Efeito comparativo entre a dipirona sódica e a dipirona sódica associada à cafeína no controle da dor pós-exodontia

Abstract

BACKGROUND AND OBJECTIVES: Adequate postoperative pain control is a challenge among surgical specialties, in spite of recent advances in analgesic techniques and analgesics. Caffeine has been used as therapeutic adjuvant to potentiate analgesic efficacy of some drugs, however there are still no scientific investigation reports on the association with sodium dipyrone in the postoperative period of dental procedures. So, this study aimed at observing and comparing the efficacy of sodium dipyrone alone or in association with caffeine to control postoperative pain of dental procedures, considering hemodynamic parameters of patients as indicators of anxiety and pain during surgery. METHODS: This is a crossover and double-blind study involving 50 young and healthy patients (25 males and 25 females) referred for bilateral extraction of impacted mandibular third molars. Operated side, patient's gender and analgesic drug used were randomized. Visual analog scale scores were submitted to Friedman test (α = 0.05) to compare pain intensity at defined intervals (preoperative, immediate postoperative, 1, 2, 4 and 12 hours, 1, 2, 3 and 7 days after surgery). Blood pressure and heart rate were measured in the preoperative period, after anesthetic injection and in the postoperative period (Friedman test, (α = 0.05). RESULTS: Patients have referred mild pain in the first two postoperative days and there has been no statistically significant difference between the analgesic efficacy of sodium dipyrone alone or in association with caffeine in different evaluated intervals. Most cardiovascular changes were within normality, considering anxiety and stress induced by surgery. CONCLUSION: The therapeutic protocol proposed in this Comparative effect of sodium dipyrone and sodium dipyrone associated to caffeine to control post-tooth extraction pain* Efeito comparativo entre a dipirona sódica e a dipirona sódica associada à cafeína no controle da dor pós-exodontia

Remoção cirúrgica de tórus palatino para reabilitação através de prótese parcial removível: relato de caso

“…No presente relato o analgésico de escolha foi a dipirona sódica de 1g devido a sua rápida ação no controle de dor de intensidade leve e moderada. (Vicentini et al 2013) explica que A dipirona sódica é um fármaco de grande utilização para o controle da sintomatologia dolorosa e inflamatória, sobretudo no pós-operatório de cirurgias odontológicas, com a sua efetividade analgésica podendo ser relacionada ao seu mecanismo de ação periférico, diferenciando a dos outros fármacos.…”

Alternativas de uso y Eficacia Analgésica en el Dolor de Origen Dental en un Servicio de Urgencias de Atención Primaria

“…A pesar de ello, la elección de los distintos tratamientos propuestos no se justifica sólo por el uso, sino que viene respaldada por numerosos trabajos: el Diclofenaco, uno de los AINES más representativos de su grupo, se ha usado extensamente en procesos odontológicos (Esteller-Martínez et al, 2004;Hersh et al, 2004;Joshi et al, 2004;Lopez Carriches et al, 2005); la Metilprednisolona, esteroide con potentes propiedades antiinflamatorias y pocas contraindicaciones, ha sido empleado también profusamente en estos procedimientos (Lopez Carriches et al;Ustün et al, 2003;Prieto et al, 2005;Tiwana et al, 2005;Markiewicz et al, 2008;Kim et al, 2009); y el Metamizol, derivado pirazolónico que actua sobre la síntesis de prostaglandinas, de igual forma (González Santana et al, 2005;Garcia Ramiro et al, 2013;Vicentini et al, 2013).…”