The role of the Brazilian Tuberculosis Research Network in national and international efforts to eliminate tuberculosis

Kritski, Afrânio Lineu; Dalcolmo, Margareth Pretti; Mello, Fernanda C. Q.; Carvalho, Anna Cristina Calçada; Silva, Denise Rossato; Oliveira, Martha Maria de; Croda, Júlio

doi:10.1590/s1806-37562017000000435

Cited by 14 publications

(14 citation statements)

References 6 publications

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“…The End TB Strategy is based on the principles of “integrated care and prevention, focused on the patient; bold policies and support systems, with emphasis on the social protection of vulnerable populations; and intensification of research and innovation.” However, obstacles that impede the achievement of the proposed goals regarding TB still have to be overcome, especially in emerging countries. In this perspective, in 2017, Brazil signed a commitment term to develop a research agenda in the area of TB ( 4 - 5 ) .…”

Section: Introductionmentioning

confidence: 99%

Temporal pattern of tuberculosis cure, mortality, and treatment abandonment in Brazilian capitals

Sousa

Garcês

Pereira

et al. 2019

Rev. Latino-Am. Enfermagem

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Objective:to analyze the temporal pattern of tuberculosis cure, mortality, treatment abandonment in Brazilian capitals.Method:this is an ecological study whose data source was the Information System of Notifiable Diseases for Tuberculosis (Sistema de Informação de Agravos de Notificação para Tuberculose). For analysis of temporal evolution, regressions by join points were performed considering the annual percentage variation and the significance of the trend change with 95% confidence interval.Results:542,656 cases of tuberculosis were found, with emphasis on a 3% decrease per year in the cure rate for Campo Grande (interval: −5.0 - −0.9) and a 3.5% increase for Rio de Janeiro (interval: 1.9 - 4.7). Regarding abandonment, it decreased 10.9% per year in Rio Branco (interval: −15.8 - −5.7) and increased 12.8% per year in Fortaleza (interval: 7.6 - 18.3). For mortality, a decreasing or stationary tendency was identified, with a greater decrease (7.8%) for Porto Velho (interval:−11.0 - −5.0) and a lower one (2.5%) in Porto Alegre (interval:−4.5 - −0.6).Conclusion:the rates of cure and abandonment are far from the ones recommended by the World Health Organization, showing that Brazilian capitals need interventions aimed at changing this pattern.

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Section: Introductionmentioning

confidence: 99%

Temporal pattern of tuberculosis cure, mortality, and treatment abandonment in Brazilian capitals

Sousa

Garcês

Pereira

et al. 2019

Rev. Latino-Am. Enfermagem

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“… 7 One of the key endorsed research areas was regarding the investigation on host-pathogen interaction targeting new genetic, molecular, immunological, or metabolic markers, including the use of genotyping and the “omics” supporting epidemiology, new diagnostics methods, studies about new vaccines and more recently new drugs. 7 , 8 …”

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confidence: 99%

Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

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Salvato

Gomes

et al. 2021

Mem. Inst. Oswaldo Cruz

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Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS 6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.

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“…In addition, one of the best examples is the Brazilian Rede TB , which shows that the best research efforts, even in a large country as is Brazil, can collaborate to solve country-specific priorities and involve national tuberculosis programs and authorities in the plan. 7 - 11 However, as of today, no global tuberculosis network is operational enough to put together all of the abovementioned actors in order to support the fight against tuberculosis.…”

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confidence: 99%

Global TB Network: working together to eliminate tuberculosis

et al. 2018

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The role of the Brazilian Tuberculosis Research Network in national and international efforts to eliminate tuberculosis

Cited by 14 publications

References 6 publications

Temporal pattern of tuberculosis cure, mortality, and treatment abandonment in Brazilian capitals

Temporal pattern of tuberculosis cure, mortality, and treatment abandonment in Brazilian capitals

Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

Global TB Network: working together to eliminate tuberculosis

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