Antiphospholipid Antibodies, Thrombosis, and Adenocarcinoma

Schiavo, Nádia; Lottermann, Andrei Lemos; Costa, Fernanda pires; Staub, Henrique Luiz

doi:10.1590/s1807-59322005000300012

Cited by 3 publications

(2 citation statements)

References 13 publications

(17 reference statements)

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“…High levels of aCL antibodies are involved with thrombosis and recurrent pregnancy loss, and can also be present in human cancer patients. [24][25][26][27][28] The dogs neither had clinical signs of thrombosis, nor were they pregnant at the time of blood sampling or there were indication of increased pregnancy morbidity in this small population of dogs. Although the extensive examination protocol of the dogs did not detect tumors, occult neoplasia could not fully be excluded.…”

Section: Discussionmentioning

confidence: 99%

The Presence of Antiphospholipid Antibodies in Healthy Bernese Mountain Dogs

Nielsen

Wiinberg

Kjelgaard‐Hansen

et al. 2011

Veterinary Internal Medicne

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Background: The role of antiphospholipid antibodies in the prolonged activated partial thromboplastin time (aPTT) previously identified in healthy Bernese Mountain Dogs remains unknown. In people, an isolated prolonged aPTT without evidence of bleeding might be because of a thrombophilic condition caused by antiphospholipid antibodies.Objective: To examine if prolonged aPTT in healthy Bernese Mountain Dogs is because of antiphospholipid antibodies.Animals: Twenty-two healthy Bernese Mountain Dogs and 10 healthy adult dogs of various breeds. Methods: Prospective case control study. Healthy Bernese Moutain Dogs were examined twice over 6 months. Dogs were investigated for the presence of lupus anticoagulants and anticardiolipin (aCL) antibodies by the use of multiple aPTT tests with low and high lupus anticoagulant sensitivities, a mixing study, and an ELISA test for aCL antibody optical density to detect solid phase antiphospholipid antibodies.Results: In all, 15 of 22 healthy Bernese Mountain Dogs were positive for lupus anticoagulants. The Bernese Mountain Dogs had markedly higher levels of aCL antibodies compared with the control dogs (P = .006). In all, 7 of 21 of the Bernese Mountain Dogs were positive for both lupus anticoagulants and aCL antibodies, whereas 4 of 21 Bernese Mountain Dogs were negative for both.Conclusions and Clinical Importance: Lupus anticoagulants and aCL antibodies could be the cause of prolonged aPTT in healthy Bernese Mountain Dogs. The importance of the antiphospholipid antibodies in the dogs remains unknown.

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Section: Discussionmentioning

confidence: 99%

The Presence of Antiphospholipid Antibodies in Healthy Bernese Mountain Dogs

Nielsen

Wiinberg

Kjelgaard‐Hansen

et al. 2011

Veterinary Internal Medicne

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“…Indeed, recent reports describe anti-lipid antibody production in cancer patients [15]. In one study, a patient with breast cancer and another with colorectal carcinoma experienced dramatic exacerbation of their pre-existing anti-phospholipid syndrome after surgery [16].…”

Section: Array Validationmentioning

confidence: 99%

Characterization of new serum biomarkers in breast cancer using lipid microarrays

Yonekubo

Esechie

et al. 2010

Tumor Biol.

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Breast cancer is the most common form of cancer among women. Compared with other serum polypeptides, autoantibodies have many appealing features as biomarkers including sensitivity, stability, and easy detection. Anti-lipid autoantibodies are routinely used in the diagnosis of autoimmune diseases, but their potential for cancer diagnosis has not been explored. Dysregulation of cellular signaling in cancer cells would be expected to lead to irregular metabolism of many lipids, which could be sensed by the immune system and cause the production of autoantibodies. Discovery of anti-lipid antibodies could be used as biomarkers for early breast cancer diagnosis. We describe here a more sensitive and accurate method for lipid microarray detection using dual fluorescent labeling, and used it to examine global anti-lipid profiles in the MMTV-Neu transgenic breast cancer model. We conclude that, at the current technology, lipid microarray is not a preferred method for anti-lipid antibody detection in breast cancer animal models. Our result will help the future application of lipid microarrays in identifying anti-lipid autoantibodies in breast cancer and other human diseases.

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Anticorps antiphospholipides et cancer

Scrobohaci¹

2008

Pathologie Biologie

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Antiphospholipid Antibodies, Thrombosis, and Adenocarcinoma

Cited by 3 publications

References 13 publications

The Presence of Antiphospholipid Antibodies in Healthy Bernese Mountain Dogs

The Presence of Antiphospholipid Antibodies in Healthy Bernese Mountain Dogs

Characterization of new serum biomarkers in breast cancer using lipid microarrays

Anticorps antiphospholipides et cancer

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