Increased serum gastrin in patients with different clinical forms of Chagas disease coinfected with Helicobacter pylori

Abstract

Trypanosoma cruzi and Helicobacter pylori (HP) are pathogens that cause chronic diseases and have been associated with hypergastrinemia. The aim of this study was to evaluate the fasting gastrin levels in patients with different clinical forms of Chagas disease (CD), coinfected or not by HP. The enrolled individuals were outpatients attending at the university hospital. HP infection was assessed by serology and 13 C-urea breath test. Fasting serum gastrin concentration was measured by chemiluminescence assay. Gastric endoscopic and histological features were also evaluated. Associations between CD and serum gastrin level were evaluated in a logistical model, adjusting for age, gender and HP status. A total of 113 patients were evaluated (45 with Chagas disease and 68 controls). In the multivariate analysis, increasing serum gastrin levels (OR= 1.02; 95% CI= 1.01-1.12), increasing age (OR= 1.05; 95% CI= 1.02 - 1.09) and HP-positive status (OR = 2.88; 95% CI = 1.10 - 7.51) remained independently associated with CD. The serum gastrin levels were significantly higher in the group of patients with the cardiodigestive form ( P = 0.03) as well as with digestive form ( P = <0.001) of Chagas disease than in the controls. In conclusion, patients with cardiodigestive and digestive clinical forms of CD have increased basal serum gastrin levels in comparison with controls. Moreover, we also demonstrated that H. pylori coinfection contributes to the hypergastrinemia shown in CD.

Analysis of gastrin‐17 and its related influencing factors in physical examination results

“…The changes of serum G17 level can reflect the state of gastric mucosal lesions, so it can serve as a screening index for gastric cancer and precancerous diseases 9 . In our study, as with other researches, G17 level was not different in different sex, age and BMI 10 . However, several previous studies have reported that G17 level is remarkably higher in females than in males, and speculated that the results may be related to hormonal changes that occur during menopause 11 .…”

“…9 In our study, as with other researches, G17 level was not different in different sex, age and BMI. 10 However, several previous studies have reported that G17 level is remarkably higher in females than in males, and speculated that the results may be related to hormonal changes that occur during menopause. 11 G17 is unstable and its expression level is affected by many factors (regions, lesion location, atrophic degree, etc.).…”

Analysis of serum gastrin‐17 and Helicobacter pylori antibody in healthy Chinese population

“…This difference may be related to the changes in hormones that occur in women during menopause. Some previous studies have reported differences in serum G‐17 levels between males and females, while some others have reported no difference 12‐14 . G‐17 is an unstable indicator which is affected by many factors.…”

Efficacy and safety of 7 days versus 10 days triple therapy based on levofloxacin-dexlansoprazole for eradication of Helicobacter pylori: A pilot randomized trial

“…[ 27 ] The relation between eradication failure of H. pylori and foods, caffeinated beverages as coffee/tea and smoking that lowering the pH of the stomach, is mentioning because the low pH of the stomach promotes the growth of H. pylori pathogen and decreasing efficacy of antibiotics as well. [ 21 ]…”

“…The minimal inhibitory concentrations (MIC) and low bactericidal concentrations of most antibiotics used for eradication of H. pylori are pH-dependent of the stomach, at pH values <7.4 the MIC increases. [ 20 21 ] Thus, we take into consideration the effect of foods that trigger acid reflux on the efficacy of dexlansoprazole and subsequently the efficacy of levofloxacin and amoxicillin in H. pylori eradication.…”