Non-association between anti-Toxoplasma gondii antibodies and ABO blood group system

Abstract

Toxoplasma gondii infects humans through the gastrointestinal tract (GIT), which elicits humoral immune response with specific antibodies. The expression of the ABO blood group glycoconjugates also occurs in this same system and may influence the human susceptibility of infection by T. gondii. The aim of the present study was to investigate the association between ABO blood group phenotypes and the presence of anti-T. gondii antibodies. Data -including age, results of serology tests for T. gondii infection and ABO blood group phenotypes -were assembled from the medical records of 1,006 pregnant women attended in the Base Hospital of the Medical School of São José do Rio Preto, Brazil, between 2001 and 2004. The chi-square test was used to compare the results with the level of significance set at 5%. Of the studied cases, 64.1% (645/1006) and 35.9% (391/1006) presented respectively positive and negative serology tests for anti-T. gondii antibodies. The mean age of those who tested positive was higher than those with negative serology tests (p = 0.0004). The frequencies of ABO blood group phenotypes were similar in those with and without anti-T. gondii antibodies (p = 0.35). In conclusion, the ABO blood group system is not associated with the presence or absence of anti-T. gondii antibodies.

Prematurity and Low Birth Weight did not Correlate with Anti-Toxoplasma gondii Maternal Serum Profiles – a Brazilian Report

“…The frequencies of the identified serological profiles in patients in our study are consistent with findings in the literature [ 47 , 48 ]. The prevalence of T .…”

“…The simultaneous presence of anti- T . gondii IgM and IgG classes is transient in most cases and therefore the percentage of pregnant women with this profile is smaller than the other mentioned above [ 14 , 18 , 31 , 47 , 49 , 50 ].…”

“…Dias et al [ 52 ], Rodrigues et al [ 47 ] and Ferenzi and et al [ 53 ] reported a higher mean age for positive pregnant women with IgG anti- T . gondii compared to those not exposed to the parasite.…”

“…The high rates of infection in the region of origin of pregnant women evaluated in this study can contribute to re-exposure to the parasite favoring the prevalence of anti- T . gondii IgG class antibodies in the population [ 2 , 31 , 47 , 57 – 60 ].…”

Toxoplasmose ocular com reação em cadeia da polimerase positiva em sangue periférico – relato de dois casos, estado de São Paulo, Brasil

“…A previous report shows that around 27% of patients treated at an ophthalmology outpatient clinic had clinical evidence of OT [15]. Contact with soil and pets was regarded as an important risk factor for T. gondii infection, which also affects about 65% of pregnant women in this region [16][17][18]. These data are consistent with reports from other Brazilian regions [5,[19][20][21].…”