Evaluation of microRNA expression in head and neck squamous cell carcinoma cell lines and in primary culture of oral keratinocytes

Andreghetto, Flávia Maziero; Klingbeil, María Fátima Guarizo; Soares, Renata M.; Sitnik, Roberta; Pinto, Décio dos Santos; Mathor, Mônica Beatriz; Nunes, Fábio Daumas; Severino, Patrícia

doi:10.1590/s1679-45082011ao2149

Cited by 1 publication

(3 citation statements)

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“…The results were organized into a database using the Statistical Package for the Social Sciences (SPSS) software, version 20.0. They were then submitted to a χ 2 test for association of variables. A significance level of 5% (p≤0.05) was adopted.…”

Section: Methodsmentioning

confidence: 99%

“…Listed as one of the most frequent malignant neoplasms worldwide, oral cavity cancers are a significant public health problem. 1 , 2 Most of these neoplasms stem from long-standing potentially malignant oral lesions (PMOL), partly due to the general public’s lack of knowledge about them and their associated etiologic factors. 1 …”

Section: Introductionmentioning

confidence: 99%

“…Os cânceres da cavidade oral representam um importante problema de saúde pública, sendo relacionados como uma das neoplasias malignas mais frequentes em todo o mundo. 1 , 2 A maioria dessas neoplasias é derivada de lesões orais potencialmente malignas (LOPM) existentes por um longo período de tempo, em parte por causa do desconhecimento da população sobre essas lesões e os fatores etiológicos a elas associados. 1 …”

Section: Introductionunclassified

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Potentially malignant oral lesions: clinicopathological correlations

Maia

Pinto

Pereira

et al. 2016

Einstein (São Paulo)

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Objective To determine the incidence of potentially malignant oral lesions, and evaluate and correlate their clinical and pathological aspects.Methods The sample consisted of cases clinically diagnosed as oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, and oral lichen planus treated at a diagnostic center, between May 2012 and July 2013. Statistical tests were conducted adopting a significance level of 5% (p≤0.05).Results Out of 340 patients, 106 (31.2%) had potentially malignant oral lesions; and 61 of these (17.9%) were submitted to biopsy. Actinic cheilitis was the most frequent lesion (37.5%) and the lower lip was the most affected site (49.6%). Among 106 patients in the sample, 48 (45.3%) reported nicotine consumption, 35 (33%) reported alcohol intake and 34 (32.1%) sun exposure while working. When clinical and histopathological diagnoses were compared, oral erythroplakia and atypical ulcer were the lesions that exhibited greater compatibility (100% each).Conclusion In most cases, clinical and histopathological diagnoses were compatible. An association between the occurrence of erythroplakia, leukoplakia and erythroleukoplakia with smoking was observed. Similarly, an association between actinic cheilitis and sun exposure was noted. Erythroleukoplakia presented the highest malignancy grade in this study. Finally, dental surgeons should draw special attention to diagnosis of potentially malignant oral lesions, choose the best management, and control the lesions to avoid their malignant transformation.

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Section: Methodsmentioning

confidence: 99%