Enamel matrix proteins associated with GTR and bioactive glass in the treatment of class III furcation in dogs

Abstract

This study investigated, both histologically and histometrically, the efficacy of enamel matrix derived proteins (EMD) associated with bioactive glass (BG) and an absorbable membrane in the treatment of class III furcation defects in mongrel dogs. After surgical defect creation and chronification, the lesions were randomly divided into three groups according to the treatment employed: Test Group 1--EMD + BG + membrane, Test Group 2--EMD + membrane and Control Group--BG + membrane. After a 90-day healing period, the dogs were sacrificed. The descriptive analysis and the histometric data showed similar results for the experimental groups in all studied parameters (MANOVA, p > 0.05). The association of Emdogain with bioglass and GTR, or with GTR only, showed similar results when compared with the ones obtained with bioglass associated with membrane in the treatment of class III furcation defects in dogs. The three modalities of treatment showed partial filling of the furcations, with bone and cementum regeneration limited to the apical portion of the defects.

Histological and Histomorphometric Study of the Effect of Strontium Ranelate on the Healing of One-Wall Intrabony Periodontal Defects in Dogs

“…Some techniques have been used in association, aiming to increase their effect on periodontal regeneration [16,17].…”

Application of autologous periosteal cells for the regeneration of class III furcation defects in Beagle dogs

“…The alveolar bone from each premolar ( 2 P 2 , 3 P 3 , 4 P 4 ) was removed, creating a ''horizontal'' pattern of bone loss. According to the protocols by Yan et al (2003) and Fernandes et al (2005), the furcation defects were approximately 3 mm wide and 4 mm high and were filled with gutta-percha to promote inflammative reaction. Granulation tissue was removed and the root surface was thoroughly debrided by curets.…”

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

“…The advent of regenerative approaches in contemporary periodontics has increased patient's treatment options and enhanced the long-term prognosis of many teeth that have advanced periodontal destruction. Regenerative procedures have been evaluated in several studies using grafting materials, tooth root surface conditioning, guided tissue regeneration and application of growth factors [1][2][3][4].…”

“…They 2 doi: 10.7243/2050-1218- [2][3][4][5][6][7][8][9][10][11] have been suggested to represent a potential aid in an attempt to regenerate the periodontium [9]. Growth factors that seem to play an important role in periodontal and bone wound healing are platelet derived growth factor (PDGF), insulin-like growth factor (IGF) combined with PDGF and transforming growth factor β (TGF-β) [9].…”