Avaliação do papel de opioides endógenos na analgesia do laser de baixa potência, 820 nm, em joelho de ratos Wistar

Meireles, Anamaria; Rocha, Bruno Pogorzelski; Rosa, Camila Thieime; Silva, Lígia Inez; Bonfleur, Maria Lúcia; Bertolini, Gladson Ricardo Flôr

doi:10.1590/s1806-00132012000200011

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…In addition to drug therapy, non-drug treatments for neuropathic pain such as surgery, acupuncture, transcutaneous electrical nerve stimulation, psychotherapy, and physiotherapy exist [2,[8][9][10][11][12][13]. Lowlevel laser therapy is one of the physiotherapy measures that can be taken for controlling neuropathic pain, and it has recently received much attention from researchers due to its low cost, being non-invasive and not having side effects [14,15]. Considering the anti-inflammatory property of laser [15,16], during inflammation, laser results in control of neuropathic pain via balancing chemical mediators, dilating arteries, increasing cortisol synthesis [15,17,18], and increasing the endorphin synthesis [19,20].…”

Section: Introductionmentioning

confidence: 99%

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

et al. 2019

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Background: Evidence has suggested that human adipose-derived stem cells (hADSCs) and low-level laser has neuroprotective effects on spinal cord injury (SCI). Therefore, the combined effect of the hADSCs and laser on neuregeneration and neuropathic pain after SCI was investigated. Methods: Forty-eight adult male Wistar rats with 200-250 g weight were used. Thirty minutes after compression, injury with laser was irritated, and 1 week following SCI, about 1 × 10 6 cells were transplanted into the spinal cord. Motor function and neuropathic pain were assessed weekly. Molecular and histological studies were done at the end of the fourth week. Results: The combined application of hADSCs and laser has significantly improved motor function recovery (p = 0.0001), hyperalgesia (p < 0.05), and allodynia (p < 0.05). GDNF mRNA expression was significantly increased in hADSCs and laser+hADSC-treated animals (p < 0.001). Finally, co-administration of hADSCs and laser has enhanced the number of axons around cavity more than other treatments (p < 0.001). Conclusions: The results showed that the combination of laser and ADSCs could significantly improve the motor function and alleviate SCI-induced allodynia and hyperalgesia. Therefore, using a combination of laser and hADSCs in future experimental and translational clinical studies is suggested.

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Section: Introductionmentioning

confidence: 99%

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

et al. 2019

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“…Segundo Meireles et al (2012), a redução da dor causada pelo laser pode vir de efeitos causados pela liberação periférica de opióides das células do sistema imunológico, com liberação de β-endorfina local.…”

Section: Discussionunclassified

“…De acordo com Meireles (2012), a liberação periférica de opióides das células do sistema imunológico, com liberação de β-endorfina local, é uma das possibilidades para o efeito analgésico do laser de baixa potência.…”

Section: Introductionunclassified

Influência Da Laserterapia Na Dor E Qualidade De Vida Em Mulheres Com Fibromialgia

et al. 2015

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“…LLLT and EA also could be applied in association, since both approaches support tissue repair [ 233 ] and decrease inflammation, edema and fibrinogen levels [ 243 , 244 , 245 ]. LLLT and EA both promote additional analgesia by increasing endorphins synthesis [ 243 , 246 ].…”

Section: How To Improve Pni Repair?mentioning

confidence: 99%

Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury—State of the Art

Gouveia,

Cardoso,

Carvalho

et al. 2024

Animals

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Traumatic nerve injuries are common lesions that affect several hundred thousand humans, as well as dogs and cats. The assessment of nerve regeneration through animal models may provide information for translational research and future therapeutic options that can be applied mutually in veterinary and human medicine, from a One Health perspective. This review offers a hands-on vision of the non-invasive and conservative approaches to peripheral nerve injury, focusing on the role of neurorehabilitation in nerve repair and regeneration. The peripheral nerve injury may lead to hypersensitivity, allodynia and hyperalgesia, with the possibility of joint contractures, decreasing functionality and impairing the quality of life. The question remains regarding how to improve nerve repair with surgical possibilities, but also considering electrical stimulation modalities by modulating sensory feedback, upregulation of BDNF, GFNF, TrKB and adenosine monophosphate, maintaining muscle mass and modulating fatigue. This could be improved by the positive synergetic effect of exercises and physical activity with locomotor training, and other physical modalities (low-level laser therapy, ultrasounds, pulsed electromagnetic fields, electroacupuncture and others). In addition, the use of cell-based therapies is an innovative treatment tool in this field. These strategies may help avoid situations of permanent monoplegic limbs that could lead to amputation.

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Avaliação do papel de opioides endógenos na analgesia do laser de baixa potência, 820 nm, em joelho de ratos Wistar

Cited by 12 publications

References 14 publications

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury

Influência Da Laserterapia Na Dor E Qualidade De Vida Em Mulheres Com Fibromialgia

Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury—State of the Art

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