other congenital or acquired cardiac abnormalities. LVHT is believed to be congenital in the majority of the cases but may develop during life in single cases (acquired LVHT). Congenital LVHT is believed to result from defective late-stage embryonic development of the myocardial architecture. The pathogenesis of acquired LVHT remains speculative. LVHT is most frequently found on transthoracic echocardiography and cardiac MRI but may be visualised also with other imaging techniques. In the majority of the cases, LVHT is associated with hereditary cardiac, neuromuscular, non-cardiac/non-muscle disease, or chromosomal aberrations. In the majority of the cases, LVHT is complicated by ventricular arrhythmias, systolic dysfunction, cardiac embolism, or sudden cardiac death. LVHT per se does not require a specific treatment. Only in case of complications, such as ventricular arrhythmias, cardioembolism, or systolic dysfunction, adequate therapy is indicated. Though initially assessed as poor, the prognosis of LVHT has meanwhile improved, most likely due to the increased awareness for the abnormality and the timely administration of adequate therapy.

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Section: Explanted Hearts and Autopsymentioning

confidence: 99%

Section: Congenital Lvhtmentioning

confidence: 99%

Section: Outcome and Prognostic Stratificationmentioning

confidence: 99%

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Left ventricular non-compaction and its cardiac and neurologic implications

Finsterer

2010

Heart Fail Rev

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“…[1] It is thought to be the result of an arrest in the normal endomyocardial embryogenesis, which leads to the persistence of intertrabecular recesses and the development of a spongy myocardium. The World Health Organization has categorised it as an unclassified cardiomyopathy.…”

Section: Case Reportmentioning

confidence: 99%

Isolated non-compaction of the left ventricle

Kshirsagar¹,

Ahmed²,

Colaco³

et al. 2014

S Afr J CH

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“…The discussion on the importance of physical activity in patients with FCII, with impact on the quality of life, functional classes and characteristic features of respiratory variables and heart rate, even in patients undergoing treatment with beta-blockers, have represented advances in this area [14][15][16][17] . The criteria for diagnostic confirmation of myocardial noncompaction, as well as therapeutic strategies in this newly discovered novel classification of cardiomyopathies have also aroused the interest of researchers [18][19][20] . Other forms of clinical presentation and the etiology of cardiomyopathies have also been studied.…”

Section: Introductionmentioning

confidence: 99%

Impacto das publicações científicas brasileiras nos recentes avanços científicos na cardiologia

Bacal¹

2009

Arq. Bras. Cardiol.

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The Brazilian research, in the clinical and surgical areas as well as in the basic areas, has developed greatly in recent years. Cardiology, in turn, has effectively contributed for this development. Currently, the Brazilian Archives of Cardiology (Arquivos Brasileiros de Cardiologia), an ISI-indexed journal, joins other important national and also indexed journals, offering the national and international researchers good options for the publication of their studies. This Editorial will discuss the impact of the recent Brazilian scientific publications from the clinical and surgical areas in Cardiology.

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Isolated Left Ventricular Noncompaction: Unusual Cause of Decompensated Heart Failure and Indication of Heart Transplantation in the Early Infancy - Case Report and Literature Review

Cited by 11 publications

References 25 publications

Left ventricular non-compaction and its cardiac and neurologic implications

Left ventricular non-compaction and its cardiac and neurologic implications

Isolated non-compaction of the left ventricle

Impacto das publicações científicas brasileiras nos recentes avanços científicos na cardiologia

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