Papilomatose laringotraqueobrônquica: aspectos em tomografia computadorizada de tórax

Marchiori, Edson; Neto, César Augusto de Araújo; Meirelles, Gustavo de Souza Portes; Irion, Klaus; Zanetti, Gláucia; Missrie, Israel; Sato, Juliana

doi:10.1590/s1806-37132008001200016

Cited by 29 publications

(11 citation statements)

References 7 publications

(37 reference statements)

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“… 1 - 5 ) Although LTBP affects the larynx more commonly, the central airway can be involved in less than 5% of cases, and distal dissemination to the lung parenchyma occurs in about 1% of cases. 2 , 4 , 6 , 7 ) The disease has a higher incidence in children and is the most common benign laryngeal neoplasia in this age group. 4 , 6 - 9 ) It is assumed that the infection is more commonly acquired during birth, during the passage through the birth canal in mothers infected by the virus.…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 4 , 6 , 7 ) The disease has a higher incidence in children and is the most common benign laryngeal neoplasia in this age group. 4 , 6 - 9 ) It is assumed that the infection is more commonly acquired during birth, during the passage through the birth canal in mothers infected by the virus. Adults may also present LTBP, in whom the contamination by the virus is usually related to sexual contact.…”

Section: Introductionmentioning

confidence: 99%

“…Adults may also present LTBP, in whom the contamination by the virus is usually related to sexual contact. 1 , 3 , 4 , 10 , 11 ) Although a presumptive diagnosis can be made based on the history and clinical-radiological findings, the final diagnosis is made by histopathological analysis of the laryngeal or tracheal lesions, collected by bronchoscopy. 4 ) The course of the disease is unpredictable, ranging from spontaneous remission to aggressive disease with pulmonary dissemination and the need for multiple surgical procedures to maintain airway patency.…”

Section: Introductionmentioning

confidence: 99%

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Laryngotracheobronchial papillomatosis: chest CT findings

et al. 2017

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To evaluate the findings on chest CTs in 16 patients (8 men and 8 women) with laryngotracheobronchial papillomatosis. Methods:This was a retrospective study involving patients ranging from 2 to 72 years of age. The evaluation of the CT scans was independently performed by two observers, and discordant results were resolved by consensus. The inclusion criteria were presence of abnormalities on the CT scans, and the diagnosis was confirmed by anatomopathological examination of the papillomatous lesions. Results:The most common symptoms were hoarseness, cough, dyspnea, and recurrent respiratory infections. The major CT findings were nodular formations in the trachea, solid or cavitated nodules in the lung parenchyma, air trapping, masses, and consolidation. Nodular formations in the trachea were observed in 14 patients (87.5%). Only 2 patients had lesions in lung parenchyma without tracheal involvement. Only 1 patient had no pulmonary dissemination of the disease, showing airway involvement only. Solid and cavitated lung nodules were observed in 14 patients (87.5%) and 13 (81.2%), respectively. Masses were observed in 6 patients (37.5%); air trapping, in 3 (18.7%); consolidation in 3 (18.7%); and pleural effusion, in 1 (6.3%). Pulmonary involvement was bilateral in all cases. Conclusions:The most common tomography findings were nodular formations in the trachea, as well as solid or cavitated nodules and masses in the lung parenchyma. Malignant transformation of the lesions was observed in 5 cases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laryngotracheobronchial papillomatosis: chest CT findings

et al. 2017

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“…LP, caused by human papillomavirus, is characterized by the appearance of papillomas in the aerodigestive tract, with pulmonary involvement in ~ 1% of cases [1][2][3] . Infection commonly occurs at birth, by passing through the infected mother's birth canal [1][2][3] . The main clinical manifestations are hoarseness, cough, stridor, dyspnea, and recurrent infection.…”

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confidence: 99%

“…The main clinical manifestations are hoarseness, cough, stridor, dyspnea, and recurrent infection. The course of the disease is unpredictable, ranging from spontaneous remission to pulmonary dissemination requiring multiple surgical interventions, and malignant transformation to squamous cell carcinoma of the lung [1][2][3] . Although this diagnosis may be suggested by clinical and radiological findings, final diagnosis is made by histopathological analysis.…”

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Laryngotracheobronchial papillomatosis: an uncommon cause of recurrent respiratory infection

Ribeiro¹,

Marchiori

2020

Rev. Soc. Bras. Med. Trop.

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An updated review of the epidemiological factors associated with recurrent respiratory papillomatosis

Welschmeyer

Berke

2021

Laryngoscope Investig Oto

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Objectives To identify studies evaluating the epidemiology of recurrent respiratory papillomatosis (RRP), including patient demographics, human papillomavirus (HPV) immunology, clinical course, surgical and medical treatments, and psychosocial factors. Methods A systematic literature search through PubMed was performed to identify studies evaluating the epidemiological factors associated with RRP. All studies were screened through a priori selection criteria using the titles and abstracts. Results A total of 208 studies were identified, of which 54 met eligibility criteria and were included in the review. Conclusions RRP is a rare disease most commonly caused by HPV 6 and 11. It is characterized by recurring benign papillomatous lesions in the respiratory tract, particularly the larynx. Existing evidence about disease risk factors is limited but includes both maternal HPV infection and patient smoking and sexual behaviors. Disease management involves a combination of routine surgical and medical treatment. Surgical techniques include CO2‐laser, sharp dissection, coblation, microdebridement, and photoangiolytic laser. Medical treatments which have been found to facilitate disease control off‐label include interferon‐alpha (IFN‐α), indole‐3‐carbinol, acyclovir, bevacizumab, retinoids, and the Gardasil and mumps vaccines. Many patients suffer from additional psychosocial challenges related to their diagnosis. Current disease knowledge remains limited, and more robust controlled trials about risk factors, medical therapies, and surgical options are needed. Level of Evidence 5.

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Papilomatose laringotraqueobrônquica: aspectos em tomografia computadorizada de tórax

Abstract: In patients with laryngotracheobronchial papillomatosis, the most common tomographic finding was the combination of intratracheal polypoid lesions and multiple pulmonary nodules, many of which were cavitated.

Cited by 29 publications

References 7 publications

Laryngotracheobronchial papillomatosis: chest CT findings

Laryngotracheobronchial papillomatosis: chest CT findings

Laryngotracheobronchial papillomatosis: an uncommon cause of recurrent respiratory infection

An updated review of the epidemiological factors associated with recurrent respiratory papillomatosis

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