Ação da fluoxetina sobre a dor aguda em ratos submetidos à constrição do nervo ciático

Abstract

BACKGROUND AND OBJECTIVES: Selective serotonin reuptake inhibitors, such as fluoxetine, have been suggested as alternative to tricyclic antidepressants to treat chronic pain, due to the lower incidence of side effects. This study aimed at observing the effects of serotonin on acute pain modulation, by the administration of fluoxetine through the formalin test in rats previously submitted to sciatic nerve constriction. METHOD: We used 24 male Wistar rats, with mean weight of 300 g and distributed in 5 groups: 1. Control untreated; 2. Sciatic nerve constriction; 3. Sciatic nerve constriction and treated with 5 mg.kg-1. day oral fluoxetine for 15 days; 4. Sciatic nerve constriction treated with 5 mg.kg-1 oral reserpine every 72 hours and with 5 mg.kg-1 .day oral fluoxetine for 15 days; 5. Sciatic nerve constriction treated with 5 mg.kg-1 oral reserpine every 72 hours for 15 days. All animals were submitted to modified formalin test after treatment. Fluoxetine action on acute pain in rats submitted to sciatic nerve constriction* Ação da fluoxetina sobre a dor aguda em ratos submetidos à constrição do nervo ciático

Estilo de vida, polifarmácia e interações medicamentosas em pacientes adultos/idosos com alteração de linguagem pós acidente vascular cerebral

“…A fluoxetina e o oxilato de escitalopram, agem inibindo seletivamente a recaptação da serotonina sem interferir em outros neurotransmissores, o que leva a menor incidência de efeitos colaterais, tornando-se antidepressivos mais utilizados no tratamento de alguns transtornos neurológicos (SALINAS et al, 2012, MANNING, 2004…”