Variação diurna de parâmetros de função pulmonar e de força muscular respiratória em pacientes com DPOC

Fregonezi, Guilherme; Resqueti, Vanessa; Cury, Juliana L.; Paulin, Elaine; Brunetto, Antonio F.

doi:10.1590/s1806-37132012000200016

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…Rather, our data show there is an additional layer of circadian immune regulation within the lung at the level of cell number that must be taken into account if transcriptional profiling studies in the respiratory system are to be properly interpreted. When one considers the multiple pathways by which immune gene expression can achieve circadian variation in the lung it is easy to see why circadian influences are prominent in normal airway physiology 15 , in common inflammatory diseases of the airway 14, 43, 44 , and as we show here during systemic endotoxin. Although lung anatomy may impart unique aspects to circadian regulation in the respiratory system, alternative circadian programming as a general concept may be present in other contexts.…”

Section: Discussionmentioning

confidence: 89%

Circadian rhythm reprogramming during lung inflammation

et al. 2014

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Circadian rhythms are known to regulate immune responses in healthy animals, but it is unclear whether they persist during acute illnesses where clock gene expression is disrupted by systemic inflammation. Here, we use a genome-wide approach to investigate circadian gene and metabolite expression in the lungs of endotoxemic mice and find that novel cellular and molecular circadian rhythms are elicited in this setting. The endotoxin-specific circadian program exhibits unique features, including a divergent group of rhythmic genes and metabolites compared to the basal state and a distinct periodicity and phase distribution. At the cellular level endotoxin treatment also alters circadian rhythms of leukocyte counts within the lung in a bmal1-dependent manner, such that granulocytes rather than lymphocytes become the dominant oscillating cell type. Our results show that inflammation produces a complex reorganization of cellular and molecular circadian rhythms that are relevant to early events in lung injury.

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Section: Discussionmentioning

confidence: 89%

Circadian rhythm reprogramming during lung inflammation

et al. 2014

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“…When assessing the relationships between respiratory muscle strength and lung function, a positive correlation between MEP and MVV was observed, which represents the individual's ability to sustain a high level of ventilation 26 (i.e., the strength of the respiratory muscles) 34 . To sustain a high level of ventilation, it is important that the respiratory muscles maintain their strength, which highlights the relationship between these two components.…”

Section: Discussionmentioning

confidence: 99%

Lung function and six-minute walk test performance in individuals with sickle cell disease

Ohara¹,

Ruas²,

Walsh³

et al. 2014

Braz. J. Phys. Ther.

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BackgroundSickle Cell Disease (SCD), which is characterized by a mutation in the gene encoding beta hemoglobin, causes bodily dysfunctions such as impaired pulmonary function and reduced functional capacity. ObjectiveTo assess changes in pulmonary function and functional capacity in patients with SCD and to identify the relationships between these variables.MethodWe evaluated sociodemographic, anthropometric, lung function (spirometry), respiratory (manovacuometer), peripheral muscle strength (Handgrip strength - HS) and functional capacity (i.e., the six-minute walk test) parameters in 21 individuals with SCD (average age of 29±6 years). Shapiro-Wilk, paired Student's, Wilcoxon, Pearson and Spearman correlation tests were used for statistical analyses, and the significance threshold was set at p<0.05. ResultsA total of 47.6% of the study subjects exhibited an altered ventilation pattern, 42.8% had a restrictive ventilatory pattern (RVP) and 4.8% exhibited a mixed ventilatory pattern (MVP). The observed maximal inspiratory pressure (MIP) values were below the predicted values for women (64 cmH2O), and the maximum expiratory pressure (MEP) values, HS values and distance walked during the 6MWT were below the predicted values for both men (103 cmH2O, 39 Kgf and 447 m, respectively) and women (64 cmH2O; 27 Kgf; 405 m, respectively). Positive correlations were observed between maximum voluntary ventilation (MVV) and MEP (r=0.4; p=0.046); MVV and BMI (r=0.6; p=0.003); and between HS and MIP (r=0.7; p=0.001), MEP (r=0.6; p=0.002), MVV (r=0.5; p=0.015), distance walked in the 6MWT (r=0.4; p=0.038) and BMI (r=0.6; p=0.004). ConclusionsSCD promoted changes in lung function and functional capacity, including RVPs and a reduction in the distance walked in the 6MWT when compared to the predictions. In addition, significant correlations between the variables were observed.

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“…The date and time for each maneuver must be recorded. Diurnal variations of 3% in FEV 1 and 6% in PEF have been reported ( 116 ), with lower values noted in patients with COPD in the afternoon compared with the morning ( 117 ). In addition, the time data are useful for verifying pre- and post-bronchodilator maneuvers.…”

Section: Reported Valuesmentioning

confidence: 99%

Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement

Graham¹,

Steenbruggen²,

Miller³

et al. 2019

Am J Respir Crit Care Med

1,977

1,368

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Background: Spirometry is the most common pulmonary function test. It is widely used in the assessment of lung function to provide objective information used in the diagnosis of lung diseases and monitoring lung health. In 2005, the American Thoracic Society and the European Respiratory Society jointly adopted technical standards for conducting spirometry. Improvements in instrumentation and computational capabilities, together with new research studies and enhanced quality assurance approaches, have led to the need to update the 2005 technical standards for spirometry to take full advantage of current technical capabilities. Methods: This spirometry technical standards document was developed by an international joint task force, appointed by the American Thoracic Society and the European Respiratory Society, with expertise in conducting and analyzing pulmonary function tests, laboratory quality assurance, and developing international standards. A comprehensive review of published evidence was performed. A patient survey was developed to capture patients’ experiences. Results: Revisions to the 2005 technical standards for spirometry were made, including the addition of factors that were not previously considered. Evidence to support the revisions was cited when applicable. The experience and expertise of task force members were used to develop recommended best practices. Conclusions: Standards and consensus recommendations are presented for manufacturers, clinicians, operators, and researchers with the aims of increasing the accuracy, precision, and quality of spirometric measurements and improving the patient experience. A comprehensive guide to aid in the implementation of these standards was developed as an online supplement.

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Variação diurna de parâmetros de função pulmonar e de força muscular respiratória em pacientes com DPOC

Cited by 12 publications

References 27 publications

Circadian rhythm reprogramming during lung inflammation

Circadian rhythm reprogramming during lung inflammation

Lung function and six-minute walk test performance in individuals with sickle cell disease

Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement

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