Prevalence of erythrocyte alloimmunization in polytransfused patients

Cruz, Roberto de Oliveira; Mota, Márcia Maria Peruzzi Elia da; Conti, F; Pereira, Ricardo Antônio d'Almeida; Kutner, José Mauro; Aravechia, Maria Giselda; Castilho, Lilian

doi:10.1590/s1679-45082011ao1777

Cited by 9 publications

(7 citation statements)

References 27 publications

(29 reference statements)

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“…30% of patients who had symptoms related to the use of the blood component had had multiple "poly-transfusions". According to the parameter established by Cruz et al (41) , "poly-transfusion" takes place when a patient receives six or more units of packed red blood cells in three months. In the author's research, 3,044 patients in 12,904 were found to have undergone poly-transfusions, that is, a total of 23.6% of the population of the study.…”

Section: Discussionmentioning

confidence: 99%

Hemovigilance and patient safety: analysis of immediate transfusion reactions in elderly

2020

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Objective: To identify immediate transfusion reactions in elders hospitalized in a public hospital in the Federal District. Methods: This is an observational, retrospective, documental, and analytical research, with a quantitative analysis of 516 transfusions of packed red blood cells in elders hospitalized in the largest public hospital, who required blood components, from June to December 2017, through descriptive statistics. Results: The sample corresponded to 46.36% of the total number of transfusions in elders in the period. The mean age was 70 years old. There were adverse effects (reactions to the transfusion) in 12 (2.3%) transfusions. Respiratory alterations (33.3%) and fever (23.8%) were the most common events. Conclusion: The incidence of reactions to the transfusion is below national and international rates, indicating probable undernotification, which could be associated to a lack of knowledge regarding its clinical manifestations and the lack of systematic monitoring of the transfusion.

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Section: Discussionmentioning

confidence: 99%

Hemovigilance and patient safety: analysis of immediate transfusion reactions in elderly

2020

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“…16 Another study of 227 polytransfused patients in Sao Paulo, Brazil, reported the highest findings to be anti-E (22.06%), anti-D (13.18%), and anti-K (11.75%). 17 Meanwhile, in a study of 152 transfused patients from Medellín, Colombia, it was observed that the vast majority of antibodies in the samples could not be identified (23.68%), followed by the presence of anti-E (17.10%), autoantibodies (11.18%), and anti-K (10.53%). 18 Our study reported inconclusive results in 346 donor samples and 449 patient samples, corresponding to a significant number of unresolved cases in the national network, leading to the establishment of periodic guidelines and training to ensure the identification of irregular antibodies in donors and patients.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte antigens and antibodies in the Chilean population

et al. 2021

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Chile does not have a national registry of immunohematologic test results; there are no data on the prevalence of erythrocyte antigens and the frequency of antibodies in this population. Therefore, foreign references are used for decision-making. In this study, a standard questionnaire was used in 74 laboratories of public and private establishments. The information from tests conducted in 2015 was requested: ABO and D typing, antibody detection, antibody identification, and erythrocyte phenotype. Prevalence for the ABO-D phenotypes were obtained at the country level (D+ [94.4%] and D-[5.5%]) and differ from those recorded in the white population (85% and 15%, respectively). Positive antibody detection results were found in 0.4 and 1.3 percent of blood donors and patients, respectively; the main specificities were anti-Le a , -E, and -D in donors and anti-D, -E, and -K in patients. Inconclusive results were observed in ABO-D typing and antibody identification in donors and patients; these samples were referred to immunohematology reference laboratories for resolution. From this study, it was possible to estimate the prevalence of erythrocyte antigens and the frequency of antibodies at the national level, and this step allows us to characterize Chile's population of blood donors and transfusion recipients and to compare the results and frequencies with other populations or countries.

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“… 29 A combination of Rhesus system (anti-E, -D, -C) with anti-K were the most common specificities found in one study. 30 Because of this significant finding, the authors suggested that patients who have potential for multiple transfusion should be phenotyped for at least E and K antigens in addition to the ABO and RhD groups. The blood to be supplied also needed to match for these antigens to reduce the incidence of RBC alloimmunization.…”

Section: Discussionmentioning

confidence: 99%

“…The blood to be supplied also needed to match for these antigens to reduce the incidence of RBC alloimmunization. 30 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Red Blood Cell Alloimmunization among Transfused Chronic Kidney Disease Patients in Hospital Universiti Sains Malaysia

et al. 2020

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Objectives Red blood cell (RBC) immunization is a common complication in blood transfusion recipients. Patients with chronic kidney disease (CKD) eventually develop anemia, which is multifactorial, and requires regular blood transfusions, which exposes patients to the development of RBC antibodies. We sought to determine the prevalence and specificity patterns of RBC immunization and its risk factors among transfused CKD patients. Methods We conducted a cross-sectional study over one year from January to December 2018 in the Transfusion Medicine Unit, Hospital Universiti Sains Malaysia. A total of 249 samples were recruited from CKD patients who received a blood transfusion (at least one-pint), which only match for ABO and Rh(D) antigen. The serum was screened for the presence of the RBC antibody using the gel agglutination technique (Diamed gel cards). Samples with positive antibody screening were subjected to antibody identification. Results Of the 249 transfused CKD patients, 31 (12.4%) developed RBC immunization. Thirty (12%) were alloimmunized, and one (0.4%) was autoimmunized. Anti-Mia was the most common antibody (n = 14, 46.7%) among alloantibodies, followed by anti-E (n = 7, 23.3%). There was a significant association between pregnancy history with the development of antibodies whereas, no significant association was found between sociodemographic background, stage of CKD, hemodialysis status, underlying medical illness, and number of packed cell transfusions with the development of RBC antibodies. Conclusions One-eighth of our patient cohort had RBC alloimmunization, and the risk was increased in patients with a history of pregnancy. We propose Rhesus RBC phenotyping and to supply blood match Rhesus antigen in CKD patients, especially patients of reproductive age.

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Prevalence of erythrocyte alloimmunization in polytransfused patients

Cited by 9 publications

References 27 publications

Hemovigilance and patient safety: analysis of immediate transfusion reactions in elderly

Hemovigilance and patient safety: analysis of immediate transfusion reactions in elderly

Erythrocyte antigens and antibodies in the Chilean population

Prevalence of Red Blood Cell Alloimmunization among Transfused Chronic Kidney Disease Patients in Hospital Universiti Sains Malaysia

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