Plasmodium falciparum malaria: another infection of interest to pulmonologists

Marchiori, Edson; Zanetti, Gláucia; Hochhegger, Bruno; Canella, Clarissa; Irion, Klaus

doi:10.1590/s1806-37132013000600015

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…10 Radiologic examinations may reveal features of noncardiogenic pulmonary edema and ARDS. 3,10,11 Bilateral pulmonary interstitial infiltrates are radiographic findings often described, 10,11 although consolidations, diffuse interstitial edema, and pleural effusion have also been seen on chest radiograph and CT imaging (Fig 2). 3,5,11…”

Section: Malariamentioning

confidence: 97%

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Pictorial Review of Thoracic Parasitic Diseases

Fiorentini

Bergo

Meirelles

et al. 2020

Chest

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Section: Malariamentioning

confidence: 97%

“…10 The identification of infected erythrocytes in blood smear analysis confirms the diagnosis. 10,11 When available, a rapid diagnostic test is also useful. The high lethality of severe malaria makes early diagnosis and treatment crucial.…”

Section: Malariamentioning

confidence: 99%

Pictorial Review of Thoracic Parasitic Diseases

Fiorentini

Bergo

Meirelles

et al. 2020

Chest

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Endemic Thoracic Infections in Latin America and the Caribbean

Restrepo¹,

Carrillo²,

Reyna³

et al. 2022

Radiologic Clinics of North America

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Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?

Pereira

Marinho

Epiphânio

2018

Front. Cell. Infect. Microbiol.

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Malaria is a serious disease and was responsible for 429,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications of severe malaria; it is characterized by a high mortality rate and can even occur after antimalarial treatment when parasitemia is not detected. Rodent models of ALI/ARDS show similar clinical signs as in humans when the rodents are infected with murine Plasmodium. In these models, it was shown that the induction of the enzyme heme oxygenase 1 (HO-1) is protective against severe malaria complications, including cerebral malaria and ALI/ARDS. Increased lung endothelial permeability and upregulation of VEGF and other pro-inflammatory cytokines were found to be associated with malaria-associated ALI/ARDS (MA-ALI/ARDS), and both were reduced after HO-1 induction. Additionally, mice were protected against MA-ALI/ARDS after treatment with carbon monoxide- releasing molecules or with carbon monoxide, which is also released by the HO-1 activity. However, high HO-1 levels in inflammatory cells were associated with the respiratory burst of neutrophils and with an intensification of inflammation during episodes of severe malaria in humans. Here, we review the main aspects of HO-1 in malaria and ALI/ARDS, presenting the dual role of HO-1 and possibilities for therapeutic intervention by modulating this important enzyme.

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Plasmodium falciparum malaria: another infection of interest to pulmonologists

Cited by 3 publications

References 7 publications

Pictorial Review of Thoracic Parasitic Diseases

Pictorial Review of Thoracic Parasitic Diseases

Endemic Thoracic Infections in Latin America and the Caribbean

Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?

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