Renal Parenchymal Malacoplakia With Pleural Effusion

Cury, José; Coelho, Rafael F.; Franco, Mônica Regina; Srougi, Miguel

doi:10.1590/s1807-59322007000100013

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…A unifocal renal lesion is uncommon and can resemble a necrotic renal cell carcinoma [1]. Differential diagnoses in radiologic studies include local abscess, granuloma, xanthogranulomatous pyelonephritis, lymphoma and multifocal primary or metastatic tumors [8]. …”

Section: Introductionmentioning

confidence: 99%

Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report

et al. 2012

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IntroductionMalakoplakia is an uncommon chronic inflammatory condition that has a gross and microscopic appearance resembling that of xanthogranulomatous pyelonephritis. It is characterized by distinctive Michaelis-Gutmann bodies. Malakoplakia can affect any organ system but genitourinary tract involvement is the most common, particularly in immunocompromised individuals. Very rare cases have been reported to present as a unifocal lesion mimicking a renal tumor.Case presentationWe report a case of renal malakoplakia in a 55-year-old Iranian man with a past history of recurrent urinary tract infections who presented with left flank pain. An ultrasound study showed a large solid left renal mass, and he underwent a left radical nephrectomy with a clinical diagnosis of a renal tumor. Pathology slides revealed the diffuse infiltration of sheets of Periodic Acid Schiff-positive histiocytes in his renal parenchyma; these cells showed strong immunoreactivity for CD 68. The final diagnosis was renal malakoplakia.ConclusionRenal malakoplakia must be kept in mind for patients presenting with a renal mass and a history of long-term recurrent renal infections or renal failure. The large, rapidly growing nodules of malakoplakia may mimic renal cell carcinoma in imaging studies. In these cases, a true cut needle biopsy may help the correct diagnosis and prevent unnecessary surgery.

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Section: Introductionmentioning

confidence: 99%

Renal malakoplakia presenting as a renal mass in a 55-year-old man: a case report

et al. 2012

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Malakoplakia Presenting as a Mass in the Transplanted Kidney

et al. 2021

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Malakoplakia is a rare inflammatory condition that can affect many organ systems, including the genitourinary tract. It is associated with impaired immune function. Isolated renal parenchymal involvement has been reported in very few cases. Urinary tract and digestive malakoplakia have been reported in transplant recipients, but the involvement of transplant itself is rare. Variable clinical manifestations and nonspecific radiological appearance make the diagnosis difficult. The differential diagnosis includes infective etiologies and malignancy. We report a case of renal allograft malakoplakia, mimicking as a malignancy on 18F-FDG PET/CT.

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