Prevalence of anti-SARS-CoV-2 antibodies in outpatients of a large public university hospital in Sao Paulo, Brazil

Oliveira, Luanda Mara da Silva; Tiyo, Bruna Tiaki; Silva, Laís Teodoro da; Fonseca, Luiz Augusto Marcondes; Rocha, Rosana Coura; Santos, Vera Aparecida dos; Ceneviva, Carina; Bedin, Anderson; Almeida, Alexandre de; Duarte, Alberto José da Silva; Oshiro, Telma Miyuki

doi:10.1590/s1678-9946202062091

Cited by 10 publications

(4 citation statements)

References 11 publications

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“…Indeed, we identified a pattern in the data representing two regimes of disease spread where we could see distinct impacts of the isolation index on the disease spread, which are as follows. Here, we remark that herd immunity was not reached during the period under consideration in this study in any of the cities considered, as was observed by serological inquiries done in Brazil (see, for example, Oliveira et al., 58 or Buss et al. 41 for the most prominent case, of Manaus city), so that the reasons for reaching the peak in this case are mainly related to non-pharmaceutical interventions and intrinsic population contact patterns.…”

Section: Resultsmentioning

confidence: 47%

A snapshot of a pandemic: The interplay between social isolation and COVID-19 dynamics in Brazil

et al. 2021

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In response to the coronavirus pandemic, governments implemented social distancing, attempting to block the virus spread within territories. While it is well accepted that social isolation plays a role in epidemic control, the precise connections between mobility data indicators and epidemic dynamics are still a challenge. In this work, we investigate the dependency between a social isolation index and epidemiological metrics for several Brazilian cities. Classic statistical methods are employed to support the findings. As a first, initially surprising, result, we illustrate how there seems to be no apparent functional relationship between social isolation data and later effects on disease incidence. However, further investigations identified two regimes of successful employment of social isolation: as a preventive measure or as a remedy, albeit remedy measures require greater social isolation and bring higher burden to health systems. Additionally, we exhibit cases of successful strategies involving lockdowns and an indicator-based mobility restriction plan.

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Section: Resultsmentioning

confidence: 47%

A snapshot of a pandemic: The interplay between social isolation and COVID-19 dynamics in Brazil

et al. 2021

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“…Interestingly, in this study, the prevalence among those that restricted contact with family members and friends was lower (11.4%) than those that did not restrict contacts (28.9%), which is similar to the results observed in our study. In another study in a large university clinic in the region, using the same RDT, 13.9% of 439 outpatients July 2020 tested positive 14 . An evaluation using the ECLIA assay on vulnerable populations of the metropolitan area, showed higher rates, 43.8% (95% CI: 37.7-50%) 15 .…”

Section: Discussionmentioning

confidence: 94%

SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil

Matsuda

Oliveira

Campos

et al. 2022

Rev. Inst. Med. trop. S. Paulo

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The COVID-19 pandemic in Brazil has been marked by high infection and death rates. The immune response generated by current vaccination might be influenced by previous natural infection, and baseline estimates may help in the evaluation of vaccine-induced serological response. We evaluated previous SARS-CoV-2 testing (RT-PCR), and performed rapid diagnostic tests (RDT) and high throughput electrochemiluminescence immunoassay (ECLIA) before vaccination among people living with HIV (PLWH), users of antiretroviral prophylaxis (PrEP/PEP), and healthcare professionals in an HIV outpatient clinic (HCP-HC). RDT was positive in 25.7% (95% CI: 19-33%) overall, 31.3% (95% CI : 18-45%) among PLWH, 23.7% (95% CI : 14-34%) in PrEP/PEP users and 21.4% (95% CI : 05-28%) in HCP-HC (p=0.548). Diagnostic RT-PCR testing was very limited, even for symptomatic individuals, and whereas all HCP-HC had one test perfomed, only 35% of the patients (PREP/ PEP/PLWH) were tested (p<0.0001). Adequate monitoring of post-vaccination humoral response and breakthrough infections including those in asymptomatic cases are warranted, especially in immunologically compromised individuals.

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“… 22 , 23 This serological proportion found in asymptomatic PLHIV confirms the scale of the spread of the SARSCoV- 2. Oliveira et al found that 13.9% (61/439) of outpatients were IgG positive even though 32.8% of patients testing positive for anti-SARS-CoV-2 IgG antibodies were asymptomatic 24 while among healthcare professionals, the seroprevalence of IgM/IgA and IgG anti-SARS-CoV-2 antibodies was 24.24%. 25 Also, the expression of CRP, an indicator of the degree of inflammation in an organism, was relatively higher in COVID-19 IgG positive individuals (7.95±12.5mg/L) than negative individuals (6.26±6.92mg/L; p=0.37).…”

Section: Discussionmentioning

confidence: 99%

Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso

Sagna

Ouédraogo

Traoré

et al. 2022

J Public Health Afr

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The severe acute respiratory syndrome due to the new coronavirus (SARS-CoV-2), responsible for coronavirus disease (COVID-19), has severely tested the global health response capacity, with predictions of a fatality for developing countries. To evaluate the prevalence of anti-SARS-CoV- 2 antibodies in People Living with HIV (PLHIV) with no COVID-19 symptoms in Burkina Faso. Seroprevalence was estimated by performing a qualitative screening test for SARS-CoV-2-specific immunoglobulins. The STANDARDTM Q COVID-19 IgM/IgG Combo Test kit from SD BIOSENSOR was used. Parameters like HIV plasma viral load, CD4 T cell count and C-Reactive Protein (CRP) expression were estimated. This study enrolled a total of 200 PLHIV aged 4-87 years who are asymptomatic for COVID-19. There were 36 (18%) positive for SARS-CoV-2 IgM and/or IgG of which three (1.50%) were positive for SARS-CoV-2 IgM and 33 (16.50%) for IgG. Among participants diagnosed as IgM positive, 66.67% (2/3) had the highest HIV viral loads with the lowest CD4 T cell counts (p<0.0001). The expression of CRP was relatively higher in COVID-19 IgG positive individuals (7.95±12.5 mg/L) than negative individuals (6.26±6.92 mg/L; p=0.37). The rate of IgG and IgM SARS-CoV-2 immunoglobulin carriage (18%), accompanied by a relatively high CRP levels, was revealed in this study among PLHIV. This serologic evidence and mild inflammation suggest that Burkina Faso escaped the worst, not necessarily because there were not many SARS-CoV-2 infections in its population, but because factors including genetic and environmental, might have resulted in many asymptomatic carriers.

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Prevalence of anti-SARS-CoV-2 antibodies in outpatients of a large public university hospital in Sao Paulo, Brazil

Cited by 10 publications

References 11 publications

A snapshot of a pandemic: The interplay between social isolation and COVID-19 dynamics in Brazil

A snapshot of a pandemic: The interplay between social isolation and COVID-19 dynamics in Brazil

SARS-CoV-2 testing among patients and healthcare professionals in an HIV outpatient clinic in Brazil

Enigma of the high prevalence of anti-SARS-CoV-2 antibodies in HIV-positive people with no symptoms of COVID-19 in Burkina Faso

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