Amiloidose traqueobrônquica primária

Chatkin, Gustavo; Pipkin, Mauríco; Pinto, José Antônio; Silva, Vinícius Duval da; Chatkin, José Miguel

doi:10.1590/s1806-37132008000700013

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…11 Most of the red staining, the amyloid proteins display green birefringence under polarised light. 2,3,9,12 Due to the rarity of the condition, no randomised controlled trials have yet been conducted regarding nodular pulmonary amyloidosis management. However, the general consensus is that treatment depends on the severity of the symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…7,9 The classic radiological features of tracheobronchial amyloidosis are tracheal lumen irregularities, bronchial wall thickening and calcified amyloid deposition, which can be mural or endobronchial, resulting in subsegmental collapse. 5,7,12 Diffuse interstitial parenchymal amyloidosis is the rarest type of pulmonary amyloidosis and usually occurs among patients with systemic amyloidosis. 9 The deposited amyloid results in alveolar wall and capillary damage, leading to impaired gas exchange.…”

Section: Discussionmentioning

confidence: 99%

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Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature

Umairi

Al-Busaidi

2018

Sultan Qaboos Univ Med J

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Amyloidosis is a disorder characterised by the extracellular deposition of amyloid, a fibrillary protein, in various organs such as the lungs. Pulmonary nodular amyloidosis can mimic other lung conditions that present with pulmonary nodules, such as metastasis, sarcoidosis and hyalinising granuloma. We report a 60-year-old man who presented to the Royal Hospital, Muscat, Oman, in 2017 with a history of shortness of breath upon exertion, orthopnoea and bilateral lower limb swelling. A chest X-ray showed bilateral nodular opacities. Enhanced chest computed tomography revealed bilateral pulmonary nodules with a predominantly perilymphatic and subpleural distribution, giving the impression of a neoplastic nodule. A histopathological examination of biopsied lung tissue confirmed a diagnosis of nodular pulmonary amyloidosis.Keywords: Multiple Pulmonary Nodules; Amyloidosis; Computed Tomography; Case Report; Oman.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature

Umairi

Al-Busaidi

2018

Sultan Qaboos Univ Med J

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“…A miloidose é o termo utilizado para nomear a deposição extracelular de proteínas amiloides patológicas em um determinado sítio anatômico 1 . Essa doença pode ser subdividida em dois grandes grupos: localizada (apenas um órgão acometido) ou sistêmica (mais de um órgão acometido), sendo a forma sistêmica a mais comum 2 .…”

Section: Introductionunclassified

“…Dessa feita, destaca-se a raridade do acometimento pulmonar pela Amiloidose, a qual se classifica em quatro variantes, à depender do local e grau de acometimento, são elas: Amiloidose traqueobrônquica localizada ou difusa e Amiloidose parenquimatosa nodular ou difusa 2 . Essa doença transita desde um mero achado acidental, até um acometimento grave que pode cursar com óbito 3 .…”

Section: Introductionunclassified

Amiloidose pulmonar com apresentação traqueobrônquica: relato de caso clínico

Maso¹,

Dalbosco²,

Carneiro³

et al. 2022

Rev. Med. (São Paulo)

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Introdução: Amiloidose é o termo utilizado para designar doenças que fazem deposição extracelular de proteínas fibrilares patológicas em órgãos e tecidos, podendo ser sistêmica ou restrita a um único órgão. As manifestações clínicas são diversas, como cardiomiopatia, falência renal, esplenomegalia, problemas intestinais, neuropatias, problemas pulmonares, entre outros. Objetivo: relatar um caso clínico de paciente com amiloidose traqueobrônquica. Metodologia: revisão de bibliografias em comparação ao relato de caso, o qual foi descrito a partir de dados retirados do prontuário e de exames complementares da paciente. Caso clínico: paciente do sexo feminino, 70 anos, procurou assistência médica por dorsalgia, apresentando também chiado, tosse seca, dispneia paroxística noturna e ortopneia. Realizou-se investigação diagnóstica durante a internação, na qual biópsia da mucosa traqueobrônquica e coleta de lavado alveolar foram positivos para o teste Vermelho Congo, o que confirmou o diagnóstico de amiloidose. A paciente, então, foi encaminhada para terapia de ablação a laser. Conclusão: portanto, diante de um paciente com quadro clínico inspecífico e suspeita diagnóstica principal de amiloidose pulmonar, é imprescindível investigar e descartar diagnósticos diferenciais como neoplasia ou discrasia de células plasmáticas. Para isso, é necessário que haja alta precisão na análise dos exames de imagem, de modo a sugerir esse diagnóstico, o qual deve ser confirmado através da fibrobroncoscopia com biópsia de tecido brônquico, que através da coloração Vermelho do Congo, evidenciará presença de substância amorfa e birrefringente, compatível com substância amiloide.

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“…In China, only over 200 cases of TBA have been reported so far. The disease lacks typical clinical symptoms and imaging manifestations [ 3 ], so if clinicians do not have sufficient knowledge about TBA, misdiagnosis and missed diagnosis will be highly likely [ 4 ]. In recent years, with the popularization of bronchoscopy, the number of TBA cases diagnosed by bronchoscopy has significantly increased than before.…”

Section: Introductionmentioning

confidence: 99%

Bronchoscopic Diagnosis and Treatment of Primary Tracheobronchial Amyloidosis: A Retrospective Analysis from China

Wang

et al. 2017

BioMed Research International

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Objective. To assess the value of bronchoscopy in the diagnosis and treatment of primary tracheobronchial amyloidosis (TBA), in order to reduce misdiagnosis rates and improve prognosis. Methods. Clinical data of 107 patients with TBA reported from 1981 to 2015 in China were retrospectively analyzed for clinical features, bronchoscopic manifestations, pathologies, treatments, and outcomes. Results. 105 of 107 TBA patients were pathologically confirmed by bronchoscopy. Main bronchoscopic manifestations of TBA were single or multiple nodules and masses within tracheobronchial lumens; local or diffuse luminal stenosis and obstruction; luminal wall thickening and rigidity; rough or uneven inner luminal walls; congestion and edema of mucosa, which was friable and prone to bleeding upon touch; and so forth. 53 patients were treated with bronchoscopic interventions, like Nd-YAG laser, high-frequency electrotome cautery, freezing, resection, clamping, argon plasma coagulation (APC), microwaving, stent implantation, drug spraying, and other treatments. 51 patients improved, 1 patient worsened, and 1 died. Conclusion. Bronchoscopic biopsy is the primary means of diagnosing TBA. A variety of bronchoscopic interventions have good short-term effects on TBA. Bronchoscopy has important value in the diagnosis, severity assessment, treatment, efficacy evaluation, and prognosis of TBA.

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Amiloidose traqueobrônquica primária

Cited by 11 publications

References 11 publications

Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature

Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature

Amiloidose pulmonar com apresentação traqueobrônquica: relato de caso clínico

Bronchoscopic Diagnosis and Treatment of Primary Tracheobronchial Amyloidosis: A Retrospective Analysis from China

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