In vitro antifungal susceptibility of Candida spp. oral isolates from HIV-positive patients and control individuals

Brito, Graziella Nuernberg Back; Inocêncio, Aline Cássia; Querido, Silvia Maria Rodrigues; Jorge, Antônio Olavo Cardoso; Koga-Ito, Cristiane Yumi

doi:10.1590/s1806-83242011005000001

Cited by 31 publications

(33 citation statements)

References 19 publications

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“…8 In this study, patients in the EG had a higher incidence of non-albicans species in saliva as compared with patients in the CG. Several studies have reported that predisposing factors such as mouth breathing 12 and HIV-infection 13 may increase the variability of Candida species in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Candida spp. adherence to oral epithelial cells and levels of IgA in children with orthodontic appliances

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Candida spp. adherence to oral epithelial cells and levels of IgA in children with orthodontic appliances

et al. 2014

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“…The currently accepted treatment regimens for oral candidiasis are clotrimazole (lozenges or troches), nystatin (tablets, lozenges, or pessaries), or miconazole (oral gel or buccal tablets) (14), as well as amphotericin B, fluconazole, flucytosine, and ketoconazole (15,16). The main disadvantage of these common antifungals for candidiasis is their low substantivity and their potential side effects, especially on the oral ecosystem.…”

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confidence: 99%

Sustained Release of a Novel Anti-Quorum-Sensing Agent against Oral Fungal Biofilms

Feldman

Shenderovich

Al-Quntar

et al. 2015

Antimicrob Agents Chemother

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b Thiazolidinedione-8 (S-8) has recently been identified as a potential anti-quorum-sensing/antibiofilm agent against bacteria and fungi. Based on these results, we investigated the possibility of incorporating S-8 in a sustained-release membrane (SRM) to increase its pharmaceutical potential against Candida albicans biofilm. We demonstrated that SRM containing S-8 inhibits fungal biofilm formation in a time-dependent manner for 72 h, due to prolonged release of S-8. Moreover, the SRM effectively delivered the agent in its active form to locations outside the membrane reservoir. In addition, eradication of mature biofilm by the SRM containing S-8 was also significant. Of note, S-8-containing SRM affected the characteristics of mature C. albicans biofilm, such as thickness, exopolysaccharide (EPS) production, and morphogenesis of fungal cells. The concept of using an antibiofilm agent with no antifungal activity incorporated into a sustained-release delivery system is new in medicine and dentistry. This concept of an SRM containing a quorum-sensing quencher with an antibiofilm effect could pave the way for combating oral fungal infectious diseases.

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“…All three mouthwash treatments had low incidences of oral fungal infections, ranging from zero to 4.3%. Nystatin, a broad spectrum anti-fungal agent and enhancer of membrane permeability, is efficacious in treating oral fungal infections [15][16][17]25], but there is no consensus on the concentration of nystatin. We chose 1% nystatin for our study.…”

Section: Discussionmentioning

confidence: 99%

“…Another possibility is nystatin, which is a broad-spectrum antifungal agent that is effective when focally administered in ointment and lozenge and when used for prevention with nystatin mouthwash [15][16][17]. When patients receiving hematopoietic stem cell transplantation were given amphotericin B or nystatin mouthwash prophylactically, fungi in the throat were markedly reduced, and nystatin had superior taste and patient compliance compared with amphotericin B [18].…”

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Prospective trial finds nystatin mouthwash effective prophylaxis for pulmonary invasive fungal infections that originate in the throat of patients with hematologic malignancies

Jiang²,

Wu³

2013

neo

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We investigated the source of fungi in the lungs of patients with hematological malignancies who had invasive pulmonary fungal infections (IPFI). We also conducted a prospective study to evaluate the efficacy of different mouthwash solutions in preventing IPFI in patients with hematologic malignancies. In order to determine the source of fungi in the lungs of 30 patients with hematologic malignancies who had IPFI, we collected samples from sites with suspected fungal infection and used PCR and sequencing for pathogen identification. For the prospective study, we enrolled 158 patients with hematological malignancies who had IPFI and randomly assigned them to one of three mouthwash groups: 1% nystatin, 2.5% sodium bicarbonate, or normal saline. Fungal staining and incidence of IPFI, oral fungal infection, and intestinal fungal infection were evaluated. We showed that 96.7% of the fungi isolated from the throats and the lungs were identical; 76.9% of the fungi from the lungs and digestive tracts were identical and, 84.6 % of the fungi from the throats and digestive tract were identical. Patients using 1% nystatin had lower incidence of IPFI (1.6%) and fungal enteritis (1.6%) than those using sodium bicarbonate (16.3% and 14.3%) or normal saline (27.7% and 12.8%). All treatments had low incidences of oral fungal infections (0 to 4.3%). Our data showed that fungi originating from mouth and throat cause IPFI. We also showed that use of a prophylactic mouthwash containing 1% nystatin was effective in preventing IPFI in patients with hematological malignancies.

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In vitro antifungal susceptibility of Candida spp. oral isolates from HIV-positive patients and control individuals

Cited by 31 publications

References 19 publications

Candida spp. adherence to oral epithelial cells and levels of IgA in children with orthodontic appliances

Candida spp. adherence to oral epithelial cells and levels of IgA in children with orthodontic appliances

Sustained Release of a Novel Anti-Quorum-Sensing Agent against Oral Fungal Biofilms

Prospective trial finds nystatin mouthwash effective prophylaxis for pulmonary invasive fungal infections that originate in the throat of patients with hematologic malignancies

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