Rapidly growing pulmonary ground-glass nodule caused by metastatic melanoma lacking uptake on 18F-FDG PET-CT

Dalpiaz, Giorgia; Asioli, Sofia; Fanti, Stefano; Rea, Gaetano; Marchiori, Edson

doi:10.1590/s1806-37562017000000298

Cited by 6 publications

(16 citation statements)

References 5 publications

(8 reference statements)

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“…Conversely, the subsolid nodular pattern is rarely observed [3,4]. However, the literature reports that the subsolid appearance of pulmonary metastases is most commonly found in melanoma patients [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Subsolid pulmonary metastases from malignant melanoma typically exhibit a faster growth rate than primitive lung cancer [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Year Single or multiple subsolid nodules Okita et al [5] 2005 Multiple Kang et al [6] 2010 Single Mizuuchi et al [7] 2015 Single Dal Piaz et al [8] 2018 Single…”

Section: Authorsmentioning

confidence: 99%

“…Typically, pulmonary metastases from malignant melanoma occur as a single or multiple solid nodules on computed tomography (CT) images [3,4]. Rarely, pulmonary involvement in metastatic melanoma occurs as a single or multiple subsolid nodules [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

Borghesi

Tironi

Michelini

et al. 2019

European Journal of Radiology Open

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Malignant melanoma is an aggressive cancer with a high metastatic potential. Among the multiple sites of metastatic disease, the lung is one of the most frequently involved sites. Typically, pulmonary metastases from malignant melanoma occur as solid nodules. Rarely, pulmonary involvement in metastatic melanoma occurs as subsolid nodules. The present article describes an unusual case of a patient with malignant melanoma that developed two synchronous pulmonary metastases with two different densities on CT images (one solid and the other subsolid) and different morphological patterns on histologic images. The radiologic-pathologic correlation of these two patterns of presentation was also reported.

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Section: Discussionmentioning

confidence: 99%

“…Subsolid pulmonary metastases from malignant melanoma typically exhibit a faster growth rate than primitive lung cancer [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Year Single or multiple subsolid nodules Okita et al [5] 2005 Multiple Kang et al [6] 2010 Single Mizuuchi et al [7] 2015 Single Dal Piaz et al [8] 2018 Single…”

Section: Authorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

Borghesi

Tironi

Michelini

et al. 2019

European Journal of Radiology Open

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show abstract

“…This type of lesion may remain stable for years or show heterogeneous growth patterns with a trend toward a progressive increase in size over time [[1], [2], [3]]. More rarely, malignant SSNs may be the manifestation of primitive pulmonary lymphomas [4] or metastases from extrapulmonary malignancies, most often from malignant melanoma [[5], [6], [7], [8], [9]].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary metastases from malignant epithelioid schwannoma of the arm presenting as fast-growing subsolid nodules: Report of an unusual case

Borghesi

Bercich

Michelini

et al. 2019

European Journal of Radiology Open

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Subsolid pulmonary nodules (SSNs) may be the manifestation of benign and malignant conditions. Malignant SSNs usually correspond to the preinvasive or invasive lepidic growth of pulmonary adenocarcinomas. More rarely, malignant SSNs may be the manifestation of primitive pulmonary lymphomas or metastases from extrapulmonary malignancies. In the case of metastases from extrapulmonary malignancies, the SSNs exhibit more aggressive behavior with rapid growth in a short period of time. The present article describes the first case of pulmonary metastases presenting as fast-growing SSNs in a patient with malignant epithelioid schwannoma of the arm.

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Utility of whole exome sequencing analysis in differentiating intrapulmonary metastatic multiple ground-glass nodules (GGNs) from multiple primary GGNs

Zhou

Liu

et al. 2022

Int J Clin Oncol

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Purpose Clinical evidence of metastasis with ground-glass nodules (GGNs) has been reported, including pulmonary metastasis and distant metastasis. However, the clonal relationships of multiple GGNs at the genetic level remain unclear. Experimental design Sixty tissue specimens were obtained from 19 patients with multiple GGN lung cancer who underwent surgery in 2019. Whole exome sequencing (WES) was performed on tissue samples, and genomic profiling and clone evolution analysis were conducted to investigate the genetic characteristics and clonality of multiple GGNs. Results A total of 15,435 nonsynonymous mutations were identified by WES, and GGNs with shared nonsynonymous mutations were observed in seven patients. Copy number variant (CNV) analysis showed that GGNs in ten patients had at least one shared arm-level CNV. Mutational spectrum analysis showed that GGNs in three patients had similar six substitution profiles and GGNs in fou patients had similar 96 substitution profiles. According to the clone evolution analysis, we found that GGNs in five patients had shared clonal driver gene mutations. Taken together, we identified that 5 patients may have multiple primary GGNs without any similar genetic features, 2 patients may have intrapulmonary metastatic GGNs with ≥ 3 similar genetic features, and the other 12 patients cannot be determined due to insufficient evidences in our cohort. Conclusions Our findings suggest that the intrapulmonary metastasis exist in multiple GGNs, but the number of GGNs was not associated with the probability of metastasis. Application of genomic profiling may prove to be important to precise management of patients with multiple GGNs.

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Rapidly growing pulmonary ground-glass nodule caused by metastatic melanoma lacking uptake on 18F-FDG PET-CT

Cited by 6 publications

References 5 publications

Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

Two synchronous lung metastases from malignant melanoma: the same patient but different morphological patterns

Pulmonary metastases from malignant epithelioid schwannoma of the arm presenting as fast-growing subsolid nodules: Report of an unusual case

Utility of whole exome sequencing analysis in differentiating intrapulmonary metastatic multiple ground-glass nodules (GGNs) from multiple primary GGNs

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