Tuberculosis series

Silva, Denise Rossato; Mello, Fernanda Carvalho de Queiroz; Kritski, Afrânio Lineu; Dalcolmo, Margareth Pretti; Zumla, Alimuddin; Migliori, Giovanni Battista

doi:10.1590/s1806-37562018000020001

Cited by 9 publications

(14 citation statements)

References 20 publications

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“…According to Sweileh et al, 24 the Harvard University Partners in Health initiative and the Maugeri Scientific Institute are both in the top 10 most active institutions worldwide in terms of the number of published articles on MDR-TB 3 6 , 25 - 59 Additional examples of scientific collaboration identified in our study are those on basic research involving leading institutions in Mexico, Argentina, and Colombia, which are often funded by other international partners 60 64 …”

Section: Discussionmentioning

confidence: 85%

International collaboration among medical societies is an effective way to boost Latin American production of articles on tuberculosis

et al. 2019

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Objective: Most studies of tuberculosis originate from high-income countries with a low incidence of tuberculosis. A review of the scientific production on tuberculosis in Latin American countries, most of which are low- or middle-income countries (some with high or intermediate tuberculosis incidence rates), would improve the understanding of public health challenges, clinical needs, and research priorities. The aims of this systematic review were to determine what has been published recently in Latin America, to identify the leading authors involved, and to quantify the impact of international collaborations. Methods: We used PubMed to identify relevant manuscripts on pulmonary tuberculosis (PTB), drug-resistant tuberculosis (DR-TB), or multidrug-resistant tuberculosis (MDR-TB), published between 2013 and 2018. We selected only studies conducted in countries with an annual tuberculosis incidence of ≥ 10,000 reported cases and an annual MDR-TB incidence of ≥ 300 estimated cases, including Brazil, Peru, Mexico, Colombia, and Argentina. Articles were stratified by country, type, and topic. Results: We identified as eligible 395 studies on PTB and 188 studies on DR/MDR-TB-of which 96.4% and 96.8%, respectively, were original studies; 35.5% and 32.4%, respectively, had an epidemiological focus; and 52.7% and 36.2%, respectively, were conducted in Brazil. The recent Latin American Thoracic Association/European Respiratory Society/Brazilian Thoracic Association collaborative project boosted the production of high-quality articles on PTB and DR/MDR-TB in Latin America. Conclusions: Most of the recent Latin American studies on tuberculosis were conducted in Brazil, Mexico, or Peru. Collaboration among medical societies facilitates the production of scientific papers on tuberculosis. Such initiatives are in support of the World Health Organization call for intensified research and innovation in tuberculosis.

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Section: Discussionmentioning

confidence: 85%

International collaboration among medical societies is an effective way to boost Latin American production of articles on tuberculosis

et al. 2019

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“…Para atingir estas metas propostas, a OMS criou a End TB Strategy (Estratégia para Acabar com a Tuberculose), que tem como pilares o tratamento da tuberculose, tratamento preventivo intensificação das pesquisas e políticas arrojadas e sistemas de apoio, incluindo aparatos reguladores para as notificações de casos. (WHO, 2013;MILLARD et al, 2015;SILVA et al, 2018). O tratamento da MDR-TB é muito difícil e desafiador, com medicamentos de segunda linha que são menos eficazes e mais tóxicos quando comparados com tratamento com isoniazida e rifampicina.…”

Section: Assistência Farmacêuticaunclassified

“…Atualmente, a OMS recomenda o uso da bedaquilina para o tratamento da TB-MDR/XDR, mas só quando combinada com outros três fármacos eficientes. (SILVA et al, 2018;SILVA et al, 2019;NGUYEN et al, 2016).…”

Section: Perspectivas E Avanços No Desenvolvimento De Fármacos Contraunclassified

A Importância Do Profissional Farmacêutico No Processo De Cura Da Tuberculose/the Importance of Pharmaceutical Professionals in the Tuberculosis Healing Process

Nicoletti¹,

Antunes²,

Gurgel³

et al. 2020

BJD

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“…Mycobacterium tuberculosis is a member of the bacterial Mycobacteriaceae family and is known to cause tuberculosis (TB) in humans. The World Health Organization (WHO) reported the death of 1.7 million M. tuberculosis- infected persons in 2016 and estimated 10.4 million new cases of tuberculosis patients per year worldwide 1, 2. Emergence of multidrug-resistant strains makes the situation more ominous 1 .…”

Section: Introductionmentioning

confidence: 99%

“…The World Health Organization (WHO) reported the death of 1.7 million M. tuberculosis- infected persons in 2016 and estimated 10.4 million new cases of tuberculosis patients per year worldwide 1, 2. Emergence of multidrug-resistant strains makes the situation more ominous 1 . Therefore, to develop alternative treatments against both drug-susceptible and multidrug-resistant strains, discovery of novel and highly conserved drug targets is warranted.…”

Section: Introductionmentioning

confidence: 99%

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets

Mishra

Shankar

Jain

et al. 2019

Molecular Therapy - Nucleic Acids

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G-quadruplex structure forming motifs are among the most studied evolutionarily conserved drug targets that are present throughout the genome of different organisms and susceptible to influencing various biological processes. Here we report highly conserved potential G-quadruplex motifs (PGQs) in three essential genes ( espK , espB , and cyp51 ) among 160 strains of the Mycobacterium tuberculosis genome. Products of these genes are involved in pathways that are responsible for virulence determination of bacteria inside the host cell and its survival by maintaining membrane fluidity. The espK and espB genes are essential players that prevent the formation of mature phagolysosome and antigen presentation by host macrophages. The cyp51 is another PGQ-possessing gene involved in sterol biosynthesis pathway and membrane formation. In the present study, we revealed the formation of stable intramolecular parallel G-quadruplex structures by Mycobacterium PGQs using a combination of techniques (NMR, circular dichroism [CD], and gel electrophoresis). Next, isothermal titration calorimetry (ITC) and CD melting analysis demonstrated that a well-known G-quadruplex ligand, TMPyP4, binds to and stabilizes these PGQ motifs. Finally, polymerase inhibition and qRT-PCR assays highlight the biological relevance of PGQ-possessing genes in this pathogen and demonstrate that G-quadruplexes are potential drug targets for the development of effective anti-tuberculosis therapeutics.

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Tuberculosis series

Cited by 9 publications

References 20 publications

International collaboration among medical societies is an effective way to boost Latin American production of articles on tuberculosis

International collaboration among medical societies is an effective way to boost Latin American production of articles on tuberculosis

A Importância Do Profissional Farmacêutico No Processo De Cura Da Tuberculose/the Importance of Pharmaceutical Professionals in the Tuberculosis Healing Process

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets

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