Impacto da umidificação aquecida com pressão positiva automática em vias aéreas na terapia do síndroma de apneia obstrutiva do sono

Salgado, Sara; Boléo-Tomé, José Pedro; Canhão, Cristina; Dias, Ana; Teixeira, Joana; Pinto, Paula; Caetano, Maria Cristina de Brito Eusébio Bárbara Prista

doi:10.1590/s1806-37132008000900009

Cited by 7 publications

(3 citation statements)

References 21 publications

(36 reference statements)

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“…On more detailed review by reading full texts, an additional 13 studies were excluded for the following reasons: not randomized design, inappropriate control group, not enough treatment duration and no outcomes of interested. Ultimately, only nine studies which satisfied the inclusion criteria were evaluated in this meta-analysis[16–19, 23, 25–28]. The detailed steps of the search are shown in (Fig 1).…”

Section: Resultsmentioning

confidence: 99%

“…A total of nine studies met our inclusion criteria. Five studies were parallel RCTs[17–19, 23, 28], while the rest were crossover studies[16, 25–27]. The duration of intervention ranged from 3 weeks to 12 months.…”

Section: Resultsmentioning

confidence: 99%

“…(6) Only English language studies were included. Specially, one of the eligible articles was found by us owing to its abstract published in English, but the full text was written in Portuguese[23]. We tried to translate the article into our language by using online translator, and it turned out that we were able to understand the content well.…”

Section: Methodsmentioning

confidence: 99%

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Heated humidification did not improve compliance of positive airway pressure and subjective daytime sleepiness in obstructive sleep apnea syndrome: A meta-analysis

Zhu

Cao

et al. 2018

PLoS ONE

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IntroductionWe performed a meta-analysis on whether heated humidification during positive airway pressure (PAP) could improve compliance and subjective daytime sleepiness in obstructive sleep apnea syndrome (OSAS) patients.Materials and methodsWe searched PubMed, EMBASE, Medline, Cochrane Library, Clinical Trials, Web of Science and Scopus from inception to Oct 29, 2017. We made meta-analysis on the all available randomized controlled trials (RCTs) which assessed effects of heated humidification intervention on PAP compliance and subjective daytime sleepiness, by subgroups of automatic adjusting positive airway pressure/ continuous positive airway pressure (APAP/CPAP) usage and patients with/without upper airway symptoms prior to PAP therapy.ResultsA total of nine RCTs were evaluated finally in this meta-analysis. When all the studies were pooled, heated humidification did not improve PAP usage time [weighted mean difference(WMD) = 13.28, 95% confidence interval(CI): -5.85 to 32.41, P = 0.17] or Epworth sleepiness scale (ESS) score (WMD = -0.63, 95% CI: -1.32 to 0.07, P = 0.08). In terms of PAP usage time, heated humidification failed to enhance compliance in both APAP (WMD = 22.34, 95%CI: -21.08 to 65.77, P = 0.31) or CPAP subgroup (WMD = 11.09, 95%CI: -10.21 to 32.40, P = 0.31) and it was also ineffective among patients with upper airway symptoms prior to PAP therapy (WMD = 22.74, 95% CI: -7.77 to 53.24, P = 0.14) or without (WMD = 13.22, 95%CI: -35.84 to 62.29, P = 0.60). In terms of ESS score, heated humidification did not reduce ESS scores in both APAP (WMD = -1.59, 95% CI: -3.81 to 0.64, P = 0.16) or CPAP subgroup (WMD = -0.39, 95% CI: -1.16 to 0.37, P = 0.32) and it was also helpless among patients with upper airway symptoms prior to PAP therapy (WMD = -1.17, 95% CI: -3.10 to 0.75, P = 0.23) or without (WMD = -0.30, 95%CI: -2.25 to 1.66, P = 0.76).ConclusionHeated humidification during PAP therapy improves neither the compliance nor ESS scores in OSAS patients, no matter what types of PAP or whether the patients had upper airway symptoms prior to PAP therapy. But to the population with upper airway symptoms and the APAP users, the conclusions were limited because of small sample size and possible selection bias. More attentions should be paid to these potentially possible benefited subgroups.

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