Pregnancy and COVID-19: management and challenges

Abstract

This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Being pregnant in the COVID‐19 pandemic: Effects on the placenta in all aspects

“…A total of seven placentas, two placentas from pregnant women regaining from COVID‐19 in the first trimester (Group I), three placentas from women that gave birth during the acute stage of COVID‐19 (Group II), and two placentas from pregnant women regaining from COVID‐19 in the third trimester (Group III) were examined in the study of Wenling et al According to the study, placental histopathology was found normal through Group I, intervillous and subchronic fibrin were identified in the placentas of Group II, and extensive thrombotic vasculopathy on the fetal side was observed in the placentas of Group III. Additionally, intrauterine growth restriction, oligohydramnios, and small for gestation newborns were reported for Group III 26 . Menter et al 31 found prominent lymphohistiocytic villitis and intervillositis, signs of maternal and fetal malperfusion, among the placentas of 40th and 41st gestational weeks, and Mongula et al 32 reported increased perivillous fibrin deposition and intervillositis according to their study.…”

“…Therefore, although everything has not yet been fully demonstrated, pregnant women and newborns need special attention in order to be prevented from COVID-19. 26 Taken together, because of the direct effects of the virus on mothers, a healthy pregnancy needs an early diagnosis of COVID-19 and to take appropriate protection at an early stage by calculating the potential risks of treatment on the fetus.…”

“…There is currently no evidence to support the fetal SARS‐CoV‐2 infection by vertical transmission, but more articles began to report maternal deaths; for instance, 124 maternal deaths were reported in Brazil 26 . Additionally, about five newborns who showed positive results for COVID‐19 were reported according to their swab tests 30 h after birth or 17 days after birth, although they did not show any symptoms 21,26 . There was no direct evidence of vertical transmission among these neonates, but it should be noted that amniotic fluid, umbilical cord blood, or placenta of these newborns were not tested 26 .…”

“…Unlike, according to the study of Vivanti et al, 27 COVID‐19 positive pregnant at 35 + 2 weeks of gestation had given birth due to increased respiratory distress, and after that, RT‐PCR (reverse transcription polymerase chain reaction) on the placenta was positive for SARS‐CoV‐2 genes. Therefore, although everything has not yet been fully demonstrated, pregnant women and newborns need special attention in order to be prevented from COVID‐19 26 …”

Peripartum Covid-19 Pneumonia with Severe ARDS – A Case Report

“…Due to the lack of data, the effects on pregnant women and their newborn are still unclear. Recent data shows that pregnant women with SARS-CoV-2 infections are at increased risk of severe illness and an adverse outcome, such as admission to the ICU, mechani-cal ventilation, preterm birth, and pregnancy loss [7][8][9][10][11][12]. Older research does not indicate that pregnant women are at a greater risk of complications from infection than non-pregnant patients [13,14].…”