Is Zika virus outbreak a solved issue in Brazil?

Avelino‐Silva, Vivian Iida

doi:10.1590/s1679-45082018ed4325

Cited by 3 publications

(6 citation statements)

References 28 publications

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“…This general situation is aggravated by the region’s characteristic drought, forcing peripheral populations, without the State’s assistance, to store water. Although the ZIKV epidemic has calmed down in 2017, the transmission still persists 35 and the levels of Ae. aegypti infestation remain high.…”

Section: Discussionmentioning

confidence: 99%

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Personal protective measures of pregnant women against Zika virus infection

Melo

Corte

2019

Rev. saúde pública

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OBJECTIVE: To evaluate the adherence of pregnant women to personal protective measures against mosquito bites, recommended by the Ministry of Health, and to investigate the factors associated with the non-adoption of these measures. METHODS: We interviewed 177 pregnant women between November 2016 and February 2017 in the 10 basic health units of the municipality of Propriá, state of Sergipe, two located in the rural area and eight in the urban area, during prenatal appointments, to raise information about the use of preventive measures against the vector transmission of Zika virus. Data were analyzed using descriptive statistical methods, chi-square test or Fisher’s exact test, and the odds ratio was calculated. The independent variables were grouped by the analysis of principal components, and the dependents (the use of repellent, mosquito nets, garments, screens and insecticides) were analyzed using the logistic regression method. RESULTS: Among the measures recommended by the Ministry of Health, mosquito nets were the most used by pregnant women living in rural areas and with low education level, while the repellents were more used by women in the urban area and with higher education level. Women in a vulnerable socio-economic situation presented a risk 2.4 times higher for not using screens in their homes, 1.9 times higher for not changing clothes and 2.5 times higher for not using repellent than pregnant women in better economic conditions. CONCLUSIONS: The socioeconomic status of pregnant women, especially among the less privileged, influenced the use of protective measures against Zika virus, from the purchase of repellent, clothing, insecticides to other resources in the municipality of Propriá, SE.

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Section: Discussionmentioning

confidence: 99%

“…Essa situação geral é agravada pela seca caracteristica da região, obrigando as populações periféricas, sem assistência do Estado, a armazenar água. Embora a epidemia de ZIKV tenha arrefecido em 2017, a transmissão ainda persiste 35 e os níveis de infestação por Ae. aegypti continuam elevados.…”

Section: Discussionunclassified

Personal protective measures of pregnant women against Zika virus infection

Melo

Corte

2019

Rev. saúde pública

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“…For instance, in Z. tritici, strains without target site alterations in the SdhB, C, or D genes were resistant by an efflux pump mechanism and had a 519-bp insert in the MgMFS1 promoter [77]. In our study, out of the 63 Mm and Mf isolates with resistance to SDHI, approximately 77% (N = 49) were also insensitive to the DMIs propiconazole and tebuconazole ( [47,55] and Personal communication, 2023 [65]. A total of 18.5% of the isolates sampled from these pathogens' populations were also resistant to QoI fungicides [7].…”

Section: Discussionmentioning

confidence: 55%

“…Most studies on resistance mechanisms to SDHI fungicide in plant pathogens have found target site alterations as the main underlying cause [45]. Examples of plant pathogens where Sdh mutations have been reported both in field isolates and in lab mutants are A. alternata (SdhB-H277Y/R, SdhC-H134R, SdhD-D123E, SdhD-H133R), B. cinerea (SdhB-P225L/T/F, SdhB-H272Y/R/L/V, SdhB-N230I, SdhD-H132R), P. teres (SdhB-H277Y, SdhC-N75S, SdhC-G79R, SdhC-H134R, SdhC-S135R, SdhD-D124N/E, SdhD-H134R, SdhD-D145G), and Z. tritici (SdhB-N225T, SdhB-R265P, SdhB-T268I, SdhC-T79N/I, SdhC-W80S, SdhC-S83G, SdhC-A84F/I, SdhC-L85P, SdhC-N86A/S, SdhC-R87C, SdhC-V88D, SdhC-H145R, SdhC-R151M/R/S/T, SdhC H152R) [33,41,52,65,[70][71][72][73][74].…”

Section: Discussionmentioning

confidence: 99%

“…Three Mf and Mm isolates with different and multiple resistance (i.e., multidrug resistance (MDR) phenotypes) to QoI, DMI, and/or SDHI fungicides, according to previous ( [7,55,59] and Personal communications, 2023 [65] and current studies, were selected and retested for this assay, giving the following phenotypes: Mf Ja2.24 (QoI R (resistant), DMI MR (moderately resistant), and SDHI ER (extremely resistant)), Mf Ja3.6 (QoI S (sensitive), DMI S to MR depending on DMI tested, SDHI ER), and Mf Ja3.9a (QoI S, DMI MR, SDHI ER); Mm Ja1.38c (QoI S, DMI ND, and SDHI MR/HR), Mm MG4 (QoI S, DMI RS, and SDHI RS/MR), Mm MG47 (QoI S, DMI RS (with reduced sensitivity)/MR, and SDHI ER). Two Mm isolates with different and multiple sensitivity phenotypes were included in the assay for comparison, as follows: Mm ISC92 (QoI S, DMI RS, and SDHI S), and Mm ISR61 (QoI S, DMI ND (not determined), and SDHI ER).…”

Section: Sensitivity To Efflux Pump Substratesmentioning

confidence: 99%

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Resistance to Site-Specific Succinate Dehydrogenase Inhibitor Fungicides Is Pervasive in Populations of Black and Yellow Sigatoka Pathogens in Banana Plantations from Southeastern Brazil

Silva,

Moreira,

de Souza

et al. 2024

Agronomy

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The Sigatoka disease complex (SDC), caused by Mycosphaerella fijiensis (Mf) and M. musicola (Mm), comprises the most destructive fungal leaf streak and spot diseases of commercial banana crops worldwide. In Brazil, the site-specific succinate dehydrogenase inhibitor (SDHI) fungicides labeled for SDC management since 2014 present a high risk for the emergence of resistance if deployed intensively and solo. Our study determined the levels of sensitivity to boscalid and fluxapyroxad in four populations of the SDC pathogens sampled in 2020 from three distinct geographical regions under contrasting fungicide programs. Resistance, defined as EC50 values exceeding 20 µg mL−1, was prevalent at 59.7% for fluxapyroxad and 94.0% for boscalid. Only 1.5% of isolates exhibited sensitivity to both fungicides. We also assessed the changes in the corresponding fungicide target protein-encoding genes (SdhB, C, and D). None of the target site alterations detected were associated with reduced sensitivity. A second SdhC paralog was also analyzed, but target alterations were not found. However, MDR (multidrug resistance) was detected in a selection of isolates. Further monitoring for Sdh target mutations will be important, but an important role for other resistance mechanisms such as the presence of additional Sdh paralogs and MDR cannot be ruled out. These results highlight the importance of implementing sound anti-resistance management strategies when SDHI fungicides are deployed for the management of SDC.

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Colaboração científica brasileira em Emergências de Saúde Pública de Importância Internacional

Roberto Cintra

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Escrever uma tese, intrinsecamente, não é tarefa fácil. Escrever uma tese, durante a ocorrência de uma pandemia e cuja temática a envolve, torna esse trabalho ainda mais laborioso. Novas informações e achados científicos continuam sendo descobertos a cada dia. No caso da Covid-19, essa característica é ainda mais patente. Não obstante, algumas pessoas contribuíram para que essa jornada se tornasse mais leve, possibilitando um melhor desenvolvimento, meu e do texto. A elas, deixo aqui meus sinceros agradecimentos: À minha orientadora, Prof.ª Dr.ª Janaina Pamplona da Costa, pela paciência, dedicação e tempo despendido nas leituras; pelas correções, discussões e trocas de ideias que permitiram a realização desta tese; pela disposição em sempre me ajudar; e pelos ensinamentos a respeito das várias facetas da pesquisa científica.

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Is Zika virus outbreak a solved issue in Brazil?

Cited by 3 publications

References 28 publications

Personal protective measures of pregnant women against Zika virus infection

Personal protective measures of pregnant women against Zika virus infection

Resistance to Site-Specific Succinate Dehydrogenase Inhibitor Fungicides Is Pervasive in Populations of Black and Yellow Sigatoka Pathogens in Banana Plantations from Southeastern Brazil

Colaboração científica brasileira em Emergências de Saúde Pública de Importância Internacional

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