Growth, lung function, and physical activity in schoolchildren who were very-low-birth-weight preterm infants

Winck, Aline Dill; Heinzmann‐Filho, João Paulo; Schumann, Deise; Zatti, Helen; Mattiello, Rita; Jones, Marcus Herbert; Stein, Renato T.

doi:10.1590/s1806-37562015000000159

Cited by 8 publications

(8 citation statements)

References 39 publications

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“…Although most studies have shown a reduction in lung function in preterm infants, others have shown preserved lung function during childhood ( 17 , 18 ). Whether the diagnosis of BPD is a risk factor for later pulmonary morbidity has also been questioned ( 7 , 15 , 16 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants

Chang

Chi

et al. 2020

Front. Pediatr.

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Background: Survivors of preterm birth are at risk of long-term respiratory consequences. The objective of this prospective study was to assess pulmonary function at preschool age of former very low birth weight (VLBW) preterm children. Methods: Lung function of children born preterm and term controls aged 5–6 years were assessed by spirometry. The results were converted to z-scores. A questionnaire regarding respiratory symptoms was completed. Associations to gestational age (GA), birth weight (BW), bronchopulmonary dysplasia (BPD), and perinatal factors were assessed. Results: In total, 85 VLBW preterm children and 29 term controls were studied. Of the preterm children, the mean GA was 28.6 ± 2.6 weeks and the mean BW was 1,047 ± 273 gm. Preterm children had significantly lower z-scores of forced expiratory volume in 1 s (FEV 1 ), FEV 1 /forced vital capacity (FVC) ratio, and forced expiratory flow rate between 25–75% of FVC (FEF 25−75 ), compared with term controls (−0.73 vs. 0.04, p = 0.002; −0.22 vs. 0.39, p = 0.003; −0.93 vs. 0.0, p < 0.001; respectively). Further segregation of the preterm group revealed significantly impaired FEV 1 , FEF 25−75 in children at earlier gestation (≤ 28 weeks, n = 45), lighter at birth (≤ 1,000 g, n = 38), or with BPD ( n = 55) compared with term controls ( p < 0.05). There were significant negative relationships between the severity of BPD with FEV 1 , FVC, and FEF 25−75 ( p < 0.05). However, no correlation between lung function measurements and respiratory symptoms was found. Conclusions: VLBW preterm infants have reduced lung function at preschool age, especially among those with younger GA, lower BW, and BPD. Additional long-term follow-up of respiratory outcomes are needed for this vulnerable population.

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Section: Introductionmentioning

confidence: 99%

Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants

Chang

Chi

et al. 2020

Front. Pediatr.

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“…4 Others did not find any significant differences in lung function between VLBW infants and controls. 27 Unsurprisingly, most of the VLBW infants in our study were born premature and had a significantly higher rate of respiratory morbidities when compared to controls. Prior studies have shown that prematurity is a driving factor for the development of asthma, 9,10 bronchial hyperresponsiveness, 28 and childhood respiratory morbidities.…”

Section: Resultsmentioning

confidence: 66%

“…Pulmonary function abnormalities at school age described in VLBW infants were bronchial hyperreactivity, 25,26 airway obstruction, hyperinflation, and diffusion impairment 4 . Others did not find any significant differences in lung function between VLBW infants and controls 27 …”

Section: Discussionmentioning

confidence: 92%

Respiratory morbidity in very low birth weight infants through childhood and adolescence

Littner

Volinsky

Kuint

et al. 2021

Pediatric Pulmonology

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Objective: To describe the long-term (up to 18 years of age) respiratory outcomes of children and adolescents born at very low birth weight (VLBW; ≤1500 g) in comparison with that of children born >1500 g.Methods: An observational, longitudinal, retrospective study comparing VLBW infants with matched controls, registered at a large health maintenance organization in Israel. Pulmonary outcomes collected anonymously from the electronic medical files included respiratory illness diagnoses, purchased medications for respiratory problems, office visits with either a pediatric pulmonologist or cardiologist and composite respiratory morbidity combining all these parameters.Results: Our study included 5793 VLBW infants and 11,590 matched controls born between 1998 and 2012. The majority (99%) of VLBW infants were premature (born < 37 weeks' gestation), while 93% of controls were born at term. The composite respiratory morbidity was significantly higher in VLBW infants compared with controls in all age groups (relative risk [95% confidence interval]: 1 year: 1.22

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“…(7)(8)(9)(10) No entanto, poucos estudos analisaram a função pulmonar de indivíduos que foram prematuros moderados a tardios e apresentaram ou não doenças respiratórias neonatais. (11)(12)(13)(14) A oscilometria é um método não invasivo de avaliação da mecânica respiratória. (4,15) Em comparação com a espirometria, apresenta maior sensibilidade e especificidade na avaliação das vias aéreas periféricas.…”

Section: Introductionunclassified

“… 7 - 10 However, there have been few studies analyzing the lung function of individuals who had been moderately to late preterm infants and did or did not have neonatal respiratory diseases. 11 - 14 …”

Section: Introductionmentioning

confidence: 99%

Intra-breath oscillometry for the evaluation of lung function in children and adolescents with a history of preterm birth

et al. 2022

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Objective: To assess respiratory system impedance (Zrs) and spirometric parameters in children and adolescents with and without a history of preterm birth. Methods: We evaluated a sample of 51 subjects between 11 and 14 years of age: 35 who had a history of preterm birth (preterm group) and 16 who had been born at term (full-term group). Lung function was measured by spirometry, spectral oscillometry, and intra-breath oscillometry. Results: Neither spirometry nor spectral oscillometry revealed any statistically significant differences between the preterm and full-term groups. However, intra-breath oscillometry demonstrated significant differences between the two groups in terms of the change in resistance, reactance at end-inspiration, and the change in reactance (p < 0.05 for all). Conclusions: Our findings suggest that abnormalities in Zrs persist in children and adolescents with a history of preterm birth and that intra-breath oscillometry is more sensitive than is spectral oscillometry. Larger studies are needed in order to validate these findings and to explore the impact that birth weight and gestational age at birth have on Zrs later in life.

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Growth, lung function, and physical activity in schoolchildren who were very-low-birth-weight preterm infants

Cited by 8 publications

References 39 publications

Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants

Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants

Respiratory morbidity in very low birth weight infants through childhood and adolescence

Intra-breath oscillometry for the evaluation of lung function in children and adolescents with a history of preterm birth

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