Broncodilatação na DPOC: muito além do VEF1-efeito do salbutamol nas propriedades resistivas e reativas do sistema respiratório

Costa, Gil Vieira; Faria, Alvaro Camilo Dias; Mango, A; Lopes, Agnaldo José; Jansen, José Manoel; Melo, Pedro Lopes de

doi:10.1590/s1806-37132009000400006

Cited by 12 publications

(1 citation statement)

References 22 publications

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“…In a later study, 65 the effect of albuterol on respiratory resistance and reactance was evaluated in 70 patients divided into two groups based on spirometry findings: bronchodilator-negative (n=39) and bronchodilator-positive (n=31). It observed significantly smaller values in R 0 ( P <0.00002) and R m ( P <0.0002).…”

Section: Resultsmentioning

confidence: 99%

Brazilian studies on pulmonary function in COPD patients: what are the gaps?

Lopes

Melo

2016

COPD

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BackgroundCOPD is a major cause of death and morbidity worldwide, and is characterized by persistent airflow obstruction. The evaluation of obstruction is critically dependent on sensitive methods for lung-function testing. A wide body of knowledge has been accumulated in recent years showing that these methods have been significantly refined and seems promising for detection of early disease.ObjectivesThis review focuses on research on pulmonary function analysis in COPD performed in Brazil during this century.Materials and methodsThe literature was searched using a systematic search strategy limited to English language studies that were carried out in Brazil from the year 2000 onward, with study objectives that included a focus on lung function.ResultsAfter we applied our inclusion and exclusion criteria, 94 articles addressed our stated objectives. Among the new methods reviewed are the forced-oscillation technique and the nitrogen-washout test, which may provide information on small-airway abnormalities. Studies investigating the respiratory muscles and thoracoabdominal motion are also discussed, as well as studies on automatic clinical decision-support systems and complexity measurements. We also examined important gaps in the present knowledge and suggested future directions for the cited research fields.ConclusionThere is clear evidence that improvements in lung-function methods allowed us to obtain new pathophysiological information, contributing to improvement in our understanding of COPD. In addition, they may also assist in the diagnosis and prevention of COPD. Further investigations using prospective and longitudinal design may be of interest to elucidate the use of these new methods in the diagnosis and prevention of COPD.

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Section: Resultsmentioning

confidence: 99%