BCGitis: A rare complication after intravesical BCG therapy

Oliveira, Maria João; Vaz, Daniel; Carvalho, Aurora; Braga, Rosana Teresinha Vaccare; Duarte, Raquel

doi:10.1590/s1806-37132015000000126

J. bras. pneumol.

2015

DOI: 10.1590/s1806-37132015000000126

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BCGitis: A rare complication after intravesical BCG therapy

Maria João Oliveira

Daniel Vaz

Aurora Carvalho

et al.

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Cited by 3 publications

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“…Intravesical administration of Bacillus Calmette-Guérin (BCG) is increasingly used as an adjunctive treatment for non-muscle invasive bladder cancer, as the treatment of choice [1]. Complications from this procedure may arise, and localized or disseminated BCG infection (BCGitis) has been reported, although being relatively rare [2] [3]. It is more common in patients with primary or secondary immunodepression.…”

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confidence: 99%

Genitourinary Bacillus Calmette-Guerin Infection after BCG Intravesical Administration in a Patient under Hemodialysis — What Can We Do Better?

Dias¹,

Almeida²,

Nogueira³

et al. 2022

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A 74-year-old man with terminal chronic kidney disease, under hemodialysis and with residual diuresis, was admitted due to myalgia, arthralgia, fever and pyuria in the previous 10 days. The patient had a recent diagnosis of high-grade non-invasive bladder cancer and was doing weekly BCG intravesical administrations. The symptoms started three days before the fifth administration. He had done cefixime as an outpatient and started piperacillin-tazobactam on hospital admission, but the fever persisted, and there was no bacterial isolation in urine or blood culture. On the tenth and seventeenth day after the last BCG intravesical administration Mycobacterium bovis was still isolated in the urine culture. The diagnosis of BCGitis was made and treatment was started, with a good response. Forty days after the last administration and under treatment, the culture remained positive for Mycobacterium bovis in the urine. We raise the question about the safety of BCG administration in patients with residual diuresis.

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mentioning

confidence: 99%

Genitourinary Bacillus Calmette-Guerin Infection after BCG Intravesical Administration in a Patient under Hemodialysis — What Can We Do Better?

Dias¹,

Almeida²,

Nogueira³

et al. 2022

AID

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Zur urogenitalen Klinik der lokalisierten/systemischen BCGitis

Böhm

Koch

Wenzel

et al. 2018

Urologe

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Adjuvant therapy with different bacillus Calmette-Guérin (BCG) preparations is a well-established guideline-endorsed treatment for nonmuscle invasive bladder cancer (NMIBC). Our observational study demonstrates equality between BCG and mitomycin C (MMC) treatment based on the oncological outcome. However, there were significant toxicity differences with higher rates in the BCG treatment group. The potential adverse effects of BCG in terms of a BCGitis are controversially discussed regarding their occurrence. As such, we sought to retrospectively evaluate the incidence in 106 consecutive patients. The BCG group demonstrated minor adverse effects in 78.4% and major adverse effects in 43.3%-partially coincident. Moreover, the parallel MMC group showed in 34.7% respectively 1.4% adverse events-as expected distinctly lower. In the context of this clinical discussion, we refer to alternative treatment concepts. Our data show a high clinical relevance of the patient's primary comorbidity.

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BCG

2016

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BCGitis: A rare complication after intravesical BCG therapy

Cited by 3 publications

References 3 publications

Genitourinary Bacillus Calmette-Guerin Infection after BCG Intravesical Administration in a Patient under Hemodialysis — What Can We Do Better?

Genitourinary Bacillus Calmette-Guerin Infection after BCG Intravesical Administration in a Patient under Hemodialysis — What Can We Do Better?

Zur urogenitalen Klinik der lokalisierten/systemischen BCGitis

BCG

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