Analysis of oxybutynin treatment for hyperhidrosis in patients aged over 40 years

Abstract

Objective:Our aim was to analyze the effectiveness of oxybutynin for hyperhidrosis treatment in patients over 40 years.Methods:Eighty-seven patients aged over 40 years were divided into two groups. One group consisted of 48 (55.2%) patients aged between 40 and 49 years, and another was composed of 39 (44.8%) patients aged over 50 years (50 to 74 years). A comparative analysis of Quality of Life and level of hyperhidrosis between the groups was carried out 6 weeks after a protocol treatment with oxybutynin. A validated clinical questionnaire was used for evaluation.Results:In the younger age group, 75% of patients referred a “partial” or “great” improvement in level of hyperhidrosis after treatment. This number was particularly impressive in patients over 50 years, in which 87.2% of the cases demonstrated similar levels of improvement. Over 77% of patients in both groups demonstrated improvement in Quality of Life. Excellent outcomes were observed in older patients, in which 87.1% of patients presented “slightly better” (41%) or “much better” (46.1%) improvement.Conclusion:Patients aged over 40 years with hyperhidrosis presented excellent results after oxybutynin treatment. These outcomes were particularly impressive in the age group over 50 years, in which most patients had significant improvement in Quality of Life and in level of hyperhidrosis.

Analysis of the Results of Videotoracoscopic Sympathectomy in the Treatment of Hyperhidrosis in Patients 40 Years or Older

“…The prevalence of this disease decreases with increasing age, especially after 40 years, which might be a result of good treatment at a younger age, including having already undergone surgery, a simple adaptation of these individuals to excessive daily sweating or simply an amelioration without physiological explanation. For all patients seeking medical (i.e., noninvasive) treatment for HH, a very popular initial choice is the use of oral oxybutynin, 16 especially for patients older than 40, who frequently have other comorbidities that increase the surgical risk. Many of these patients already use other daily tablets to control those concomitant diseases, and the addition of an oxybutynin tablet to their routine did not generate any of the discomfort mentioned by younger patients, who complained about the daily use of the medication.…”

Epidemiologic analysis of prevalence of the hyperhidrosis

“…Surgical treatment is contraindicated in individuals with a BMI greater than 25 due to the increased risk of severe compensatory HH; however, high BMI does not affect drug treatment with oxybutynin hydrochloride. 11 , 25 , 26 , 27 …”

Treatment of primary hyperhidrosis with oral anticholinergic medications: a systematic review

“…7,12,14 This improvement was demonstrated by both objective measurements 13 and patient questionnaire assessments. [7][8][9][10][11][12][13][15][16][17][18][19][20][21][22] Oxybutynin therapy does not demonstrate tachyphylaxis and patients continued to note symptom improvement in long-term studies. 15,[20][21][22] Methantheline bromide therapy for primary hyperhidrosis was assessed in a single randomized controlled trial 29 and showed a decrease in the symptoms of hyperhidrosis using both subjective (HDSS scoring) and objective (gravimetry) measures.…”