Periodontal condition in patients with rheumatoid arthritis

Abstract

The purpose of this clinical study was to investigate if periodontal disease and rheumatoid arthritis (RA) are associated. The study included 39 RA patients (test group) and 22 age-and gender-matched healthy individuals (control group). Questionnaires on general and oral health were applied and a complete periodontal exam, including visible plaque, marginal bleeding, attachment loss (AL) and number of teeth present, was also performed by a single calibrated examiner. Diabetes mellitus patients and smokers were excluded. RA patients had fewer teeth, higher prevalence of sites presenting dental plaque and a higher frequency of sites with advanced attachment loss. Although the prevalence of dental plaque was higher in the test group (Chi-square test, p = 0.0006), the percentage of sites showing gingival bleeding was not different (Fisher's exact test, p > 0.05). Based on our results, we suggest that there is an association between periodontal disease and RA.

Periodontal status of rheumatoid arthritis patients in khartoum state

“…The results agree with Ishi et al [27], Mikael et al [29] and Depablo et al, [30] and this may be due to increased secretion of pro-inflammatory mediators in both conditions.…”

“…This is similar to the findings reported by Mercado et al [21] and Ishi et al [27], but it disagrees with the findings by Yaniv et al [26] which found higher prevalence of sites with gingival inflammation in the RA patients compared with the control group.…”

“…Thus, the general concept that RA patients tend to have more plaque deposits because of limited dexterity was not validated. However Ishi et al [27] and Ezel et al [28] demonstrate a high prevalence of sites with dental plaque in their studies, and this may be explained by the fact that those patients directed their attention mainly to their serious illness while neglecting their oral health.…”

Association between Oral Health Status and Rheumatoid Arthritis

“…치주염과 류마티스 관절염은 항염증성(anti-inflammatory)과 전염증성(proinflammatory) 사이토카인의 불균형으로 나타나며 조직을 손상시킨다. 이러한 맥락에서 본다면 이 두 가지 질환은 염 증성 사이토카인에 의해 매개되는 골 파괴, 즉 염증을 중심 적인 연결고리로 보는 것과 관련될 수 있다 13) . 병리학적 진 행과정, interleukin 1 (IL-1), 자가항체인 류마티스 인자 (rheumatoid factor) 및 항CCP 항체(anti-cyclic citrullinated peptide antibodies) 또한 공유하고 있는 것으로 알려 져 있다 1,14) .…”

Effect of periodontal treatment on the clinical parameters of patients with rheumatoid arthritis: study protocol of the randomized, controlled ESPERA trial

“…A study has reported that the frequency of RA is significantly higher in patients with periodontal disease than in subjects without periodontitis (3.95% versus 0.66%) [17]. Other studies have reported a higher incidence of missing teeth, dental plaque, greater periodontal pocket depth, or worse clinical attachment levels in patients with RA [18-20]. On the one hand, it is likely that patients with RA may encounter more difficulties in achieving good oral health because of joint pain or functional limitation [20,21], while on the other hand, it is hypothesized that periodontitis could be a risk factor or an aggravating factor for RA.…”