FREQUENCY OF THE ALLELIC VARIANT (Trp8Arg/Ile15Thr) OF THE LUTEINIZING HORMONE GENE IN A BRAZILIAN COHORT OF HEALTHY SUBJECTS AND IN PATIENTS WITH HYPOGONADOTROPIC HYPOGONADISM
Abstract:PURPOSE:To evaluate the frequency of allelic variant Trp8Arg/Ile15Thr in the luteinizing hormone β-subunit gene in a Brazilian population of healthy subjects and in patients with hypogonadotropic hypogonadism. SUBJECTS AND METHODS: Two hundred and two adults (115 women) with normal sexual function and 48 patients (24 women) with hypogonadotropic hypogonadism underwent a molecular study of the the luteinizing hormone β-subunit gene using a polymerase chain reaction technique followed by enzymatic digestion with… Show more
Although data are accumulating with evidence suggesting that the ovarian response to COH is mediated by various polymorphisms, the optimal biomarkers and the efficacy of the tests still remain to be evaluated.
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