Obesity, Inflammation, Vascular Reactivity, and Cardiocirculatory Events

Faintuch, Joel; Horie, L.M.; Schmidt, Vanessa; Barbeiro, Hermes Vieira; Barbeiro, Denise Frediani; Soriano, Francisco; Cecconello, Ivan

doi:10.1590/s1807-59322007000300023

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Obesity is a chronic disease characterized by excessive body fat that causes damage to the individual’s health 1 , 2 and is associated with comorbidities such as diabetes 3 and hypertension. 3 , 4 and vascular dysfunction 5 , 6 Obesity in adults is defined by the World Health Organization (WHO) as having a body mass index (BMI) that is greater than or equal to 30 kg/m 2.2 The normal BMI range is between 18.5 and 24.99 kg/m. 24 …”

Section: Introductionmentioning

confidence: 99%

The Impact of Obesity on Pulmonary Function in Adult Women

Costa

Barbalho

Miguel

et al. 2008

Clinics

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INTRODUCTION:Obesity can cause deleterious effects on respiratory function and impair health and quality of life. OBJECTIVE: To evaluate the effects of obesity on the pulmonary function of adult women. METHODS: An obese group, constituted of 20 women between 20 and 35 years old with a BMI of 35 -49.99 kg/m 2 who were non-smokers and sedentary and had no lung disease were recruited. The non-obese group consisted of 20 women between 20 and 35 years old who were sedentary and non-smokers and had no lung disease and a body mass index between 18.5 and 24.99 kg/m 2 . Spirometry was performed in all subjects. The statistical analysis consisted of parametric or non-parametric tests, depending on the distribution of each variable, considering p < 0.05 to be statistically significant. RESULTS:The obese group presented a mean age of 25.85 ± 3.89 years and a mean BMI of 41.1 ± 3.46 kg/m 2 , and the non-obese group presented a mean age of 23.9 ± 2.97 years and a mean body mass index of 21.91 ± 1.81 kg/m 2 . There were no significant differences between the obese group and the non-obese group as to the age, vital capacity, tidal volume, forced vital capacity, and forced expiratory volume in one second. However, the obese group presented a greater inspiratory reserve volume (2.44 ± 0.47 L vs. 1.87 ± 0.42 L), a lower expiratory reserve volume (0.52 ± 0.32 L vs. 1.15 ± 0.32 L), and a maximal voluntary ventilation (108.5 ± 13.3 L/min vs. 122.6 ± 19.8 L/min) than the non-obese group, respectively. CONCLUSION: The alterations evidenced in the components of the vital capacity (inspiratory reserve volume and expiratory reserve volume) suggest damage to the chest mechanics caused by obesity. These factors probably contributed to a reduction of the maximal voluntary ventilation.

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Section: Introductionmentioning

confidence: 99%

The Impact of Obesity on Pulmonary Function in Adult Women

Costa

Barbalho

Miguel

et al. 2008

Clinics

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“…2 Obesity is a chronic disease characterized by excessive body fat that causes damage to the individual's health and is associated with comorbidities such as diabetes and hypertension and vascular dysfunction. [3][4][5][6][7][8] Obesity in adults is defined by the World Health Organization (WHO) as having a body mass index (BMI) that is greater than or equal to 30 kg/m. The normal BMI range is between 18.5 and 24.99 kg/m.…”

Section: Introductionmentioning

confidence: 99%

Effect of obesity on lung function test among adults

Salvi¹,

Moradia²

2020

Int J Adv Med

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Background: Obesity is a chronic disease characterized by excessive body fat that causes damage to the individual’s health and is associated with comorbidities such as diabetes and hypertension and vascular dysfunction. This cross-sectional study was carried out with the objective of evaluating the effect of obesity on lung function test in obese but otherwise healthy adults.Methods: It was a cross-sectional study carried out at tertiary care institute of Gujarat, India. It was conducted over a period of 5 months. A total of 240 adult healthy subjects of both sexes were selected randomly belonging to varying socio-economic status. The study subjects were divided into 3 categories (normal body mass index i.e. BMI, overweight, obese). BMI were calculated for the randomly selected subjects from each list till the desired number in each BMI group were attained. Four respiratory parameters viz. forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory volume in 3 seconds (FEV3), and maximum voluntary ventilation (MVV) were used to assess their lung functions.Results: Two hundred and forty subjects (each group having n=80). The mean age of group I, group II and group III were 27.45±6.37, 28.18±6.42 and 28.98±6.74 respectively. Lung volumes showed significant difference in relation to the BMI. FVC and FEV1 show significant decrease. Group III verses group I (p˂0.001 and p˂0.017 respectively) FEV3 showed significant difference between group I and group III and between group II and group III (p˂0.001). MVV was significantly lower in group III when compared to group I.Conclusions: There is decline in pulmonary function in obese as compared to normal weight adults. These findings suggest deleterious effects on ventilatory mechanics caused by obesity, due to probable lung compression (reduction in the expiratory reserve volume i.e. ERV), leading to a compensatory increase in the inspiratory reserve volume (IRV) in an attempt to maintain a constant vital capacity (VC).

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“…[1] Obesity is a chronic condition characterized by excessive body fat that causes damage to the individual's health and is associated with comorbidities such as diabetes and hypertension and vascular dysfunction. [4,5] Some of the respiratory symptoms commonly associated with obesity include wheeze, dyspnea, and orthopnea are also increased as BMI increases. [6] Obesity is an important risk factor and disease modifier of many respiratory conditions such as asthma, [7] chronic obstructive pulmonary disease, [8] obstructive sleep apnea, and obesity hypoventilation syndrome.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2020

IJPBA

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Background: Obesity is a chronic disease characterized by the excessive accumulation of body fat which is associated with comorbidities. It is a growing health issue worldwide. Obesity is known to have significant effects on respiratory function and obese patients commonly report respiratory complaints requiring pulmonary function tests. Objectives: The objectives of the study were to determine the effects of obesity on pulmonary function in overweight and obese adults who were non-smokers and did not have any respiratory diseases. Materials and Methods: This cross-sectional study was carried out among 181 healthy adults of both sexes between 20 and 60 years, those attended master health checkup and medicine outpatient department. The study participants were divided into three body mass index (BMI) groups according to the WHO BMI classification. Forced vital capacity in liters (FVC), forced expiratory volume in the first second in liters (FEV1), FVC/FEV1, peak expiratory flow rate in liter/min (PEFR), and forced expiratory flow (FEF)25-75% were recorded. These three BMI groups were compared using one-way ANOVA, correlation was assessed by Pearson's "r." Linear regression analysis was applied. Results: Significant differences in lung volumes were found in three BMI groups. Obese and overweight subjects had significantly lower FVC, FEV1, FEF25%-75%, and PEFR (P < 0.0001) as compared to normal weight subjects. However, there was no statistically significant difference found in FEV1/FVC ratio. There were significant linear relationships between obesity and pulmonary function. BMI had significant negative linear association at the level of P < 0.001 with FVC% (r = −0.355), FEV1% (r = −0.361), FEF25%-75% (−0.432), and PEFR (r = −0.501). FEV1/FVC ratio was negatively correlated, but statistically not significant. Conclusion: BMI has a detrimental effect on pulmonary functions in overweight and obese subjects. Reduction in FVC and FEV1 was the most representative findings among the overweight and obese subjects, suggesting the presence of a restrictive respiratory pattern associated with obesity. It might be due to decrease in lung and chest wall compliance and increase in work of breathing.

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Obesity, Inflammation, Vascular Reactivity, and Cardiocirculatory Events

Cited by 4 publications

References 13 publications

The Impact of Obesity on Pulmonary Function in Adult Women

The Impact of Obesity on Pulmonary Function in Adult Women

Effect of obesity on lung function test among adults

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