Apresentação anatomopatológica das vasculites pulmonares

Capelozzi, Vera Luíza; Parras, Edwin Roger; Ab’Saber, Alexandre Muxfeldt

doi:10.1590/s1806-37132005000700005

J. bras. pneumol.

2005

DOI: 10.1590/s1806-37132005000700005

|View full text |Cite

Apresentação anatomopatológica das vasculites pulmonares

Vera Luíza Capelozzi

Edwin Roger Parras

Alexandre Muxfeldt Ab’Saber

Abstract: A apresentação anatomopatológica das vasculites pulmonares inclui um processo inflamatório da parede dos vasos pulmonares que pode vir acompanhado de granulomas, células gigantes, eosinófilos, necrose e hemorragia pulmonar. O conhecimento dessas manifestações, em associação com o tipo de vaso acometido e reações de imunofluorescência auxiliam no diagnóstico diferencial das vasculites.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2010

Publication Types

Select...

Article1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all of the cases, both pathologists made the diagnosis of WG in accordance with previously outlined criteria, and no areas of alveolar hemorrhage were encountered. (7,(10)(11)(12) In addition, four normal lung specimens, derived from autopsies of four individuals with fatal cranioencephalic trauma but without lung disease, were used as the control group. Tissue samples were embedded in paraffin, cut into 20-mm sections, deparaffinized, and heated in 10 mM citrate buffer (pH = 6.0) for 50 min in order to unmask antigens.…”

mentioning

confidence: 99%

Trombose em artérias pulmonares pequenas e médias em granulomatose de Wegener: um estudo com microscopia confocal por varredura a laser

et al. 2010

Self Cite

View full text Add to dashboard Cite

Objective: Wegener's granulomatosis (WG) can cause endothelial cell damage and thromboembolic events. Nevertheless, there have been few studies on the pulmonary microcirculation-small and medium-sized pulmonary arteries (SMSPA)-in patients with WG. The objective of this study was to quantify fibrin thrombi in the SMSPA of patients with WG. Methods: We analyzed 24 SMSPA samples collected from six patients with WG and 16 SMSPA samples collected from four patients without WG. In all samples, we used the endothelial cell marker CD34 and confocal laser scanning microscopy in order to detect intravascular fibrin thrombi. We calculated the total vessel area, the free lumen area, and the thrombotic area. Results: The mean total vessel area was similar in the WG and control groups (32,604 µm 2 vs. 32,970 µm 2 , p = 0.8793). Thrombi were present in 22 (91.67%) of the 24 WG group samples and in none of the control group samples (p < 0.0001; OR = 297; 95% CI: 13.34-6,612). The mean thrombotic area was greater in the WG group samples than in the control group samples (10,068 µm 2 vs. 0.000 µm 2 ; p < 0.0001). In contrast, the mean free lumen area was smaller in the WG group samples than in the control group samples (6,116 µm 2 vs. 24,707 µm 2 ; p < 0.0001). Conclusions: Confocal laser scanning microscopy revealed a significant association between pulmonary microvascular thrombosis and WG. This suggests a possible role of microvascular thrombosis in the pathophysiology of pulmonary WG, evoking the potential benefits of anticoagulation therapy in pulmonary WG. However, further studies are needed in order to confirm our findings, and randomized clinical trials should be conducted in order to test the role of anticoagulation therapy in the treatment of patients with pulmonary WG. Keywords:Vasculitis; Antibodies, antineutrophil cytoplasmic; Wegener granulomatosis; Thrombosis; Lung; Microscopy, confocal. ResumoObjetivo: A granulomatose de Wegener (GW) pode causar dano nas células endoteliais e fenômenos tromboembólicos. Entretanto, poucos estudos analisaram a microcirculação pulmonar -artérias pulmonares de pequeno/médio calibre (APPMC) -em pacientes com GW. O objetivo deste estudo foi quantificar trombos de fibrina em amostras de APPMC de pacientes com GW. Métodos: Analisamos 24 APPMC de seis pacientes com GW e 16 APPMC de quatro pacientes controles sem WG. Utilizamos CD34 para a marcação do endotélio em todas as amostras e microscopia confocal a laser para detectar trombos de fibrina intravasculares. Calculamos a área total do vaso, a área livre do lúmen e a área trombótica. Resultados: A média da área total do vaso foi similar no grupo GW e no grupo controle (32.604 µm 2 vs. 32.970 µm 2 , p = 0,8793). Trombos foram identificados em 22 das 24 APPMC (91,67%) no grupo GW, e em nenhuma do grupo controle (p < 0,0001; OR = 297 (IC95%: 13,. A média da área trombótica foi maior no grupo GW do que no grupo controle (10.068 µm 2 vs. 0.000 µm 2 , p < 0,0001). Em contraste, a média da área livre do lúmen foi menor no grupo GW que n...

show abstract

mentioning

confidence: 99%

Trombose em artérias pulmonares pequenas e médias em granulomatose de Wegener: um estudo com microscopia confocal por varredura a laser

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Apresentação anatomopatológica das vasculites pulmonares

Cited by 1 publication

References 10 publications

Trombose em artérias pulmonares pequenas e médias em granulomatose de Wegener: um estudo com microscopia confocal por varredura a laser

Trombose em artérias pulmonares pequenas e médias em granulomatose de Wegener: um estudo com microscopia confocal por varredura a laser

Contact Info

Product

Resources

About