Osteíte por BCG Moreau em uma menina vacinada ao nascer

Morrone, Nelson; Antonio, Cláudio do Amaral; Santilli, C.; Costa‐Carvalho, Beatriz Tavares; Rodrigues, Denise

doi:10.1590/s1806-37132012000500019

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…[2] These complications include ulceration on the site of application, circular adenopathies, osteitis, and dissemination of the disease, which usually occurs in immunocompromised patients. [3] The appearance of the adverse effects depends on multiple factors such as dose, strain, method of application and the immunological status of the vaccinated individual. [4]…”

Section: Introductionmentioning

confidence: 99%

“…It usually has a unilateral condition, which suggests a local increase in the vasculature due to a probable traumatic antecedent in the area before the dissemination of the bacillus. [3] At the radiological level, it is characterized by presenting lytic lesions which predominate in the metaphyseal region of the long bones with the presence of periosteal reaction. With regard to the paraclinical tests, it usually shows low response of inflammatory markers, as opposed to the marked elevation of the same in “classic” cases of septic or osteomyelitis arthritis.…”

Section: Introductionmentioning

confidence: 99%

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Osteitis secondary to BCG vaccine in immunocompetent patients

Saldaña¹,

Ranero²,

Trujillo

et al. 2019

Medicine

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Rationale:Osteitis corresponds to a rare but potentially serious complication reported in pediatric population after the application of the Bacillus Calmette-Guerin (BCG) vaccine. In the present study, 3 clinical cases associated with this entity are reported.Patient concerns:The 1st case corresponds to a 1-year-old female patient who presented an increase in the volume of the right pelvic limb after BCG application. The second case is a 2-year-old male who began with an increase in volume, overactive gait and pain at the level of the left knee on walking that began after a trauma in the left low limb. The 3rd case corresponds to a 3-year-old patient who started with intense pain and limitation for ambulation.Diagnosis:Both the radiographical and histological studies presented data suggestive of infection by Mycobacterium tuberculosis complex, corroborated through biopsy and genotyping analysis with the isolation of Mycobacterium bovis as the causal agent.Interventions:The basic treatment scheme was based on Ethambutol, Rifampicin, Pyrazinamide, and Isoniazid. When M. bovis was typified, clarithromycin was added in the treatment.Outcomes:Osteitis secondary to BCG vaccine usually has a favorable evolution, especially in immunocompetent patients.Lessons:It was possible to confirm the association of BCG vaccine with the clinical picture of the patients who presented improvement after the start of antimicrobial management. Osteitis secondary to BCG vaccine usually presents a favorable evolution, especially in immunocompetent patients; however, the involvement of joint, growth discs and vertebrae increases the risk of presenting long-term sequels.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%