Disseminated Clonal Complex 5 (CC5) methicillin-resistant Staphylococcus aureus SCCmec type II in a tertiary hospital of Southern Brazil

Duarte, Felipe Crepaldi; Tavares, Eliandro Reis; Danelli, Tiago; Ribeiro, Maria Alice Galvão; Yamauchi, Lucy Megumi; Yamada‐Ogatta, Sueli Fumie; Perugini, Marcia Regina Eches

doi:10.1590/s1678-9946201860032

Cited by 5 publications

(9 citation statements)

References 19 publications

(31 reference statements)

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“…Thus, our findings may 5/7 reflect the changes in the prevalence of MRSA clones involved with nosocomial infections in Brazil. This epidemiologic change has been observed in other national studies, wherein the prevalence of new clones has become increasingly common [18][19][20] .…”

Section: Discussionsupporting

confidence: 57%

“…The predominance of SCCmec type II (34/52, 65.4%) was also observed among the MRSA strains isolated from patients with bloodstream and respiratory tract infections during 2015-2016 in the University Hospital of Londrina in the Parana State, Brazil 20 . Interestingly, the predominance of MRSA strains harboring SCCmec II elements was also observed in a study during 2010 to 2013 in the same hospital 21 .…”

Section: Discussionmentioning

confidence: 74%

“…Interestingly, the predominance of MRSA strains harboring SCCmec II elements was also observed in a study during 2010 to 2013 in the same hospital 21 . These data suggest the shift in the MRSA population and emphasizes on the substitution of the strains harboring SCCmec III with those carrying SCCmec II that is becoming prevalent in some areas 19,20 .…”

Section: Discussionmentioning

confidence: 86%

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Differences in resistance profiles and virulence genes among methicillin-resistant and methicillin-susceptible Staphylococcus aureus of different lineages at a public tertiary hospital

Bride

Pereira

Barbosa

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 86%

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Differences in resistance profiles and virulence genes among methicillin-resistant and methicillin-susceptible Staphylococcus aureus of different lineages at a public tertiary hospital

Bride

Pereira

Barbosa

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…Staphylococcus aureus can interact with its host as a commensal member of the microbiota [1] or as an opportunistic pathogen causing a wide range of community and hospitalassociated infections [2][3][4][5][6][7]. In humans, this bacterium can colonize multiple body sites, but the nose (anterior nares) is the frequent ecological niche of S. aureus carriage.…”

Section: Introductionmentioning

confidence: 99%

Nasal Carriage by Staphylococcus aureus among Healthcare Workers and Students Attending a University Hospital in Southern Brazil: Prevalence, Phenotypic, and Molecular Characteristics

Danelli

Duarte

Oliveira

et al. 2020

Interdisciplinary Perspectives on Infectious Diseases

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Background. Staphylococcus aureus can asymptomatically colonize the human anterior nares and skin, and nasal colonization by this bacterium represents a potential risk for development of invasive infections. The aim of this study was to determine the prevalence of S. aureus nasal carriage among healthcare workers and students attending a university hospital and to characterize the isolates phenotypically and molecularly. Methods. A cross-sectional study was performed with 324 volunteers. Cultures from nasal samples were obtained and S. aureus isolates were characterized according to their antimicrobial susceptibility profile and four virulence factors-encoding genes. MRSA isolates were characterized regarding their oxacillin/cefoxitin susceptibility, SCCmec, and REP-PCR types. Potential risks for S. aureus and MRSA carriage were analyzed. Results. Of 324 nasal samples, 42.9% were identified as S. aureus, of which 28.8% were MRSA. S. aureus carriers were significantly higher in males and students (OR = 2.898, 95%CI 1.553–5.410); however, no variables were associated with MRSA carriage. All isolates were susceptible to vancomycin and the highest rate of resistance was observed for penicillin (90.6%). All isolates harbored the coa gene, and 97.8%, the icaA gene; 15.8% and 6.5% were positive for tst and lukS-PV/lukF-PV genes, respectively. Among MRSA isolates, 45% carried the mecA gene but were phenotypically susceptible to oxacillin/cefoxitin; two harbored the tst and none had lukS-PV/lukF-PV genes. All MRSAs were distributed into six SCCmec types and type I (62.5%) was the most frequent. REP-PCR typing identified four main clusters among MRSA isolates. Conclusion. High prevalence of healthcare workers and students were identified as nasal carriers of S. aureus exhibiting different antimicrobial resistance profiles, including mecA-positive oxacillin-susceptible S. aureus (OS-MRSA) and the presence of virulence-encoding genes. Both cohorts may represent potential sources for the emergence of a successful S. aureus strain highly adapted to the hospital environment.

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“…Relevantly, the New York/Japan clone, which carries SCC mec type II, was shown to become resistant to daptomycin, tigecycline, and vancomycin [ 67 , 110 ]. In addition, such a clone was shown to become capable of producing α -hemolysin and PVL and forming a biofilm [ 14 , 104 , 105 ]. Thus, multiresistance and virulence remained evolutionary events among MRSA clones.…”

Section: Introductionmentioning

confidence: 99%

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

Andrade

Luiz

Souza

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Since the emergence of MRSA in the 1960s, a gradual increase in infections by resistant bacteria has been observed. Clinical manifestations may vary from brand to critical condition due to host risk factors, as well as pathogen virulence and resistance. The high adaptability and pathogenic profile of MRSA clones contributed to its spread in hospital and community settings. In Brazil, the first MRSA isolates were reported in the late 1980s, and since then different genetic profiles, such as the Brazilian epidemic clone (BEC) and other clones considered a pandemic, became endemic in the Brazilian population. Additionally, Brazil’s MRSA clones were shown to be able to transfer genes involved in multidrug resistance and enhanced pathogenic properties. These events contributed to the rise of highly resistant and pathogenic MRSA. In this review, we present the main events which compose the history of MRSA in Brazil, including numbers and locations of isolation, as well as types of staphylococcal cassette chromosome mec (SCCmec) found in the Brazilian territory.

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Disseminated Clonal Complex 5 (CC5) methicillin-resistant Staphylococcus aureus SCCmec type II in a tertiary hospital of Southern Brazil

Cited by 5 publications

References 19 publications

Differences in resistance profiles and virulence genes among methicillin-resistant and methicillin-susceptible Staphylococcus aureus of different lineages at a public tertiary hospital

Differences in resistance profiles and virulence genes among methicillin-resistant and methicillin-susceptible Staphylococcus aureus of different lineages at a public tertiary hospital

Nasal Carriage by Staphylococcus aureus among Healthcare Workers and Students Attending a University Hospital in Southern Brazil: Prevalence, Phenotypic, and Molecular Characteristics

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

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