Termoplastia brônquica em asma

Rubin, Adalberto Sperb; Cardoso, Paulo Francisco Guerreiro

doi:10.1590/s1806-37132010000400018

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The finding of hypertrophied smooth bronchial muscles in asthma patients justifies the use of this approach. The use of a probe by bronchoscopy that releases heat into the airway and leads to the destruction and/or atrophy of bronchial smooth muscle supports the biological plausibility for the use of this technique (113),(114). …”

Section: Introductionmentioning

confidence: 70%

Airway disease: similarities and differences between asthma, COPD and bronchiectasis

Athanazio¹

2012

Clinics

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Airway diseases are highly prevalent worldwide; however, the prevalence of these diseases is underestimated. Although these diseases present several common characteristics, they have different clinical outcomes. The differentiation between asthma, chronic obstructive pulmonary disease and bronchiectasis in the early stage of disease is extremely important for the adoption of appropriate therapeutic measures. However, because of the high prevalence of these diseases and the common pathophysiological pathways, some patients with different diseases may present with similar symptoms. The objective of this review is to highlight the similarities and differences between these diseases in terms of the risk factors, pathophysiology, symptoms, diagnosis and treatment.

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Section: Introductionmentioning

confidence: 70%

Airway disease: similarities and differences between asthma, COPD and bronchiectasis

Athanazio¹

2012

Clinics

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“…The similarity between OCT images and those produced evaluation of smoke-induced airway injury, (2) evaluation of anastomosis and small airways in lung transplantation, performance of endobronchial biopsies, (21) and measurement of tracheobronchial stenosis, (20) as well as evaluation of normal microanatomy and small airway and smooth muscle thickening in asthma patients, (22) COPD patients, (23) cystic fibrosis patients, and smokers, (24,25) together with pre-and post-bronchial thermoplasty evaluation. (26) In addition, OCT can aid in determining the size of the bronchi in the endoscopic treatment of emphysema with one-way valves. (27) In lung cancer, OCT has been used for differentiating normal mucosa from pre-neoplastic lesions.…”

Section: Discussionmentioning

confidence: 99%

Tomografia de coerência óptica broncoscópica

et al. 2012

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Objective: To evaluate the feasibility of and the potential for using optical coherence tomography in conjunction with conventional bronchoscopy in the evaluation of the airways. Methods: This was a pilot study based on an ex vivo experimental model involving three animals: one adult New Zealand rabbit and two Landrace pigs. An optical coherence tomography imaging catheter was inserted through the working channel of a flexible bronchoscope in order to reach the distal trachea of the animals. Images of the walls of the trachea were systematically taken along its entire length, from the distal to the proximal portion. Results: The imaging catheter was easily adapted to the working channel of the bronchoscope. High-resolution images of cross sections of the trachea were taken in real time, precisely delineating microstructures, such as the epithelium, submucosa, and cartilage, as well as the adventitia of the anterior and lateral tracheal walls. The corresponding layers of the epithelium, mucosa, and cartilage were clearly differentiated. The mucosa, submucosa, and trachealis muscle were clearly identified in the posterior wall. Conclusions: It is feasible to use an optical coherence tomography imaging catheter in combination with a flexible bronchoscope. Optical coherence tomography produces highresolution images that reveal the microanatomy of the trachea, including structures that are typically seen only on images produced by conventional histology.Keywords: Tomography, optical coherence; Trachea; Bronchoscopy; Microscopy; Diagnostic techniques, respiratory system. ResumoObjetivo: Avaliar a viabilidade e o potencial do uso da tomografia de coerência óptica em conjunto com um broncoscópio convencional na avaliação das vias aéreas. Métodos: Estudo piloto baseado em um modelo experimental ex vivo com três animais: um coelho adulto da raça Nova Zelândia e dois suínos da raça Landrace. Um cateter de imagem de tomografia de coerência óptica foi inserido no canal de trabalho de um broncoscópio flexível para alcançarmos a traqueia distal dos animais. As imagens foram obtidas sistematicamente em toda a traqueia ao longo das paredes, partindo da porção distal para a proximal. Resultados: O cateter de imagem se adaptou com facilidade ao canal de trabalho do broncoscópio. Imagens em alta resolução de cortes transversais da traqueia foram obtidas em tempo real, sendo delineadas microestruturas, tais como epitélio, submucosa, cartilagem e camada adventícia nas paredes anteriores e laterais da traqueia. As camadas correspondentes do epitélio, mucosa e cartilagens foram claramente diferenciadas. Na parede posterior, foi possível identificar mucosa, submucosa e musculatura traqueal. Conclusões: O uso de tomógrafo de coerência óptica em conjunto com um broncoscópio flexível é viável. A tomografia de coerência óptica produz imagens de alta resolução que permitem visualizar a microanatomia da traqueia, inclusive estruturas que normalmente são visualizadas somente na histologia convencional.Descritores: Tomografia de coerênc...

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Termoplastia brônquica em asma

Cited by 2 publications

References 21 publications

Airway disease: similarities and differences between asthma, COPD and bronchiectasis

Airway disease: similarities and differences between asthma, COPD and bronchiectasis

Tomografia de coerência óptica broncoscópica

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