High-resolution computed tomography findings of pulmonary tuberculosis in lung transplant recipients

Giacomelli, Irai Luis; Neto, Roberto Schuhmacher; Nin, Carlos S; Cassano, Priscilla de Souza; Pereira, Marisa; Moreira, José da Silva; Nascimento, Douglas Zaione; Hochhegger, Bruno

doi:10.1590/s1806-37562016000000306

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…Among the selected studies, the largest patient samples (78 and 35 patients, respectively) were in a study conducted in Brazil and a study conducted in South Korea, as can be seen in Table 1 . 26 , 29 , 31 , 32 …”

Section: Resultsmentioning

confidence: 99%

Chest X-ray and chest CT findings in patients diagnosed with pulmonary tuberculosis following solid organ transplantation: a systematic review

et al. 2018

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The objective of this systematic review was to select articles including chest X-ray or chest CT findings in patients who developed pulmonary tuberculosis following solid organ transplantation (lung, kidney, or liver). The following search terms were used: “tuberculosis”; “transplants”; “transplantation”; “mycobacterium”; and “lung”. The databases used in this review were PubMed and the Brazilian Biblioteca Virtual em Saúde (Virtual Health Library). We selected articles in English, Portuguese, or Spanish, regardless of the year of publication, that met the selection criteria in their title, abstract, or body of text. Articles with no data on chest CT or chest X-ray findings were excluded, as were those not related to solid organ transplantation or pulmonary tuberculosis. We selected 29 articles involving a collective total of 219 patients. The largest samples were in studies conducted in Brazil and South Korea (78 and 35 patients, respectively). The imaging findings were subdivided into five common patterns. The imaging findings varied depending on the transplanted organ in these patients. In liver and lung transplant recipients, the most common pattern was the classic one for pulmonary tuberculosis (cavitation and “tree-in-bud” nodules), which is similar to the findings for pulmonary tuberculosis in the general population. The proportion of cases showing a miliary pattern and lymph node enlargement, which is most similar to the pattern seen in patients coinfected with tuberculosis and HIV, was highest among the kidney transplant recipients. Further studies evaluating clinical data, such as immunosuppression regimens, are needed in order to improve understanding of the distribution of these imaging patterns in this population.

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Section: Resultsmentioning

confidence: 99%

Chest X-ray and chest CT findings in patients diagnosed with pulmonary tuberculosis following solid organ transplantation: a systematic review

et al. 2018

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“…In association with the clinical diagnosis, radiological diagnosis has been shown to be of great value, in which X-ray and/or Computed Tomography can demonstrate opacities and mainly cavitation characteristics suggestive of active pulmonary tuberculosis. It should be noted that in Brazil, approximately 26.7% of patients are treated without bacteriological confirmation of pulmonary tuberculosis, based only on the clinical radiological profile (Giacomelli et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil

Biadola¹,

Correa²,

Aguiar³

et al. 2020

RSD

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Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.

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Mycobacterium tuberculosis in Transplantation

Subramanian¹

2020

Emerging Transplant Infections

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High-resolution computed tomography findings of pulmonary tuberculosis in lung transplant recipients

Cited by 7 publications

References 18 publications

Chest X-ray and chest CT findings in patients diagnosed with pulmonary tuberculosis following solid organ transplantation: a systematic review

Chest X-ray and chest CT findings in patients diagnosed with pulmonary tuberculosis following solid organ transplantation: a systematic review

Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil

Mycobacterium tuberculosis in Transplantation

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