The Level of Nicotine Dependence Is an Independent Risk Factor for Cancer. A Case Control Study

Deheinzelin, Daniel; Lourenço, Maria Helena; Costa, C; Younes, Riad Naim

doi:10.1590/s1807-59322005000300007

Cited by 14 publications

(13 citation statements)

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“…Our study showed that among current smokers, smoking addiction was associated with UADT SCC risk. Similar to the previous study on all cancers by Deheinzelin et al ., in our study we found an effect size of 3.83 (95% CI = 2.56–5.73) for UADT SCC risk with a modified Fagerström score of 3–7. Furthermore, the ORs for UADT cancers ranged 1.65–2.22 for <60 min to first cigarette after waking up when compared to >60 min, which is similar to the associations reported by Muscat et al .…”

Section: Discussionsupporting

confidence: 91%

“…To date, in the only published study on Fagerström scores and cancer risk, Deheinzelin et al . reported an association between Fagerström Tolerance Questionnaire score ≥7 and overall cancer risk [pack‐year adjusted odds ratio (OR) = 3.45, 95% confidence interval (CI): 1.52–7.83] in a smoking cessation group . A total of 54 cases with a variety of histology and cancer sites were included in the study.…”

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confidence: 99%

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Smoking addiction and the risk of upper-aerodigestive-tract cancer in a multicenter case-control study

et al. 2013

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Although previous studies on tobacco and alcohol and the risk of upper-aerodigestive-tract (UADT) cancers have clearly shown dose-response relations with the frequency and duration of tobacco and alcohol, studies on addiction to tobacco smoking itself as a risk factor for UADT cancer have not been published, to our knowledge. The aim of this report is to assess whether smoking addiction is an independent risk factor or a refinement to smoking variables (intensity and duration) for UADT squamous cell carcinoma (SCC) risk in the multicenter case-control study (ARCAGE) in Western Europe. The analyses included 1,586 ever smoking UADT SCC cases and 1,260 ever smoking controls. Addiction was measured by a modified Fagerstr€ om score (first cigarette after waking up, difficulty refraining from smoking in places where it is forbidden and cigarettes per day). Adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for UADT cancers with addiction variables were estimated with unconditional logistic regression. Among current smokers, the participants who smoked their first cigarette within 5 min of waking up were two times more likely to develop UADT SCC than those who smoked 60 min after waking up. Greater tobacco smoking addiction was associated with an increased risk of UADT SCC among current smokers (OR 5 3.83, 95% CI: 2.56-5.73 for score of 3-7 vs. 0) but not among former smokers. These results may be consistent with a residual effect of

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

Smoking addiction and the risk of upper-aerodigestive-tract cancer in a multicenter case-control study

et al. 2013

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“…A study confirms these findings, with a significantly higher FTQ in cancer patients (7.5) when compared with controls (6.3). An FTQ > 7 (high) was found in 73.2% of cancer cases, against 43.5% in the control group (17) .…”

Section: Discussionmentioning

confidence: 78%

Fatores de risco para câncer de colo do útero segundo resultados de IVA, citologia e cervicografia

Anjos

Vasconcelos²,

Franco³

et al. 2010

Rev. esc. enferm. USP

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Portuguese / English: www.scielo.br/reeusp RESUMO Este estudo objetivou avaliar a associação entre fatores de risco para câncer de colo do útero e lesões cervicais por HPV comparando-se os resultados da inspeção visual com o ácido acético (IVA), a citologia e a cervicografia. Realizou-se pesquisa de prevalência com 157 mulheres de um centro de saúde de Fortaleza, no período de junho a setembro de 2006. Utilizou-se o SPSS para codificar os dados. Realizaram-se inferências por meio de testes estatísticos ( 2 = quiquadrado e RV= razão de verossimilhança). IVA, cervicografia e citologia obtiveram 43,3%, 10,19% e 3,2% de resultados alterados, respectivamente. As variáveis com importante associação às lesões cervicais na IVA foram: idade menor de 20 anos (p= 0,0001); um ou mais parceiros nos últimos três meses (p= 0,015); uso de contraceptivos (p= 0,0008); presença de corrimento vaginal (p= 0,0001); e processo inflamató-rio moderado ou acentuado (p= 0,0001). Na citologia: baixa escolaridade (p= 0,0001) e elevado pH (p= 0,001). Não se encontrou associação significante na cervicografia. DESCRITORES ABSTRACTThis study aimed to evaluate the association between risk factors for uterine cervical neoplasms and cervical lesions by HPV by comparison of the visual inspection with acetic acid (VIA), cytology and cervicography results. A prevalence research was made with 157 women in a health center of Fortaleza in the period of June to September 2006. The SPSS program was used to codify the data. Inferences were made through statistical tests ( 2 = chi square and LR= likelihood ratio). The VIA, cervicography and cytology obtained 43.3%, 10.19% and 3.2% of altered results. The variables with important association to cervical lesions in the VIA were: aged less than 20 years old (p= 0.0001); one or more partners in the last three months (p= 0.015); use of contraceptives (p = 0.0008); presence of vaginal discharge (p= 0.0001) and moderate or accentuated inflammatory process (p= 0.0001). In the cytology: low instructional level (p= 0.0001) and high pH (p= 0.001). It wasn't found any significant association in the cervicography. KEY WORDS RESUMENEste estudio objetivó evaluar la asociación entre factores de riesgo para cáncer de cuello de útero y lesiones cervicales por HPV, según comparación entre los resultados de la inspección visual con ácido acético (IVA), citología y cervicografía. Se realizó investigación de prevalencia, con 157 mujeres en un centro de salud de Fortaleza-CE-Brasil, en el período de junio a setiembre de 2006. Se utilizó el SPSS para codificar los datos. Se realizaron inferencias a través de tests estadísticos ( 2 = Qui-cuadrado y RV= razón de verosimilitud). La IVA, cervicografía y citología obtuvieron 43,3%, 10,19% y 3,2% de resultados alterados. Las variables con importante asociación a lesiones cervicales en la IVA fueron: edad menor a 20 años (p=0,0001), uno o más parejas en los últi-mos tres meses (p=0,015), uso de anticonceptivos (p=0,0008), presencia de vaginitis (p=0,0001) y pH elevado (p=0,001). No ...

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“…Dental surgeons and academics can help to control smoking as they are in frequent contact with their patients and can readily identify smokers and help principally those who have the intention of giving up the habit, in respect of the deleterious effects of tobacco on oral health 21 .…”

Section: Discussionmentioning

confidence: 99%

Measure nicotine dependence by the fagerström test for nicotine dependence

Weber

Hatschbach

Pithan

et al. 2017

RGO, Rev. Gaúch. Odontol.

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Objective To assess the level of nicotine dependence of smokers in a university dental clinic in southern Brazil using the Fagerström Test for Nicotine Dependence and identify those who would like to quit smoking. Methods Results The mean age of the smokers was 47.90 and most had had up to eight years of schooling, and had a family income of less than 1,000 Brazilian Reais. The degree of nicotine dependence was classified, by the mean, 4.45 ± 2.53 points (±SD). There was a significant correlation between nicotine dependence and the number of cigarettes smoked per day. ConclusionThe 1% sodium hypochlorite solution caused least damage to the denture structure, not leading to decrease of the superficial microhardness. Métodos Trata-se de um estudo transversal analítico, com amostragem probabilística, composta por 93 adultos de ambos os sexos. Utilizou-se o Teste de Fagerström para Dependência de Nicotina e as informações foram coletadas por quatro pesquisadores. Os dados foram analisados por meio de estatística descritiva e inferencial (Qui-quadrado), sendo empregado o nível de significância de 5%). ResultadosOs fumantes apresentaram média de idade de 47,90 anos, sendo que a maioria possui até ensino fundamental e renda familiar de 1000 reais. O grau de dependência nicotínica foi classificado, em média, como escore de 4,45 ± 2,53 pontos (± dp). Houve associação entre nível de dependência e número de cigarros fumados por dia. ConclusãoPode-se concluir que 36,6% da amostra apresentam dependência elevada ou muito elevada. Esse grupo pode necessitar de terapia medicamentosa para auxiliar na cessação do tabagismo, salientando-se a importância dos grupos de apoio com esse fim, uma vez que 95% da amostra gostaria de parar de fumar.

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The Level of Nicotine Dependence Is an Independent Risk Factor for Cancer. A Case Control Study

Cited by 14 publications

References 24 publications

Smoking addiction and the risk of upper-aerodigestive-tract cancer in a multicenter case-control study

Smoking addiction and the risk of upper-aerodigestive-tract cancer in a multicenter case-control study

Fatores de risco para câncer de colo do útero segundo resultados de IVA, citologia e cervicografia

Measure nicotine dependence by the fagerström test for nicotine dependence

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