Hodgkin's disease and pregnancy: case series and proposal for treatment protocol

Abstract

The peak frequency of Hodgkin's disease convergesmatches with women of reproductive fertility age. Currently, this disease is the fourth more diagnosed neoplasia during pregnancy. In addition, there is no consensus in the literature on how to treat pregnant women because of the risks of chemotherapy for mothers and for fetuses. We report three cases of pregnant women with Hodgkin's disease. A review of the literature was made aiming to suggest a protocol to treat these patients.

Is Cytology Safest Modality Available in Armamentarium for Diagnosis of Hodgkin’s Lymphoma in Pregnancy?

“…Staging of a pregnant patient with HL should be based on history, physical examination, routine blood tests, and bone marrow biopsies, as well as on MRI or ultrasonography. [3] FNAC is a minimally invasive procedure which can be easily performed in pregnant females. Major procedures may lead to spontaneous labor.…”

“…She was advised for FNAC with the clinical suspicion of lymphoma and tuberculosis. Routine hematological investigations revealed haemoglobin of 12.5gm/dl, total leucocyte count of 10500 cells/mm 3 and platelet count of 296×10 rate was 30mm/hr. The iron profile was within normal limits.…”

Le lymphome malin Hodgkinien au cours de la grossesse; quelle modalité thérapeutique: à propos d'un cas et une revue de la littérature

“…Le PET Scanner doit être réalisé après l'accouchement pour évaluer la réponse thérapeutique. La stadification de la MDH durant la grossesse est basé sur l'histoire clinique, l'examen physique, les testes sanguins de routine et la biopsie osseuse, ainsi que l'IRM ou l'échographie qui peuvent être une bonne alternatives au scanner [ 2 , 3 ]. La prise en charge thérapeutique doit prendre en considération la période gestationnelle, le stade de la maladie, la localisation et la progression des signes et des symptômes.…”