Influence of growth hormone replacement on neurological and psychomotor development. Case report

Abstract

The height response to the use of growth hormone in short height cases has already been confirmed in the literature. The influence of the insulin-like growth factor 1 (GH-IGF1) axis components on development, function, regeneration, neuroprotection, cognition, and motor functions has been evaluated in experimental studies and in adults with central nervous system lesions. However, there is still little research on the clinical impact of hormone replacement on neurological and psychomotor development. This report presents the case of a patient with excellent weight-height recovery and, even more surprisingly, neurological and psychomotor development in response to use of growth hormone. The result strengthens the correlation between experimental and clinical findings related to cerebral plasticity response to growth hormone in children. A preterm male patient with multiple health problems during the neonatal and young infancy period, who for six years presented with a relevant deficit in growth, bone maturation, and neurological and psychomotor development. At six years of age, he had low stature (z-score −6.89), low growth rate, and low weight (z-score −7.91). He was incapable of sustaining his axial weight, had not developed fine motor skills or sphincter control, and presented with dysfunctional swallowing and language. Supplementary tests showed low IGF-11 levels, with no changes on the image of the hypothalamus-pituitary region, and bone age consistent with three-year-old children — for a chronological age of six years and one month. Growth hormone replacement therapy had a strong impact on the weight-height recovery as well as on the neurological and psychomotor development of this child.

Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP and Growth and Development in Children with Short Stature Based on Big Data Analysis

“…In this study, the laboratory tests were used to analyze the differences of growth and development indices, gastrin, serum IGF-1, and GHBP between children with SS and healthy children by big data, hoping to determine the correlation between the levels of gastrin, serum IGF-1, and GHBP and growth and development in children with SS by comparing the clinical data. The result showed that the levels of gastrin, serum IGF-1, and GHBP of children in the study group were significantly lower than those in the control group (P < 0:05), and the result enabled people to have a new understanding of SS, which was obviously better than that of Motta Felipe et al [25]. The Pearson…”