Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: infecção pelo vírus linfotrópico de células T humanas (HTLV)

Rosadas, Carolina; Brites, Carlos; Arakaki-Sanchéz, Denise; Casseb, Jorge; Ishak, Ricardo

doi:10.1590/s1679-497420200006000015.esp1

Cited by 7 publications

(5 citation statements)

References 191 publications

(181 reference statements)

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“…The Department of Chronic Diseases and Sexually Transmitted Infections in the BMoH has a long history of collaboration with HTLV experts and patient representatives. This has been reinforced in recent years and has resulted in meaningful achievements, comprising HTLV awareness campaigns, training of healthcare professionals, production of technical material such as manuscripts on HTLV ( 21 , 22 ), the HTLV epidemiological bulletin ( 23 ) and the HTLV Clinical Guideline ( 19 ). HTLV experts and patient representatives also support the BMoH in identifying priorities for action and in closing gaps in the understanding of the burden of HTLV in the country.…”

Section: Resultsmentioning

confidence: 99%

Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of the Implementation of Public Health Policies on HTLV-1 in Brazil

et al. 2022

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Human T lymphotropic virus 1 (HTLV-1) is a public health issue for most countries and imposes important consequences on patients' health and socioeconomic status. Brazil is one of the global leaders of the public health response to these viruses. The country has challenges to overcome to implement meaningful policies aiming to eliminate HTLV-1/2. An analysis of strengths, weaknesses, opportunities, and threats (SWOT) for the implementation of public health policies on HTLV-1/2 was performed. The strengths identified were the Brazilian Unified Health System (SUS); Brazilian expertise in public health programs successfully implemented; currently available policies targeting HTLV; and strong collaboration with researchers and patient's representative. Lack of awareness about HTLV, insufficient epidemiological data, lack of reference centers for patient care, insufficient availability of confirmatory tests, lack of universal antenatal screening, and absence of cost-effectiveness studies were identified as weaknesses. Some interesting opportunities included the increased interest from international organizations on HTLV, possibility of integrating HTLV into other programs, external funding for research, available online platforms, opportunity to acquire data from HTLV-1/2 surveillance to gather epidemiological information, and HTLV policies that were implemented independently by states and municipalities. In addition to the COVID-19 pandemic, existing demands from different diseases, the country's demography and its marked sociocultural diversity and the volatility of the technical team working with HTLV-1/2 at the Brazilian Ministry of Health are threats to the implementation of public policies on HTLV-1/2. This SWOT analysis will facilitate strategic planning to allow continuous progress of the Brazilian response to HTLV-1/2 infection.

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Section: Resultsmentioning

confidence: 99%

Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of the Implementation of Public Health Policies on HTLV-1 in Brazil

et al. 2022

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“…Contudo, observam-se a maior preponderância e ocorrência no Brasil, por volta de 5,3 por 1000 casos são soropositivos por ano (Takatani et al, 2017, Silva, 2018. O predomínio em gestantes, corresponde a aproximadamente 1% à 1,05% no país, os mais atingidos de cada região -pelos dados mais recentes utilizados pelo autor-são o Pará com 324 casos, Maranhão com 713, Mato Grosso do Sul com 116.689 casos, Rio de Janeiro com 1.628 e Paraná com 643 (Rosadas et al, 2021;Puccioni-Sohler et al, 2019).…”

Section: Resultsunclassified

“…Precaver a incidência é o mais adequado meios de combate logo não contêm vacinas ou tratamento. As recomendações consistem em diminuir a incidência pela via vertical, substituir a lactação por fórmulas lácteas, realizar uma triagem no pré-natal, que não são utilizadas pelo Sistema Único de Saúde (SUS), a receptividade de mães e familiares infectados e a implantação de medidas de prevenção (Rosadas et al, 2021, Zihlmann, Mazzaia, Alvarenga, 2017De Fatima et al, 2020).…”

Section: Resultsunclassified

Soroprevalência de HTLV em gestantes: revisão integrativa

Mendes¹,

Pacheco²,

Silva³

et al. 2021

RSD

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Introdução: Especula-se que cerca de 10 a 20 milhões de indivíduos contaminados pelo HTLV no mundo. O Brasil atinge as primeiras posições do ranking. Os meios de propagação do vírus ocorrem por aleitamento materno, por transmissão vertical, sexual e parenteral. O marcador para identificar o alto risco de TMI, são as PVL de HLTV-1 em células mononucleares no sangue periférico da gestante. Objetivo: averiguar a soroprevalência de HTLV nas gestantes, efetivando uma revisão integrativa do assunto em questão e analisar as formas preventivas para a progênie do hospedeiro. Metodologia: Refere-se a uma revisão integrativa utilizando bancos de dados online como: Google School, BIREME, SCIELO, PUBMED, FIOCRUZ, MS, USP, LILACS, Science Direct. Resultado e Discussões: Com a complexidade de diagnósticos de casos leves, localizadas no plasma e a escassez de testes confirmatórios deste, pela detecção do anti-HTLV por PCR, ELISA ou Western Blot, acarreta complicações para diagnostico de ATLL em adultos de 20 a 30 anos, que ocorre posteriormente à infecção na criança. O aleitamento materno torna-se a principal via de transmissão, superando os casos relatados por via sexual e parenteral. Contudo, como a investigação sobre transmissão, não é empregue no Brasil, seja por via sexual ou TMI, ocasiona endemia recorrente no país. Tornando a prevenção da incidência o meio mais adequado ao combate logo não contêm vacinas ou tratamento. Conclusão: O SUS carece no aprimoramento das pesquisas epidemiológicas para averiguar a endemicidade e proporcionar o rastreamento e auxilio as gestantes soropositivas.

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“…In addition to an accurate laboratory diagnosis that allows identifying the prevalence of infection in a given geographic area, it is necessary to implement a counseling and follow-up service for PLHTLV to provide efficient clinical, laboratory and psychological monitoring. Rosadas et al ( 34 ) emphasize the importance of including the multiprofessional screening of HTLV in the routine care provided in services for people infected with HIV and other STIs. For this reason, all individuals diagnosed in our study were referred to initial counseling with a nurse, at which time they were informed about HTLV, its modes of transmission and prevention, associated diseases and supportive therapies for infection-related symptoms.…”

Section: Discussionmentioning

confidence: 99%

The Relevance of a Diagnostic and Counseling Service for People Living With HTLV-1/2 in a Metropolis of the Brazilian Amazon

Lopes

Sousa

Gomes

et al. 2022

Front. Public Health

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IntroductionTo identify the prevalence of infection in the urban area of the capital city of Belém, Brazil, the Laboratory of Virology of the Federal University of Pará implemented, as a public service, serological screening for human T-lymphotropic viruses 1 and 2 (HTLV-1/2) infection and, if necessary, counseling service and referral to specialized medical care. The project is funded by the National Council of Science and Technology, the Ministry of Health of Brazil and the Pan American Health Organization.MethodsFrom January 2020 to June 2021, 1,572 individuals of both sexes were approached to answer a questionnaire and were tested using an enzyme immunoassay (Murex HTLV-I+II, DiaSorin, Dartford, UK). Seropositive samples were confirmed as HTLV-1 and HTLV-2 infection by line immunoassay (INNO-LIA® HTLV I/II Score, Fujirebio, Japan) and/or by real-time polymerase chain reaction. G and Fisher's exact tests were applied to identify the association between epidemiological characteristics and HTLV-1/2 infection.ResultsOf the 1,572 screened individuals, 63.74% were females between the ages of 30 and 59 years (49.04%). Infection was confirmed in six individuals (0.38%), among whom three (0.19%) were infected with HTLV-1 and three with HTLV-2 (0.19%). Blood transfusion before 1993 was the main risk factor associated with the route of exposure to the virus (p = 0.0442). The infected individuals were referred to a counseling session with a nursing professional, and two patients who manifested signs and symptoms suggestive of myelopathy associated with HTLV were referred to a neurologist.ConclusionThe implementation of the screening service revealed the occurrence of moderate endemicity of HTLV-1/2 in Belém, reinforcing the importance of continuing the service as a means of establishing an early diagnosis and providing counseling as a measure to prevent and control viral transmission in the general population.

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Protocolo Brasileiro para Infecções Sexualmente Transmissíveis 2020: infecção pelo vírus linfotrópico de células T humanas (HTLV)

Cited by 7 publications

References 191 publications

Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of the Implementation of Public Health Policies on HTLV-1 in Brazil

Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of the Implementation of Public Health Policies on HTLV-1 in Brazil

Soroprevalência de HTLV em gestantes: revisão integrativa

The Relevance of a Diagnostic and Counseling Service for People Living With HTLV-1/2 in a Metropolis of the Brazilian Amazon

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