Oxidative stress and plasma lipoproteins in cancer patients

Abstract

Objective To evaluate the relation between oxidative stress and lipid profile in patients with different types of cancer.Methods This was an observational cross-sectional. A total of 58 subjects were evaluated, 33 males, divided into two groups of 29 patients each: Group 1, patients with cancer of the digestive tract and accessory organs; Group 2 patients with other types of cancers, all admitted to a public hospital. The plasma levels (lipoproteins and total cholesterol, HDL, and triglycerides, for example) were analyzed by enzymatic kits, and oxidative stress based on thiobarbituric acid-reactive substances, by assessing the formation of malondialdehyde.Results In general the levels of malondialdehyde of patients were high (5.00μM) as compared to 3.31μM for healthy individuals. The median values of lipids exhibited normal triacylglycerol (138.78±89.88mg/dL), desirable total cholesterol values (163.04±172.38mg/dL), borderline high LDL (151.30±178.25mg/dL) and low HDL (31.70±22.74mg/dL). Median HDL levels in Group 1 were lower (31.32mg/dL) than the cancer patients in Group 2 (43.67mg/dL) (p=0.038). Group 1 also showed higher levels of oxidative stress (p=0.027).Conclusion The lipid profile of patients with cancer was not favorable, which seems to have contributed to higher lipid peroxidation rate, generating a significant oxidative stress.

Clinical and pathological findings of chronic actinic dermatitis

“…Since oxidative stress is considered to be one of the causes of CAD, 12 we have paid attention to some internal indicators related to oxidative stress such as albumin, uric acid, bilirubin, triglycerides, and cholesterol. [13][14][15] In our study, we found that serum level of albumin was decreased while uric acid was increased in CAD patients comparing to that in HCs. Serum albumin is a major antioxidant in extracellular fluids, and reduction in its levels has also been demonstrated to be associated with pemphigus vulgaris, asthma, and allergic rhinitis.…”

“…ROS can destroy cellular lipids, proteins, and DNA by directly attacking them and cause cell and tissue damage. Since oxidative stress is considered to be one of the causes of CAD, 12 we have paid attention to some internal indicators related to oxidative stress such as albumin, uric acid, bilirubin, triglycerides, and cholesterol 13‐15 . In our study, we found that serum level of albumin was decreased while uric acid was increased in CAD patients comparing to that in HCs.…”

Sensory changes and lipoprotein ratios in patients with brain cancers during cancer‐related therapy: A prospective cross‐sectional study

“…The reasons for the occurrence of sensory changes in cancer patients during periods of CRT (Kwekkeboom, ; Minniti et al, ; Stone and DeAngelis, ) were as follows: sensory changes are primarily caused by neurotoxicity; various processes can also occur as a result of neurotoxicity, which can affect sensory perception. During cancer treatment, tumor cells are destroyed or their growth is suppressed, but normal cells can be affected unintentionally (Maia et al, ). Many studies reported that the ROS levels in patients who received CRT is increased, and imbalance in ROS levels during CRT are known to cause neurotoxicity (Gupta et al, ).…”

“…The cellular macromolecules including DNA, protein, and lipids easily interact with ROS; the end products of lipid peroxidation can be used to detect excessive amounts of ROS in the human body (Barrera, ). Therefore, lipoprotein levels have been used as indicators of ROS production in the human body, and its ratio is more useful in predicting the ROS status compared with other individual indicators (Maia et al, ). Changes in sensory perception and lipoprotein levels can be inferred from the same mechanism during periods of CRT based on previous studies.…”

Oxidative stress, inflammation, psychological status, and severity of respiratory infections are negatively affected during the pre-contest period in amateur bodybuilders

“…CK was analyzed by the enzymatic method with commercial kits (Bioclin, Brazil). Lipid peroxidation (damage to lipids) was determined by thiobarbituric acid reactive substances (TBARS) and the results were calculated according to the standard curve made with MDA at 4Μm as previously described (Maia et al, 2014;De Moraes et al, 2017). For CP determination, 100μL aliquots of plasma were mixed in 600 μL of 10mM DNPH or 2M HCl (sample blank) and the tubes were kept at room temperature in the dark for 60 min.…”