2015
DOI: 10.1590/s1679-45082015ao3477
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Abstract: Objective To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression.Methods Tissue samples from neoplastic and non-neoplastic colorectal tissues were obtained from 64 operated patients who had colorectal carcinoma with no distant metastases. Expressions of heparan sulphate, chondroitin sulphate, dermatan sulphate and their fragments were analyzed by elec… Show more

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Cited by 12 publications
(8 citation statements)
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“…However, it is possible that the enzyme is also responsible for the appearance of special structures in CS/DS that promote the progression of a tumor as hypothesized in the case of hepatocellular carcinoma . The remodeling of the GAG profile in the majority of, if not in all, tumors is manifested as a substantially increased content of CS in the tissues . In turn, the level of DS in a tissue depends on the type of tumor and is mostly reduced.…”
Section: The Metabolism Of Cs/ds Is Strongly Altered In the Tumor Stromamentioning
confidence: 99%
See 1 more Smart Citation
“…However, it is possible that the enzyme is also responsible for the appearance of special structures in CS/DS that promote the progression of a tumor as hypothesized in the case of hepatocellular carcinoma . The remodeling of the GAG profile in the majority of, if not in all, tumors is manifested as a substantially increased content of CS in the tissues . In turn, the level of DS in a tissue depends on the type of tumor and is mostly reduced.…”
Section: The Metabolism Of Cs/ds Is Strongly Altered In the Tumor Stromamentioning
confidence: 99%
“…In turn, the level of DS in a tissue depends on the type of tumor and is mostly reduced. However, in some cancers such as liver, lung, pancreatic, colorectal and gastric cancers as well as in the breast fibroadenoma, the stromal content of DS is elevated . Nevertheless, in light of the significant CS accumulation, the CS/DS remodeling in the stroma of all of the human epithelial tumors can be considered to be a DS to CS shift.…”
Section: The Metabolism Of Cs/ds Is Strongly Altered In the Tumor Stromamentioning
confidence: 99%
“…These studies demonstrate that there is a downregulation in the tumour tissue of glypican-3 and syndecan-1 [25], an underrepresentation of complex N-glycans and α2,3-sialylation [126], a decrease of bisecting GlNAcylation, Lewis-type fucosylation [127], 9 N-glycans (M/Z 973 2+ , 1055 2+ , 1060 2+ , 1075 2+ , 1162 2+ , 1177 2+ , 1264 2+ , 1279 2+ , 1352 2+ ) [128], and a decrease of fucosylation levels and highly branched N-glycans in stage II CRC [129]. On the other hand, there is an increase in tumour tissue of glucosylceramide, lactosylceramide, monosialic acid ganglioside, globoside 4 [25], chondroitin sulphate, dermatan sulphate [130], high mannose, hybrid and paucimannosidic type N-glycans [126], α2,6-sialylation together with an increase in total sialylation in mid-to late tumours, mannose type N-glycan structures [127], glycan-Tn/STn-MUC1 [131], 3 N-glycans (M/Z 1013 2+ , 1116 2+ , 1228 2+ ) [128], overrepresentation of oligomannosidic, bi-antennary hypogalactosylated and branched compositions [100], and an increase in stage II CRC of sialylation levels and high-mannose glycans [129]. All biomarkers are summarized in Table 6.…”
Section: Glycomicsmentioning
confidence: 99%
“…The desmoplastic stroma provides structural and functional support in the cell growth of normal tissues and tumor nodules and protects cancer cells from immune cell attack and most therapeutic agents (Hodkinson et al, 2007;Keeratichamroen et al, 2018;Lee et al, 2018). Inside the tumor microenvironment, heparan sulfate (HS), one of the highly negatively charged sulfated GAGs, and related HS proteoglycans, HSPGs, mediate the activation of chemokines, enzymes and growth factors involved in cell-matrix interactions (Marolla et al, 2015;Rangel et al, 2018). During tumorigenesis, HS and HSPG are often overexpressed on the cell surface and accumulate on the tumor ECM in secreted and shedded forms, implicating that high-level HSPGs in tumor ECM contribute significantly to tumor progression (Naba et al, 2012;Kawahara et al, 2014).…”
Section: Introductionmentioning
confidence: 99%