Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit

Zuo, Xiao-Shu; Liu, Yanan; Hu, Ke

doi:10.1590/s1678-9946202163020

Cited by 6 publications

(4 citation statements)

References 32 publications

(47 reference statements)

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“…Continuous surveillance plays a crucial role in controlling infections due to intrinsic antifungal-resistant species such as C. glabrata, which has a decreased susceptibility to azoles and resistance to amphotericin B. Candida glabrata candidemia is more common among the elderly and cancer patients. The ability of C. parapsilosis complex to colonize human skin is a commonly reported cause of catheter-related infections (11,12). Our study indicated that bloodstream infections due to C. albicans were common.…”

Section: Discussionmentioning

confidence: 63%

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Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Arabacı¹,

Aydemir²,

Ak³

et al. 2023

Jundishapur J Microbiol

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Background: Candida infections are a significant cause of morbidity and mortality in hospitalized patients. Acquired resistance to antifungal agents and strains with intrinsic resistance makes it hard to manage the infection. Objectives: We aimed to examine the risk factors of candidemia associated with patient mortality, the species causing candidemia, and their antifungal susceptibility. Methods: Patient data were collected from medical records retrospectively. MALDI-TOF MS was used to identify Candida species. Antifungal susceptibility testing was conducted by the colorimetric broth microdilution method. Results: A total of 155 patients were included in the study. The incidences of candidemia were 0.92, 0.72, 0.99, 0.97, and 2.28 per 1,000 cases in 2016, 2017, 2018, 2019, and 2020, respectively. Candida albicans accounted for 45% of all cases, followed by C. parapsilosis complex (28%), C. tropicalis (10%), and C. glabrata (8%). The 30-day crude mortality was 45%. There was no significant difference in mortality between C. albicans and non-albicans yeast species. The susceptibility rates for anidulafungin, micafungin, caspofungin, voriconazole, and fluconazole were as follows: 97%, 97%, 97%, 97%, and 90% in C. albicans, 95%, 95%, 98%, 72%, and 67% in C. parapsilosis complex, and 100%, 100%, 100%, 38%, and 63% in C. tropicalis. The susceptibility rates for anidulafungin, micafungin, and caspofungin in C. glabrata were 100%, 100%, and 92%, respectively. All 12 C. glabrata strains were susceptible-dose-dependent against fluconazole and uninterpretable for voriconazole. Conclusions: Incidences of candidemia and susceptibility patterns of strains may vary over time and amongst the regions. Candida albicans was the predominant strain, and echinocandins demonstrated the highest susceptibility rates against the most common species isolated in this study. Antifungal susceptibility tests are crucial in guiding patient treatment.

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Section: Discussionmentioning

confidence: 63%

“…Candidaalbicans was the most prevalent species, followed by C. parapsilosis among candidemia patients, according to many reports in the literature (6,9). On the contrary, C. parapsilosis has been reported as the most commonly isolated Candida strain in other studies (10,11).…”

Section: Discussionmentioning

confidence: 97%

Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Arabacı¹,

Aydemir²,

Ak³

et al. 2023

Jundishapur J Microbiol

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“…There are frequent reports on increased resistance by Candida species, such as fluconazole-resistant C. parapsilosis [5] and echinocandin-resistant C. glabrata [12]. In addition, there is increasing involvement of emerging species with intrinsic resistance profiles, such as C. krusei with resistance to fluconazole and C. auris, which is multiresististant [3,95].…”

Section: S Albidoflavusmentioning

confidence: 99%

“…It is estimated that invasive fungal infections (IFIs) affect the health of more than one billion people worldwide, causing the deaths of approximately 1.5 million every year [1,2]. These high rates of IFIs are related to the increased survival of patients in immunocompromised conditions, such as those with HIV and cancer, which predispose them to opportunistic infections caused by fungi [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Streptomyces: a natural source of anti-Candida agents

Martins,

Rodrigues da Silva,

Ratcliffe

et al. 2023

Journal of Medical Microbiology

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Introduction. There is an urgent need to source new compounds that can combat the current threat of serious infection caused by Candida spp. and contend with the problem of antimicrobial resistance. Gap. A synthesis of the evidence available from the current literature is needed to identify promising antifungal chemotherapeutics. Aim. To highlight anti-Candida compounds derived from Streptomyces spp. (a well-known source of antimicrobial compounds) that could translate to potential candidates for future clinical practice. Methodology. A comprehensive review was conducted across three scientific literature databases spanning a 13-year period. Results. We identified 151 compounds with anti-Candida activity. Amongst these, 40 were reported with very strong inhibitory activity, having minimum inhibitory concentrations (MICs) against Candida spp. of <3.5 µg ml−1, 66 compounds were considered strong inhibitors and 45 compounds exhibited moderate inhibitory potential. From an analysis of the MICs, we deduced that the actinomycin-like compounds RSP01 and RSP02 were probably the most promising anti-Candida compounds. Other antifungals of note included filipin-like compounds, which demonstrated superior inhibition to amphotericin B and activity against Candida glabrata and Candida krusei, and bafilomycin derivatives, which had substantial inhibition against Candida parapsilosis. Conclusion. It is essential to recognize the limitations inherent in the quest for new antifungals, which encompass toxicity, in vivo effectiveness and constraints associated with limited data access. However, further investigation through in-depth study and emerging technologies is of paramount importance, given that there are still many more compounds to discover. This review highlights the importance of antifungal compounds derived from Streptomyces , which demonstrate robust inhibition, and, in many cases, low toxicity, making them promising candidates for the development of novel antifungal agents.

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Prevention of hospital pathogen biofilm formation by antimicrobial peptide KWI18

Lima

Ramalho

Sandim

et al. 2022

Microbial Pathogenesis

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Epidemiology and risk factors of candidemia due to Candida parapsilosis in an intensive care unit

Cited by 6 publications

References 32 publications

Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Streptomyces: a natural source of anti-Candida agents

Prevention of hospital pathogen biofilm formation by antimicrobial peptide KWI18

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