Acometimento pulmonar na doença de Behçet: uma boa experiência com o uso de imunossupressores

Santana, Alfredo Nicodemos Cruz; Antunes, Telma; Barros, Juliana Monteiro de; Kairalla, Ronaldo Adib; Carvalho, Carlos Roberto Ribeiro; Barbas, Carmen Sílvia Valente

doi:10.1590/s1806-37132008000600005

Cited by 9 publications

(5 citation statements)

References 13 publications

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“…In BD patients with PAI, the frequency of PH was reported to be 65% at initial evaluation in one study and 11% in another. Moreover, the presence of PH was found as a poor prognostic factor in patients with PAI [ 2 , 8 ]. In our study, overall PH frequency was 11%, whereas PH frequency was 40% in patients with PAI.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary hypertension in Behçet's disease: echocardiographic screening and multidisciplinary approach

ARMAĞAN¹,

OKŞUL²,

ŞENER³

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim Little is known about the prevalence and causes of pulmonary hypertension (PH) in Behçet’s disease (BD). This study was conducted to determine the prevalence and causes of PH in BD. Materials and methods In this descriptive study, we screened 154 patients with BD for PH using transthoracic echocardiography between February 2017 and October 2017. An estimated systolic pulmonary arterial pressure (sPAP ≥ 40 mmHg) was used as the cut-off value to define PH. Patients with BD were categorized into 5 groups according to organ involvement including mucocutaneous/articular, ocular, vascular, gastrointestinal, and neurologic involvement. Additional laboratory and imaging results were obtained from hospital file records to determine the causes of PH. Results PH was detected in 17 (11%) patients. Nine (52.9%) of these patients had group II PH (due to left heart disease), 4 (23.5%) had IV PH (due to pulmonary arterial involvement), and 1 had III PH (due to chronic obstructive lung disease). The frequency of PH was higher in BD patients with vascular involvement than those without (52.9% vs 28.5%; p = 0.04). Among 10 patients with pulmonary artery involvement (PAI) 4 (40%) had PH. Although the vascular BD group had the highest rate of PH, we observed no statistically significant difference in the frequency of PH between the predefined BD subgroups. Conclusions PH is not rare in patients with BD. The majority of BD patients with PH are in group II or IV PH. Patients with vascular involvement carry a higher risk for the development of PH. Monitoring BD patients with PAI should be considered for the development of group IV PH.

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Section: Discussionmentioning

confidence: 99%

“…However, these studies were conducted with a small number of patients or in selected patient groups. Causes of PH were incompletely defined in some [ 2 , 3 , 8 , 9 ]. The aim of this study is to determine the prevalence and causes of PH in a large series of BD.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary hypertension in Behçet's disease: echocardiographic screening and multidisciplinary approach

ARMAĞAN¹,

OKŞUL²,

ŞENER³

et al. 2023

Turkish Journal of Medical Sciences

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“…No estudo de Santana, et al 11 , foram identificados nove pacientes com acometimento pulmonar relacionado à SB. Os achados radiológicos foram aneurisma de artéria pulmonar (AAP) em oito pacientes, embolia pulmonar em três, hemorragia alveolar em um e hipertensão pulmonar em um de nove doentes.…”

Section: Discussionunclassified

Reabilitação fisioterapêutica na Síndrome de Behçet: revisão bibliográfica

et al. 2010

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ReSumo: A síndrome de Behçet (SB) é uma afecção inflamatória multissistêmica, de acometimento vascular e de causa ainda desconhecida, caracterizada por úlceras orais e genitais recorrentes, uveíte, lesões cutâneas, acometimento articular e neuromuscular. Este trabalho teve como propósito estudar a Síndrome de Behçet, os tratamentos médicos e propor as ferramentas de reabilitação fisioterapêutica nas alterações musculoesqueléticas e cutâneas. Trata-se de uma revisão da literatura. A pesquisa foi realizada em bases de dados, como Lilacs, Pubmed, Medline, e Scielo. Foram encontrados 65 artigos na íntegra, dos quais foram selecionados apenas 13, que apresentavam revisão da síndrome, tratamento, estudo de caso e manifestações clínicas. As ferramentas de reabilitações fisioterapêuticas, como eletrotermofototerapia, cinesioterapia, mecanoterapia, recursos terapêuticos manuais, termoterapia, crioterapia e hidroterapia, foram propostas com o objetivo de alívio da dor, anti-inflamatório, cicatrização das lesões cutâneas, efeito circulatório, diminuição de edema, aumento e manutenção da mobilidade articular, preservação e manutenção da força muscular e diminuição da rigidez, que podem intervir nos sintomas agudos e crônicos da SB. Autores relataram envolvimento de diversos sintomas na Síndrome de Behçet, como alterações musculoesqueléticas, cutâneas, mucocutâneas, neurológicas, gastrointestinais e cardiovasculares. Outros relataram os tratamentos medicamentosos à base de corticoides e imunossupressores. Alguns artigos especificaram a fisiopatologia da síndrome, diagnóstico, etiologia e dados atuais sobre as diferentes intervenções terapêuticas. Concluiu-se que, de acordo com as manifestações clínicas, o tratamento medicamentoso a partir da fisioterapia poderia trazer efeitos benéficos aos pacientes portadores dessa síndrome.PalavRaS-chave: Síndrome de Behçet. Reabilitação fisioterapêutica. Sindrome de Behçet -tratamento medicamentoso.aBStRact: Behçet syndrome (BS) is a multi-systemic inflammatory affection of vascular incidence and unknown cause, characterized by recurrent mouth and genital ulcers, uveitis, cutaneous injuries, articulation and neuromuscular incidence. This work aimed at studying Behçet Syndrome, medical treatments, as well as proposing tools for physiotherapeutic rehabilitation in musculoskeletal and cutaneous alterations. It is a literature survey involving searches in Lilacs, Pubmed, Medline and Scielo databases. 65 articles were found and 13 articles were selected that presented a review of the syndrome, treatment, case study and clinical manifestations. Tools for physiotherapeutic rehabilitation such as electro-thermal-phototherapy, therapeutic kinesiotherapy, mechanotherapy, hand resources , thermaltherapy, cryotherapy and hydrotherapy were proposed for alleviating pain, associated to anti-inflammatory drugs, healing cutaneous injuries, circulatory effect, edema reduction, increasing and maintaining mobility to articulate, preservation and maintenance of muscular force and reduction of rigidity, that ...

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“…Se ha descrito como una alteración multisistémica, caracterizada por lesiones genitales o en la mucosa oral, y uveítis. Puede haber compromiso pulmonar hasta en 5% de los casos; clínicamente se asocia con complicaciones tan severas como infarto pulmonar, aneurismas de arterias pulmonares y oclusión total de vasos pulmonares (25,39).…”

Section: Síndrome De Behçetunclassified

“…Este proceso vasculítico puede comprometer los vasos de cualquier tamaño, y llevar a las complicaciones mencionadas previamente. Ocurre hemorragia alveolar como resultado de un proceso infl amatorio agudo, que destruye las arterias pulmonares, por lo cual se considera que se manifi esta en los periodos de exacerbación de la enfermedad (39,40).…”

Section: Síndrome De Behçetunclassified

Enfoque inicial del paciente con hemorragia alveolar difusa asociada a vasculitis pulmonar

Guzmán

Caballero

Escobar

2011

rev. colomb. neumol.

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La hemorragia alveolar difusa es un síndrome clínico-patológico que se da como manifestación clínica de múltiples entidades patológicas. Debe considerarse siempre como una emergencia médica ya que puede comprometer de forma severa el funcionamiento adecuado del sistema respiratorio. Así mismo, es de vital importancia su reconocimiento y diagnóstico tempranos para iniciar su tratamiento agresivo y con ello evitar el deterioro de la función pulmonar.Aunque existen múltiples sistemas de clasifi cación de la hemorragia alveolar difusa, en cuanto a etiología e histopatología, resulta considerablemente útil clasifi carlas desde el punto de vista de diagnóstico y tratamiento en dos grandes grupos:1. Asociadas con fenómenos infl amatorios de la pequeña red capilar pulmonar (capilaritis).2. No asociadas a capilaritis. Con este artículo se pretende realizar una revisión de aquellas entidades asociadas a la hemorragia alveolar difusa y que pertenecen al grupo de las capilaritis.

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Acometimento pulmonar na doença de Behçet: uma boa experiência com o uso de imunossupressores

Cited by 9 publications

References 13 publications

Pulmonary hypertension in Behçet's disease: echocardiographic screening and multidisciplinary approach

Pulmonary hypertension in Behçet's disease: echocardiographic screening and multidisciplinary approach

Reabilitação fisioterapêutica na Síndrome de Behçet: revisão bibliográfica

Enfoque inicial del paciente con hemorragia alveolar difusa asociada a vasculitis pulmonar

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