Sobreposição de asma brônquica e DPOC

Alfaro, Tiago M.; Freitas, Sara da Silva; Cordeiro, Carlos Robalo

doi:10.1590/s1806-37132012000600021

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…( 9 ) Although studies have estimated that the worldwide prevalence of AR in adults is 10%, ( 22 ) in specific subgroups of patients, such as patients with COPD, the rate has yet to be determined. In the present study, 88 patients (59.1% of the sample) had AR symptoms triggered by allergens, a frequency that is much higher than the world average.…”

Section: Discussionmentioning

confidence: 99%

“…( 15 ) Paradoxically, a high frequency of eosinophilic bronchitis has been described in patients with stable COPD. ( 9 ) There is evidence of a subgroup of COPD patients who have a greater response to high doses of ICs, a positive bronchodilator response, frequent exacerbations, and an FEV 1 < 50% of the predicted value. However, it is necessary to establish the profile of these patients more accurately, reducing the side effects and costs related to the use of high doses of ICs in nonresponding patients.…”

Section: Introductionmentioning

confidence: 99%

“…( 17 , 18 ) There is evidence of eosinophilic bronchitis in up to 17% of patients with COPD, although the authors of that study did not conclude whether it was associated with a greater response to ICs. ( 9 ) There is an association between eosinophilia on NLC and asthma severity in adults, ( 19 ) but it is unclear whether this relationship occurs in COPD. This seems important since recent studies have described the overlap between COPD and asthma (overlap syndrome), ( 9 , 11 , 20 ) although this association has yet to be further investigated, as well as requiring a clinical and laboratory approach, in order to establish the profile of COPD patients with evidence of atopy.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of atopy in patients with COPD

Neves

Mendes

et al. 2013

J. bras. pneumol.

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OBJECTIVE: To determine the prevalence of atopy and to evaluate clinical, laboratory, and radiological profiles in patients with COPD. METHODS: This was a cross-sectional study involving outpatients with stable COPD (defined by the clinical history and a post-bronchodilator FEV1/FVC < 70% of the predicted value). The patients completed a questionnaire regarding clinical characteristics and atopy, after which they underwent nasal lavage cytology, skin prick testing, chest X-rays, arterial blood gas analyses, and determination of total serum IgE. RESULTS: Of the 149 subjects studied, 53 (35.6%), 49 (32.8%), and 88 (59.1%) presented with nasal eosinophilia, a positive skin prick test result, and symptoms of allergic rhinitis, respectively. Correspondence analysis confirmed these findings, showing two distinct patterns of disease expression: atopy in patients with COPD that was less severe; and no evidence of atopy in those with COPD that was more severe (reduced FEV1 and hyperinflation). There was a statistically significant association between nasal eosinophilia and a positive bronchodilator response. CONCLUSIONS: Using simple and reproducible methods, we were able to show that there is a high frequency of atopy in patients with COPD. Monitoring inflammation in the upper airways can be a useful tool for evaluating respiratory diseases in the elderly and in those with concomitant asthma and COPD, a clinical entity not yet fully understood.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of atopy in patients with COPD

Neves

Mendes

et al. 2013

J. bras. pneumol.

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Asthma and Chronic Obstructive Pulmonary Disease Overlap: The Effect of Definitions on Measures of Burden

Mannino¹,

Gan²,

Wurst³

et al. 2017

J COPD F

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Background: Although the overlap between asthma and COPD has been recognized for years this overlap has only recently been given a name, asthma-COPD overlap syndrome (ACOS), and better defined. Different definitions of the component diseases can affect prevalence and outcome measures of ACOS. Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) from [2007][2008][2009][2010][2011][2012] to determine the population estimates of ACOS in U.S. adults using 2 different definitions of ACOS (ACOS1 =self-reported COPD and current asthma; ACOS2 = spirometric-confirmed COPD [pre-bronchodilator FEV1/FVC <70%] and current asthma) and to describe variation in other factors, such as lung function impairment and health care utilization, by ACOS definitions. Results: Among U.S. adults aged 20 and older, 1.6% had ACOS1, and 1.9% had ACOS2. Both case definitions were similar with regard to symptoms and impairment of lung function. ACOS1 individuals were more likely to have one or more overnight hospital stays relative to those with neither asthma nor COPD, (odds ratio [OR] 3.4, 95% confidence interval [CI] 2.5, 4.6) than ACOS2 (OR 1.6, 95% CI 0.9, 2.9). Conclusions: Different definitions of ACOS in population-based studies affect both estimates of disease prevalence and outcomes related to the disease. These definitions need to be carefully considered in the design of epidemiologic studies and clinical trials. AbstractAbbreviations: asthma-COPD overlap syndrome, ACOS; National Health and Nutrition Examination Survey, NHANES; odds ratio, OR; confidence interval, CI; Global Initiative for Asthma, GINA; Global initiative for chronic Obstructive Lung Disease, GOLD; forced expiratory volume in 1 second, FEV 1 ; forced vital capacity, FVC; fractional exhaled nitric oxide, FeNO; parts per billion, ppb; body mass index, BMI; lower limit of normal, LLN Funding Support: This study was funded by GlaxoSmithKline (Study number WEUSKOP7057). Date of Acceptance: October 28, 2016 Citation: Mannino DM, Gan WQ, Wurst K, Davis KJ. Asthma and chronic obstructive pulmonary disease overlap: The effect of definitions on measures of burden.

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Sobreposição de asma brônquica e DPOC

Cited by 2 publications

References 15 publications

Evaluation of atopy in patients with COPD

Evaluation of atopy in patients with COPD

Asthma and Chronic Obstructive Pulmonary Disease Overlap: The Effect of Definitions on Measures of Burden

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