Atypical clinical presentation of an Arthroderma gypseum infection in a renal transplant recipient

Belda, Walter; Criado, Paulo Ricardo

doi:10.1590/s1678-9946202062042

Cited by 3 publications

(1 citation statement)

References 16 publications

(20 reference statements)

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“…When immunity is weakened, deep infection by dermatophytes leads to infiltration of the skin and subcutaneous tissue, and causes lesions of the lymph nodes, internal organs, and central nervous system [ 9 ]. Walter et al [ 10 ] reported a case of granulation tissue in the ankle joint following an M. gypseum deep infection in a renal transplant recipient. However, knowledge gaps surrounding the immune system response to M. gypseum pose barriers to the comprehensive understanding of this infection.…”

Section: Introductionmentioning

confidence: 99%

Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response

Liu

et al. 2022

IJMS

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Microsporum gypseum causes dermatomycoses in giant pandas (Ailuropoda melanoleuca). This study aimed to investigate the immune response of M. gypseum following deep infection. The degree of damage to the heart, liver, spleen, lungs, and kidneys was evaluated using tissue fungal load, organ index, and histopathological methods. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) detected the mRNA expression of receptors and cytokines in the lung, and immunofluorescence staining and flow cytometry, were used to assess immune cells in the lung. The results indicated that conidia mainly colonized the lungs and caused serious injury with M. gypseum infection. Furthermore, dectin-1, TLR-2, and TLR-4 played a role in recognizing M. gypseum cells. Numerous inflammatory cells, mainly macrophages, dendritic cells, polymorphonuclear neutrophils, and inflammatory cytokines (TGF-β, TNF-α, IL-1β, IL-6, IL-10, IL-12, and IL-23), were activated in the early stages of infection. With the high expression of IL-22, IL-17A, and IL-17F, the Th17 pathway exerted an adaptive immune response to M. gypseum infection. These results can potentially aid in the diagnosis and treatment of diseases caused by M. gypseum in giant pandas.

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Section: Introductionmentioning

confidence: 99%

Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response

Liu

et al. 2022

IJMS

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Azathioprine/ciclosporin/prednisone

2020

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Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients

Silva

Sousa

Toscano

et al. 2022

Anais Brasileiros de Dermatologia

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Atypical clinical presentation of an Arthroderma gypseum infection in a renal transplant recipient

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 3 publications

References 16 publications

Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response

Microsporum gypseum Isolated from Ailuropoda melanoleuca Provokes Inflammation and Triggers Th17 Adaptive Immunity Response

Azathioprine/ciclosporin/prednisone

Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients

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