American tegumentary leishmaniasis: diagnostic and treatment challenges in a clinical case

Oyama, Jully; Ferreira, Fabiana Borges Padilha; Conter, Carolina Cella; Lera‐Nonose, Daniele Stéfanie Sara Lopes; Ramos‐Milaré, Áquila Carolina Fernandes Herculano; Venazzi, Eneide Aparecida Sabaini; Silveira, Thaís Gomes Verzignassi; Lonardoni, Maria Valdrinez Campana

doi:10.1590/s1678-9946201860003

Cited by 8 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this hypothesis needs additional research, as there is no data on previous treatment sought by the patients. Previously, studies have identified incorrect diagnoses, such as chronic rhinitis, in cases of leishmaniasis presenting nasal obstruction [ 18 ]; and, especially in cases with unusual manifestations, such as lips single lesion [ 10 ], there were a high number of delayed correct diagnoses, resulting in the worsening of the lesions over time [ 23 ]. Lesions in the pharynx were associated with leishmaniasis, being present in almost one-quarter of the cases, and, in the majority of them, with concomitant oral involvement, as described in a previous study [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis

Vicente

Falqueto

2018

PLoS ONE

View full text Add to dashboard Cite

Mucocutaneous leishmaniasis and paracoccidioidomycosis are infectious diseases with similar epidemiological and clinical aspects. Cases of both diseases may manifest similar lesions in the mucosa. Therefore, the determination of distinguishing characteristics for the purpose of differential diagnosis is critical for better management of the diseases. The present study evaluated factors that assist in the differentiation of mucosal lesions between these diseases. This cross-sectional study included data from medical records of 122 cases of mucocutaneous leishmaniasis and 83 cases of paracoccidioidomycosis attended at the university hospital Cassiano Antonio Moraes, located in Vitória, Espírito Santo State, Brazil. Comparison between the diseases included the following variables: sex, age, time of disease evolution, location of the lesion and symptoms. Adults and males were affected by both diseases at higher rates. Lesions in the nasal region (95.1%; p-value = 0.000) and the pharynx (20.5%; p-value = 0.009) and nasal obstruction (34.4%; p-value = 0.000) were associated with leishmaniasis. Paracoccidioidomycosis was associated with lesions in the oral region (90.4%; p-value = 0.000), oral pain (16.9%; p-value = 0.000), and hoarseness (14.5%; p-value = 0.008). In leishmaniasis, lesions in oral regions were not associated with oral pain and were frequently located close to the nasal area. The manifestations cited above could improve the differential diagnosis of leishmaniasis and paracoccidioidomycosis, and thereby potentially aid in the choice of appropriate confirmatory diagnostic testing.

show abstract

Section: Discussionmentioning

confidence: 99%

Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis

Vicente

Falqueto

2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Health education is considered an important tool in controlling leishmaniasis 13 . Of note, the delay and failure in the early diagnosis leading to health worsening, often evidence the negligence of the disease by health professionals 12 , 14 , 15 . In the present case, 20 days have passed since the appearance of the first symptoms until the definitive diagnosis.…”

Section: Discussionmentioning

confidence: 64%

First report of an autochthonous human visceral leishmaniasis in a child from the South of Minas Gerais State, Brazil

Narciso

Carvalho

Campos³

et al. 2018

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

American visceral leishmaniasis (VL) is a vector-borne disease transmitted by some species of phlebotomine sandflies from the genus Lutzomyia. This neglected tropical zoonosis shows increasing urbanization process, since the end of the 1980s. After the emergence of foci of the disease in urban areas, VL has assumed an important role in public health. Although VL is widely prevalent in several parts of the world, diagnosing the illness is still difficult. We present a case of a 12-year-old girl with a history of recurrent fever, anorexia, cachexia, chronic fatigue, weight loss, left palpebral unilateral edema, persistent cough and pancytopenia. A diagnosis of VL was performed using a reference immunochromatographic rapid test. Identification of the infecting protozoan was directly obtained by PCR of bone marrow. The patient responded favorably to treatment using liposomal amphotericin B. This is the first report of human visceral leishmaniasis in the city of Lavras in the South of Minas Gerais State. This first report of VL highlighted the need of maintenance of permanent surveillance and control programs in the city of Lavras, including the active search of sandflies, human and canine cases. The current situation of Lavras should also be taken as an alert to other near cities where favorable eco-epidemiological conditions may exist.

show abstract

“…nausea, vomiting, diarrhea and headache) are important limitations faced by affected patients (3,4). Besides, ulcerated lesions caused by CL manifestation promote severe tissue destruction and impacts on life quality (5). Thus, a new cost-effective strategy to combat safely CL is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Preclinical Investigation of Methylene Blue‐mediated Antimicrobial Photodynamic Therapy on Leishmania Parasites Using Real‐Time Bioluminescence

Cabral

Sabino

Dimmer

et al. 2019

Photochem & Photobiology

View full text Add to dashboard Cite

Cutaneous leishmaniasis (CL) is a neglected disease that promotes destructive lesions. Difficulties in treatment are related to accessibility of drugs, resistance and toxicity. Antimicrobial photodynamic therapy (APDT) has been emerging as a promising treatment for CL. In this work, we evaluated methylene blue (MB)‐mediated APDT (MB‐APDT) on Leishmania amazonensis in vitro and in vivo by bioluminescence technique. In vitro, MB‐APDT was performed using a red LED (λ = 660 ± 11 nm, 100 mW cm−2) and MB (100 µm) at different light doses. In vivo, mice were infected and 4 weeks later, randomly divided into three groups: control, APDT 1 (single session) and APDT 2 (two sessions of MB‐APDT). MB was used at 100 µm and energy dose was established at 150 J cm−2. Parasite burden, lesion size and pain were evaluated weekly for 4 weeks. In vitro, lethal dose for 90% parasite inactivation was achieved at 48.8 J cm−2. In vivo, although APDT 1 and APDT 2 groups have showed similar parasite burden after 4 weeks, two sessions were clinically better, especially considering the inflammatory process associated to CL. Our findings reinforce MB‐APDT as a cost‐effective treatment to combat CL.

show abstract

American tegumentary leishmaniasis: diagnostic and treatment challenges in a clinical case

Cited by 8 publications

References 3 publications

Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis

Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis

First report of an autochthonous human visceral leishmaniasis in a child from the South of Minas Gerais State, Brazil

Preclinical Investigation of Methylene Blue‐mediated Antimicrobial Photodynamic Therapy on Leishmania Parasites Using Real‐Time Bioluminescence

Contact Info

Product

Resources

About