Aspectos clínico-patológicos do carcinoma bronquioloalveolar e sobrevida em pacientes no estágio clínico I

Abstract

ResumoObjetivo: Analisar os aspectos clínico-patológicos do carcinoma bronquioloalveolar (CBA) e a sobrevida em uma amostra de pacientes com estadiamento clínico I. Métodos: Foram estudados retrospectivamente 26 pacientes com diagnóstico de CBA e estágio clínico I, , segundo a classificação tumor-node-metastasis (TNM, tumor-linfonodo-metástase), (15) AbstractObjective: To analyze the clinicopathological aspects of bronchioloalveolar carcinoma (BAC) and the survival in a sample of patients at clinical stage I. Methods: A retrospective study involving 26 patients diagnosed with clinical stage I BAC and undergoing surgery at the Thoracic Diseases Institute of the Federal University of Rio de Janeiro, in the city of Rio de Janeiro, Brazil, between 1987 and2007. We analyzed clinicopathological and radiological aspects, as well as mortality and survival. The data, which were collected from the medical charts of the patients, were statistically analyzed. Results: Females predominated (n = 16). The mean age at diagnosis was 68.5 years. Most patients were active smokers (69.2%). The most common forms of presentation of BAC were the asymptomatic form (84.6%) and the nodular form (88.5%). Involvement of the upper lobes predominated (57.7%). Stage IB was the most common pathological stage, followed by stages IA and IIB (46.2%, 38.4% and 15.4%, respectively). There was no in-hospital mortality. Four patients died during the postoperative follow-up, with a mean diseasefree survival time of 21.3 months. The overall five-year survival rate was 83%. The probability of survival for the patients diagnosed after 1999 showed a trend toward an increase when compared with that for those diagnosed up through 1999 (three-year survival rate: 92% vs. 68%; p = 0.07). Conclusions: The clinicopathological aspects of this study sample were similar to those of patients with BAC evaluated in previous studies.

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

“…Talc slurry is the agent most commonly used, and thoracoscopy is the technique of choice in Brazil. Brandao et al98 analyzed the clinical and pathological aspects of bronchiolo-alveolar carcinoma and the survival in a sample of patients at clinical stage I. Their data indicate these aspects were similar to those of patients with bronchiolo-alveolar carcinoma evaluated in previous studies.…”

Avaliação pré-operatória da força muscular respiratória, da função pulmonar e da capacidade funcional de pacientes submetidos a ressecção pulmonar

“…A cirurgia de ressecção pulmonar mais comum encontrada no estudo de Brandão et al 2 foi a lobectomia, assim como no presente estudo, sendo o tratamento cirúrgico sugerido em 53% dos pacientes da atual amostra.…”

Estudo comparativo do diagnóstico de câncer pulmonar entre tomografia computadorizada e broncoscopia

“…Bronchoscopy is thought to be fundamental in the diagnosis of lung cancer and also in the staging and follow-up of the disease (14,31,32) . This rating found in studies in the literature is corroborated by the results of the present study (sensitivity, 83.8%; specificity, 81.8%; accuracy, 82.8%).…”