Leishmania infantum AS A CAUSATIVE AGENT OF CUTANEOUS LEISHMANIASIS IN THE STATE OF MATO GROSSO DO SUL, BRAZIL

Castro, Ludiele Souza; França, Adriana de Oliveira; Ferreira, Eduardo; Filho, Günther Hans; Júnior, Minoru German Higa; Gontijo, Célia Maria Ferreira; Pereira, Agnes Antônia Sampaio; Dorval, Maria Elizabeth Moraes Cavalheiros

doi:10.1590/s1678-9946201658023

Cited by 24 publications

(22 citation statements)

References 24 publications

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“…These lesions ulcerate, evolve over time and do not present a hypopigmented halo . These characteristics differ from the data presented in our study and by other authors regarding the disease observed in Central America where the lesions do not ulcerate regardless of the evolution time and are often surrounded by a hypopigmented halo . In both South America and Central America, patients do not have a previous history of VL.…”

Section: Discussioncontrasting

confidence: 99%

Histopathological features of skin lesions in patients affected by non‐ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America

Pacheco

Araujo

Ferreira³

et al. 2018

Int J Experimental Path

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Summary In Honduras visceral leishmaniasis and non‐ulcerated or atypical cutaneous leishmaniasis (NUCL) are caused by the species Leishmania (L.) infantum chagasi. NUCL is the most common clinical form in the southern regions of the country, mainly affecting the young. In view of the lack of knowledge about the pathogenesis of the disease pattern caused by L. (L) infantum chagasi in individuals affected by NUCL, the aim of the present study was to describe in detail the histopathological features of the skin lesion caused by the parasite. Biopsies from human NUCL lesions with a positive parasitological diagnosis were collected and processed using standard histological techniques. Paraffin sections stained by haematoxylin and eosin were used to examine the histopathological alterations seen in the skin. The lesions varied between 3 and 5 mm, and the majority of the patients (60%) had a single lesion. Lesions were more frequently seen in females (65%), with an average age of 33.4 years. Microscopically, the skin lesions were characterized by mononuclear inflammatory infiltrate in the dermis composed of lymphocytes, macrophages and a few plasma cells. The intensity of the infiltration varied from discrete to intense. In both cases, the parasitic infection was discrete. Granulomas were present in 60% of cases and were associated with intense inflammation. The data revealed by the histopathological alterations in the skin of individuals affected by NUCL suggest activation of a cellular immune response that potentially controls parasite spreading.

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Section: Discussioncontrasting

confidence: 99%

Histopathological features of skin lesions in patients affected by non‐ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America

Pacheco

Araujo

Ferreira³

et al. 2018

Int J Experimental Path

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“…Adult infection rates are increasing while those in children have decreased [23], probably due to improvements in nutrition and immunization rates for other diseases. Atypical cutaneous leishmaniasis caused by L. infantum has also been described in the country [24,25]. In such circumstances, the diagnosis based strictly on visual inspection of clinical signs lacking proper Leishmania species identification leads to the misassumption of a low risk of VL in the region, further complicating the management of the spread of the parasite and challenging disease surveillance and control.…”

Section: Introductionmentioning

confidence: 99%

Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

Boité

Späth

Bussotti

et al. 2019

Genes

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Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of Leishmania infantum in the Americas into the Neotropics during European colonization represents a unique case study to investigate the mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive L. infantum fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on L. infantum genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of visceral leishmaniasis (VL) in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in L. infantum to understand the parasite’s successful establishment on the continent.

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“…We suppose that the samples regarded as containing solely C. fasciculata originated from a mixed infection by this trypanosomatid with L. infantum. This leishmania, typically causing visceral leishmaniasis [16], is known to occasionally produce cutaneous disease [17][18][19]. Moreover, such cases are known from Iran [20,21].…”

Section: Dear Editorsmentioning

confidence: 99%

On monoxenous trypanosomatids from lesions of immunocompetent patients with suspected cutaneous leishmaniasis in Iran

Kostygov

Butenko

Yurchenko

2018

Tropical Med Int Health

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Leishmania infantum AS A CAUSATIVE AGENT OF CUTANEOUS LEISHMANIASIS IN THE STATE OF MATO GROSSO DO SUL, BRAZIL

Cited by 24 publications

References 24 publications

Histopathological features of skin lesions in patients affected by non‐ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America

Histopathological features of skin lesions in patients affected by non‐ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America

Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

On monoxenous trypanosomatids from lesions of immunocompetent patients with suspected cutaneous leishmaniasis in Iran

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