Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice

Marinho, Rodolfo; Moura, Leandro Pereira de; Rodrigues, Bárbara de Almeida; Pauli, Luciana Santos Souza; Silva, Adelino Sánchez Ramos da; Ropelle, Eloize Cristina Chiarreotto; Souza, Cláudio Teodoro de; Cintra, Dennys Esper; Ropelle, Eduardo Rochete; Pauli, José Rodrigo

doi:10.1590/s1679-45082014ao2881

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Studies investigating the effects of aerobic training on modulation of pro-inflammatory molecules, such as JNK, TNF-α, IKK and others, and on improvement of insulin sensitivity have been published. ( 11 - 17 ) Investigations in rats with fat-rich diet-induced obesity revealed that aerobic exercise reduces molecules in the pro-inflammatory pathway, and increases intracellular insulin signaling, leading to increased sensitivity to this hormone. ( 13 , 14 , 16 ) However, further studies investigating the effects of different types of physical exercise on inflammatory markers associated with insulin resistance are warranted.…”

Section: Introductionmentioning

confidence: 99%

Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity

Guedes

Pieri

Luciano

et al. 2019

Einstein (São Paulo)

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Objective To evaluate the effect of three types of muscular resistance training on adiposity, inflammation levels and insulin activity in Swiss mice with fat-rich diet-induced obesity.Methods Lean and obese male Swiss mice were selected and allocated to one of eight groups comprising eight mice each, as follows: standard diet + no training; standard diet + muscular resistance training; standard diet + hypertrophy training; standard diet + strength training; high-fat diet + no training; high-fat diet + muscular resistance training; high-fat diet + hypertrophy training; high-fat diet + strength training. The training protocol consisted of stair climbing for a 10-week period. Blood samples were collected for lactate analysis, glucose level measurement and insulin tolerance test. After euthanasia, adipose tissues were removed and weighed for adiposity index determination. Fragments of epididymal adipose tissue were then embedded for histological analysis or homogenized for tumor necrosis factor alpha level determination using the ELISA method.Results Ausency of differences in total training volume and blood lactate levels overall emphasize the similarity between the different resistance training protocols. Body weight loss, reduced adipocyte area and lower adiposity index were observed in trained obese mice, regardless of training modality. Different training protocols also improved insulin sensitivity and reduced inflammation levels.Conclusion Resistance training protocols were equally effective in reducing body fat, inflammation levels and insulin resistance in obese mice.

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Section: Introductionmentioning

confidence: 99%

Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity

Guedes

Pieri

Luciano

et al. 2019

Einstein (São Paulo)

Self Cite

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“…Among these, the exercise therapy is useful in enhancing the physical strength and preventing complications, which are known to be effective in diabetes treatment [ 9 ]. Regular exercise reduces the glucose concentrations in the blood [ 10 ], increases the insulin sensitivity of the peripheral tissue including the muscles [ 11 ], and also helps to control the weight of obese diabetic patients [ 12 ]. Aerobic exercises are generally practiced by diabetic patients until now, but the elderly patients with diabetes have difficulty in performing exercises; this is because they have problems of diabetic complications or retrogression in functional capabilities due to obesity, degenerative arthritis, cardiovascular disease [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of muscle power training with elastic band on blood glucose, cytokine, and physical function in elderly women with hyperglycemia

Jin

Park

2015

Journal of Exercise Nutrition and Biochemistry

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[Purpose]The purpose of this study was to identify the effects of muscle power training with elastic band on body composition, glucose relation factor, and physical function in elderly women with hyperglycemia.[Methods]A total of 16 elderly women volunteered to participate in this study as subjects, and they were randomly assigned into one of the following two groups: muscle power training group (MPT: n = 8) and control group (CON: n = 8). The muscle power training group took exercise program using elastic band for 12 weeks, and the other group did not receive any exercise program during the same period. Before and after the experiment, both of the two groups received measurement in body composition (BMI, %Fat, skeletal muscle mass), glucose, cytokine (interleukin 6, adiponectin), and physical function (IPPB, grip strength). With these methods, the following conclusions were achieved.[Results]The results showed significant increases in adiponectin (p = 0.006), interleukin 6 (p = 0.018), SPPB (p = 0.024), and grip strength (P=.014). Blood glucose was significantly decreased in exercise group than contruo group.[Conclusion]It shows that the muscle power training with elastic band can give positive effects in elderly women with hyperglycemia.

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“…The technique has shown similar beneficial effects on obesity and hepatic steatosis in mouse models . The effect of exercise has mostly been investigated in the working skeletal muscle, where it has been shown to induce the transcription of genes involved in glucose and fatty acid metabolism and myogenesis . The liver plays a central role in glucose and lipid homeostasis.…”

Section: Introductionmentioning

confidence: 99%

“…11 The effect of exercise has mostly been investigated in the working skeletal muscle, where it has been shown to induce the transcription of genes involved in glucose and fatty acid metabolism and myogenesis. [12][13][14] The liver plays a central role in glucose and lipid homeostasis. Activities of gluconeogenic and lipogenic enzymes have been reported to increase and decrease, respectively, in response to physical activity.…”

Section: Introductionmentioning

confidence: 99%

Hepatic gene expression in mouse models of non‐alcoholic fatty liver disease after acute exercise

Piguet

Guarino

Potaczek

et al. 2019

Hepatology Research

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Aim Non‐alcoholic fatty liver disease (NAFLD) patients benefit from physical exercise. This study aimed to investigate the effect of acute exercise on hepatic gene expression in different mouse models of NAFLD. Methods C57BL/6J mice were fed with a control (CD) or a high fat (HFD) diet. AlbCrePtenflox/flox (Pten‐KO) and Fxr−/− mice, two genetic models of NAFLD with insulin hypersensitivity and resistance, respectively, were fed with CD. After 4 weeks, mice were randomly assigned to exercise or sedentariness. Mice were killed 15 min or 3 h after the running/sedentary period. Genome‐wide hepatic gene expression was evaluated with the Illumina Micro‐array platform. Quantitative polymerase chain reaction confirmed changes in gene expression. Results Acute exercise transiently affected the expression of genes involved in the immune response in C57BL/6 mice fed with CD and this effect normalized in the recovery phase. Acute exercise affected genes involved in gluconeogenesis in the insulin resistant Fxr−/− model. Genes involved in lipid metabolism were affected in C57BL/6 mice fed with CD, but not in mouse models of NAFLD. Genes involved in DNA damage response pathways were deregulated only in C57BL/6 mice fed with CD and not in mouse models of NAFLD. Conclusion The simultaneous analysis of different NAFLD models revealed that an acute exercise bout affects hepatic gene expression differentially according to animal models and that most of the differentially expressed genes are involved in glucose and fatty acid metabolism, immune regulation, and DNA damage response.

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Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice

Cited by 13 publications

References 28 publications

Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity

Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity

The effect of muscle power training with elastic band on blood glucose, cytokine, and physical function in elderly women with hyperglycemia

Hepatic gene expression in mouse models of non‐alcoholic fatty liver disease after acute exercise

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