Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva

Koga-Ito, Cristiane Yumi; Martins, Clélia Aparecida de Paiva; Balducci, Ivan; Jorge, Antônio Olavo Cardoso

doi:10.1590/s1806-83242004000400014

Cited by 49 publications

(47 citation statements)

References 21 publications

(15 reference statements)

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“…The discrepancy in the results could be due to differences in the methodology. It is important to note that the use of purified antigens derived from cariogenic microorganisms is likely to provide a more reliable method for evaluating the contribution of salivary IgA to caries resistance [Bolton and Hlava, 1982] compared to analysis using nonpurified antigens and may explain the difference between our data and those of Koga-Ito et al [2004].…”

Section: Discussionmentioning

confidence: 87%

“…While some studies show that high anti-MS antibody activity is associated with caries presence in children [de Farias and Bezerra, 2003;Koga-Ito et al, 2004], others show the opposite [Bolton and Hlava, 1982;Kirtaniya et al, 2009]. Moreover, the identification of factors involved in mutans streptococcal colonization could be a key point in the pathogenesis of ECC that can be targeted for caries prevention in early childhood.…”

mentioning

confidence: 99%

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Immunological and Microbiologic Changes during Caries Development in Young Children

Parisotto

King²,

Duque

et al. 2011

Caries Res

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We explored the association between caries development, colonization with caries-associated microflora, and immunity as children begin the transition to mixed dentition. Forty children received dental examinations at 3–4 years of age, repeated a year later. Children were grouped into caries-free (n = 23; CF) and caries-active (n = 17; CA ≧3 new lesions on follow-up). Salivary IgA and IgA antibody to Streptococcus mutans virulence epitopes were measured by Luminex assay. Mutans streptococci (MS), lactobacilli and total microorganisms were enumerated on selective media from plaque samples. There was no significant difference in baseline levels of MS or lactobacilli between CF and CA groups. However, both MS and lactobacilli levels were higher at follow-up in the CA group. Furthermore, children with detectable lactobacilli at baseline had significantly higher caries risk. Salivary IgA concentrations increased significantly in both groups during the study. Both CF and CA groups also displayed significant increases in salivary IgA antibody levels to glucosyltransferase, glucan-binding protein (Gbp) and antigen I/II salivary binding region. CF antibody levels to seven peptides associated with domains of biological importance increased at follow-up, in contrast to increases to only three peptides in CA saliva samples. Multivariate modeling showed that a lower baseline level of salivary IgA anti-GbpB was associated with higher caries risk. These data indicate that MS and lactobacilli are associated with caries in this population, that the secretory immune system is undergoing significant maturation during this period, and that the breadth of mucosal IgA response to epitopes of S. mutans virulence components may influence the degree to which these cariogenic microorganisms can cause disease.

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Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 99%

Immunological and Microbiologic Changes during Caries Development in Young Children

Parisotto

King²,

Duque

et al. 2011

Caries Res

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“…S. mutans is detected in a vast majority (>90%) of adults regardless of their country, race, sex, eating habits, or presence of dental caries [27]. Several clinical studies have reported a clear relationship between S. mutans levels in the saliva and the development of dental caries in populations with a relatively high risk of dental caries [42,43]. To evaluate caries risk in terms of the bacterial factor, it is important to evaluate not only the total amount of S. mutans and S. sobrinus, but also the amounts of each.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Proportion of Cariogenic Bacteria Associated with Dental Caries

Gotouda¹,

Shinozaki-Kuwahara²,

Taguchi³

et al. 2017

Epidemiology

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Background: Public oral health surveys have shown that the prevalence of dental caries in adults is increasing worldwide, resulting in increased workload and costs of dental and other clinical oral health services. Total streptococci are broadly grouped into mutans streptococci and three other species. They constitute a majority of bacteria found in the mouth. Of the total streptococci, the group of bacteria that primarily causes dental caries is mutans streptococci, which consists of seven species. Streptococcus mutans (S. mutans) is the mutans streptococcus most strongly associated with dental caries. To date, no simple culture assay (kit) has been developed for detecting S. mutans using plaque samples for caries risk assessment. This study aimed to evaluate the association between S. mutans and dental caries in adults based on the number and proportion of cariogenic bacteria in toothbrush plaque samples by culture methods to obtain basic data to develop clinical and chairside culture assay for caries risk assessment.

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“…Karyojenik mikroorganizmaların diş sert yüzeylerine adezyonunu önlemekte ve glikoziltransferaz aktivitesini inhibe edebilmektedir. 25,26 Salgısal IgA'nın sentez ve salgılanmasının dü-zenlenmesi antijenik uyarılmanın yanında nöroen-dokrin kontrole de bağlıdır. 27 Bu durumda stres, egzersiz, hamilelik, menstrüel döngü ve farmakolojik müdahaleler de tükürük IgA seviyesini etkileyebilmektedir.…”

Section: Anti̇bakteri̇yel Protei̇nlerunclassified

Salivary Proteins and Effects on Dental Caries: Review

Özkoçak¹,

Karaarslan²,

Aytaç³

2017

Turkiye Klinikleri J Dental Sci

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Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva

Cited by 49 publications

References 21 publications

Immunological and Microbiologic Changes during Caries Development in Young Children

Immunological and Microbiologic Changes during Caries Development in Young Children

Evaluation of the Proportion of Cariogenic Bacteria Associated with Dental Caries

Salivary Proteins and Effects on Dental Caries: Review

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